Extracellular vesicles derived-microRNAs predicting enzalutamide-resistance in 3D spheroid prostate Cancer model

Enzalutamide (ENZ) has emerged as a major treatment advance in castration-resistant prostate cancer (CRPC) patients; however the development of resistance remains a key challenge. The extracellular vesicles (VEs)-derived miRNAs play crucial roles tumor microenvironment cell communication, thereby in...

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Veröffentlicht in:	International journal of biological macromolecules 2025-01, Vol.284 (Pt 1), p.137993, Article 137993
Hauptverfasser:	Tavares, Inês, Morais, Mariana, Dias, Francisca, Ferreira, Mariana, Martins, Gabriela, Fernandes, Rui, Bidarra, Sílvia Joana, Medeiros, Rui, Teixeira, Ana Luísa
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides - pharmacology Cell Line, Tumor Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Extracellular Vesicles - genetics Extracellular Vesicles - metabolism Extracellular vesicles derived-miRNAs Gene Expression Regulation, Neoplastic - drug effects Humans Male MicroRNAs - genetics Nitriles - pharmacology Phenylthiohydantoin - analogs & derivatives Phenylthiohydantoin - pharmacology Predictive biomarkers Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - pathology Resistance acquisition Spheroids, Cellular - drug effects
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