Peripheral fatty acids and outcome of assisted reproduction
•This study investigated fatty acid levels in whole blood in women undergoing in vitro fertilization, analyzing the ranges of fatty acid concentrations associated with four assisted reproductive technology outcomes.•Large prospective studies followed by well-designed supplementation trials are neede...
Gespeichert in:
| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2025-02, Vol.130, p.112616, Article 112616 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 112616 |
| container_title | Nutrition (Burbank, Los Angeles County, Calif.) |
| container_volume | 130 |
| creator | De Cosmi, Valentina Cipriani, Sonia Syren, Marie-Louise Turolo, Stefano Parazzini, Fabio Reschini, Marco Abodi, Martina Vegetti, Walter Chiaffarino, Francesca Bertoni, Camilla Somigliana, Edgardo Agostoni, Carlo |
| description | •This study investigated fatty acid levels in whole blood in women undergoing in vitro fertilization, analyzing the ranges of fatty acid concentrations associated with four assisted reproductive technology outcomes.•Large prospective studies followed by well-designed supplementation trials are needed to determine the ranges of fatty acid concentrations as well as the ideal fatty acid intake through diet or pharmacological interventions that may benefit women with subfertility.
The present study investigated the relationship between fatty acid levels in whole blood in women undergoing in vitro fertilization and four successive assisted reproductive technology (ART) outcomes.
A cross-sectional study was performed on data from a prospective cohort study conducted between 2014 and 2016.
Participants were 238 women undergoing in vitro fertilization and participating in a study on the role of lifestyle habits and diet in ART outcomes. Blood polyunsaturated fatty acids were measured by gas chromatography. Overall, higher blood levels of monounsaturated fatty acids and oleic acid and higher ω-6/ω-3 ratio and arachidonic/docosahexaenoic acid ratio were associated with more favorable ART outcomes. By contrast, higher concentrations of long chain polyunsaturated fatty acids tended to be negatively associated with the considered outcomes.
Further prospective studies are needed to determine the ranges of fatty acid concentrations that are optimal for women with subfertility. |
| doi_str_mv | 10.1016/j.nut.2024.112616 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3133414867</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S089990072400265X</els_id><sourcerecordid>3142574724</sourcerecordid><originalsourceid>FETCH-LOGICAL-c263t-458fecd2e46bbe2c8cc750dcfe426cf387c612e2c56d64ee894b804f216379af3</originalsourceid><addsrcrecordid>eNp9kE1rGzEQhkVJqR23PyCXsJBLL-vqa_VBTsWkScCQHtqzkKURlbFXrqQt-N9HxmkOOeQ0h3ned4YHoSuClwQT8W27HKe6pJjyJSFUEPEBzYmSrCeU8ws0x0rrXmMsZ-iylC3GmGihP6EZ04MmUrE5uv0JOR7-QLa7Lthaj5110ZfOjr5LU3VpD10KnS0llgq-y3DIyU-uxjR-Rh-D3RX48jIX6PePu1-rh379dP-4-r7uHRWs9nxQAZynwMVmA9Qp5-SAvQvAqXCBKekEoW0xCC84gNJ8ozAPlAgmtQ1sgb6ee9vpvxOUavaxONjt7AhpKoYRxjjhSsiG3rxBt2nKY_uuUZwOkkvKG0XOlMuplAzBHHLc23w0BJuTWbM1zaw5mTVnsy1z_dI8bfbgXxP_VTbg9gxAU_EvQjbFRRgd-JjBVeNTfKf-GSAniGY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3142574724</pqid></control><display><type>article</type><title>Peripheral fatty acids and outcome of assisted reproduction</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>De Cosmi, Valentina ; Cipriani, Sonia ; Syren, Marie-Louise ; Turolo, Stefano ; Parazzini, Fabio ; Reschini, Marco ; Abodi, Martina ; Vegetti, Walter ; Chiaffarino, Francesca ; Bertoni, Camilla ; Somigliana, Edgardo ; Agostoni, Carlo</creator><creatorcontrib>De Cosmi, Valentina ; Cipriani, Sonia ; Syren, Marie-Louise ; Turolo, Stefano ; Parazzini, Fabio ; Reschini, Marco ; Abodi, Martina ; Vegetti, Walter ; Chiaffarino, Francesca ; Bertoni, Camilla ; Somigliana, Edgardo ; Agostoni, Carlo</creatorcontrib><description>•This study investigated fatty acid levels in whole blood in women undergoing in vitro fertilization, analyzing the ranges of fatty acid concentrations associated with four assisted reproductive technology outcomes.•Large prospective studies followed by well-designed supplementation trials are needed to determine the ranges of fatty acid concentrations as well as the ideal fatty acid intake through diet or pharmacological interventions that may benefit women with subfertility.
The present study investigated the relationship between fatty acid levels in whole blood in women undergoing in vitro fertilization and four successive assisted reproductive technology (ART) outcomes.
A cross-sectional study was performed on data from a prospective cohort study conducted between 2014 and 2016.
Participants were 238 women undergoing in vitro fertilization and participating in a study on the role of lifestyle habits and diet in ART outcomes. Blood polyunsaturated fatty acids were measured by gas chromatography. Overall, higher blood levels of monounsaturated fatty acids and oleic acid and higher ω-6/ω-3 ratio and arachidonic/docosahexaenoic acid ratio were associated with more favorable ART outcomes. By contrast, higher concentrations of long chain polyunsaturated fatty acids tended to be negatively associated with the considered outcomes.
Further prospective studies are needed to determine the ranges of fatty acid concentrations that are optimal for women with subfertility.</description><identifier>ISSN: 0899-9007</identifier><identifier>ISSN: 1873-1244</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2024.112616</identifier><identifier>PMID: 39591783</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Assisted reproduction ; Blood ; Blood levels ; Body mass index ; Chromatography ; Clinical outcomes ; Clinical pregnancy ; Cohort analysis ; Cross-Sectional Studies ; Docosahexaenoic acid ; Embryo transfer ; Embryos ; Fatty acids ; Fatty Acids - blood ; Fatty Acids, Omega-6 - blood ; Fatty Acids, Unsaturated - blood ; Female ; Females ; Fertility ; Fertilization in Vitro - methods ; Gas chromatography ; Good-quality oocyte ; Hormone replacement therapy ; Humans ; In vitro fertilization ; In vitro methods and tests ; Infertility ; Live birth ; Menstruation ; Metabolism ; Multivariate analysis ; Obesity ; Oleic acid ; Ovaries ; Ovulation ; Polyunsaturated fatty acids ; Pregnancy ; Prospective Studies ; Reproductive Techniques, Assisted - statistics & numerical data ; Reproductive technologies ; Sperm ; Treatment Outcome ; Vitamin B</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2025-02, Vol.130, p.112616, Article 112616</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><rights>2024. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c263t-458fecd2e46bbe2c8cc750dcfe426cf387c612e2c56d64ee894b804f216379af3</cites><orcidid>0000-0002-0530-499X ; 0009-0002-5310-6274 ; 0000-0003-0857-8432 ; 0000-0002-9868-3043 ; 0000-0002-9178-0713 ; 0000-0001-6009-8108</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.nut.2024.112616$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39591783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Cosmi, Valentina</creatorcontrib><creatorcontrib>Cipriani, Sonia</creatorcontrib><creatorcontrib>Syren, Marie-Louise</creatorcontrib><creatorcontrib>Turolo, Stefano</creatorcontrib><creatorcontrib>Parazzini, Fabio</creatorcontrib><creatorcontrib>Reschini, Marco</creatorcontrib><creatorcontrib>Abodi, Martina</creatorcontrib><creatorcontrib>Vegetti, Walter</creatorcontrib><creatorcontrib>Chiaffarino, Francesca</creatorcontrib><creatorcontrib>Bertoni, Camilla</creatorcontrib><creatorcontrib>Somigliana, Edgardo</creatorcontrib><creatorcontrib>Agostoni, Carlo</creatorcontrib><title>Peripheral fatty acids and outcome of assisted reproduction</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>•This study investigated fatty acid levels in whole blood in women undergoing in vitro fertilization, analyzing the ranges of fatty acid concentrations associated with four assisted reproductive technology outcomes.•Large prospective studies followed by well-designed supplementation trials are needed to determine the ranges of fatty acid concentrations as well as the ideal fatty acid intake through diet or pharmacological interventions that may benefit women with subfertility.
The present study investigated the relationship between fatty acid levels in whole blood in women undergoing in vitro fertilization and four successive assisted reproductive technology (ART) outcomes.
A cross-sectional study was performed on data from a prospective cohort study conducted between 2014 and 2016.
Participants were 238 women undergoing in vitro fertilization and participating in a study on the role of lifestyle habits and diet in ART outcomes. Blood polyunsaturated fatty acids were measured by gas chromatography. Overall, higher blood levels of monounsaturated fatty acids and oleic acid and higher ω-6/ω-3 ratio and arachidonic/docosahexaenoic acid ratio were associated with more favorable ART outcomes. By contrast, higher concentrations of long chain polyunsaturated fatty acids tended to be negatively associated with the considered outcomes.
Further prospective studies are needed to determine the ranges of fatty acid concentrations that are optimal for women with subfertility.</description><subject>Adult</subject><subject>Assisted reproduction</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Body mass index</subject><subject>Chromatography</subject><subject>Clinical outcomes</subject><subject>Clinical pregnancy</subject><subject>Cohort analysis</subject><subject>Cross-Sectional Studies</subject><subject>Docosahexaenoic acid</subject><subject>Embryo transfer</subject><subject>Embryos</subject><subject>Fatty acids</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids, Omega-6 - blood</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>Female</subject><subject>Females</subject><subject>Fertility</subject><subject>Fertilization in Vitro - methods</subject><subject>Gas chromatography</subject><subject>Good-quality oocyte</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>In vitro methods and tests</subject><subject>Infertility</subject><subject>Live birth</subject><subject>Menstruation</subject><subject>Metabolism</subject><subject>Multivariate analysis</subject><subject>Obesity</subject><subject>Oleic acid</subject><subject>Ovaries</subject><subject>Ovulation</subject><subject>Polyunsaturated fatty acids</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Reproductive Techniques, Assisted - statistics & numerical data</subject><subject>Reproductive technologies</subject><subject>Sperm</subject><subject>Treatment Outcome</subject><subject>Vitamin B</subject><issn>0899-9007</issn><issn>1873-1244</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVJqR23PyCXsJBLL-vqa_VBTsWkScCQHtqzkKURlbFXrqQt-N9HxmkOOeQ0h3ned4YHoSuClwQT8W27HKe6pJjyJSFUEPEBzYmSrCeU8ws0x0rrXmMsZ-iylC3GmGihP6EZ04MmUrE5uv0JOR7-QLa7Lthaj5110ZfOjr5LU3VpD10KnS0llgq-y3DIyU-uxjR-Rh-D3RX48jIX6PePu1-rh379dP-4-r7uHRWs9nxQAZynwMVmA9Qp5-SAvQvAqXCBKekEoW0xCC84gNJ8ozAPlAgmtQ1sgb6ee9vpvxOUavaxONjt7AhpKoYRxjjhSsiG3rxBt2nKY_uuUZwOkkvKG0XOlMuplAzBHHLc23w0BJuTWbM1zaw5mTVnsy1z_dI8bfbgXxP_VTbg9gxAU_EvQjbFRRgd-JjBVeNTfKf-GSAniGY</recordid><startdate>202502</startdate><enddate>202502</enddate><creator>De Cosmi, Valentina</creator><creator>Cipriani, Sonia</creator><creator>Syren, Marie-Louise</creator><creator>Turolo, Stefano</creator><creator>Parazzini, Fabio</creator><creator>Reschini, Marco</creator><creator>Abodi, Martina</creator><creator>Vegetti, Walter</creator><creator>Chiaffarino, Francesca</creator><creator>Bertoni, Camilla</creator><creator>Somigliana, Edgardo</creator><creator>Agostoni, Carlo</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U7</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0530-499X</orcidid><orcidid>https://orcid.org/0009-0002-5310-6274</orcidid><orcidid>https://orcid.org/0000-0003-0857-8432</orcidid><orcidid>https://orcid.org/0000-0002-9868-3043</orcidid><orcidid>https://orcid.org/0000-0002-9178-0713</orcidid><orcidid>https://orcid.org/0000-0001-6009-8108</orcidid></search><sort><creationdate>202502</creationdate><title>Peripheral fatty acids and outcome of assisted reproduction</title><author>De Cosmi, Valentina ; Cipriani, Sonia ; Syren, Marie-Louise ; Turolo, Stefano ; Parazzini, Fabio ; Reschini, Marco ; Abodi, Martina ; Vegetti, Walter ; Chiaffarino, Francesca ; Bertoni, Camilla ; Somigliana, Edgardo ; Agostoni, Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c263t-458fecd2e46bbe2c8cc750dcfe426cf387c612e2c56d64ee894b804f216379af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Assisted reproduction</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Body mass index</topic><topic>Chromatography</topic><topic>Clinical outcomes</topic><topic>Clinical pregnancy</topic><topic>Cohort analysis</topic><topic>Cross-Sectional Studies</topic><topic>Docosahexaenoic acid</topic><topic>Embryo transfer</topic><topic>Embryos</topic><topic>Fatty acids</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids, Omega-6 - blood</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>Female</topic><topic>Females</topic><topic>Fertility</topic><topic>Fertilization in Vitro - methods</topic><topic>Gas chromatography</topic><topic>Good-quality oocyte</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>In vitro methods and tests</topic><topic>Infertility</topic><topic>Live birth</topic><topic>Menstruation</topic><topic>Metabolism</topic><topic>Multivariate analysis</topic><topic>Obesity</topic><topic>Oleic acid</topic><topic>Ovaries</topic><topic>Ovulation</topic><topic>Polyunsaturated fatty acids</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Reproductive Techniques, Assisted - statistics & numerical data</topic><topic>Reproductive technologies</topic><topic>Sperm</topic><topic>Treatment Outcome</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Cosmi, Valentina</creatorcontrib><creatorcontrib>Cipriani, Sonia</creatorcontrib><creatorcontrib>Syren, Marie-Louise</creatorcontrib><creatorcontrib>Turolo, Stefano</creatorcontrib><creatorcontrib>Parazzini, Fabio</creatorcontrib><creatorcontrib>Reschini, Marco</creatorcontrib><creatorcontrib>Abodi, Martina</creatorcontrib><creatorcontrib>Vegetti, Walter</creatorcontrib><creatorcontrib>Chiaffarino, Francesca</creatorcontrib><creatorcontrib>Bertoni, Camilla</creatorcontrib><creatorcontrib>Somigliana, Edgardo</creatorcontrib><creatorcontrib>Agostoni, Carlo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Cosmi, Valentina</au><au>Cipriani, Sonia</au><au>Syren, Marie-Louise</au><au>Turolo, Stefano</au><au>Parazzini, Fabio</au><au>Reschini, Marco</au><au>Abodi, Martina</au><au>Vegetti, Walter</au><au>Chiaffarino, Francesca</au><au>Bertoni, Camilla</au><au>Somigliana, Edgardo</au><au>Agostoni, Carlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral fatty acids and outcome of assisted reproduction</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2025-02</date><risdate>2025</risdate><volume>130</volume><spage>112616</spage><pages>112616-</pages><artnum>112616</artnum><issn>0899-9007</issn><issn>1873-1244</issn><eissn>1873-1244</eissn><abstract>•This study investigated fatty acid levels in whole blood in women undergoing in vitro fertilization, analyzing the ranges of fatty acid concentrations associated with four assisted reproductive technology outcomes.•Large prospective studies followed by well-designed supplementation trials are needed to determine the ranges of fatty acid concentrations as well as the ideal fatty acid intake through diet or pharmacological interventions that may benefit women with subfertility.
The present study investigated the relationship between fatty acid levels in whole blood in women undergoing in vitro fertilization and four successive assisted reproductive technology (ART) outcomes.
A cross-sectional study was performed on data from a prospective cohort study conducted between 2014 and 2016.
Participants were 238 women undergoing in vitro fertilization and participating in a study on the role of lifestyle habits and diet in ART outcomes. Blood polyunsaturated fatty acids were measured by gas chromatography. Overall, higher blood levels of monounsaturated fatty acids and oleic acid and higher ω-6/ω-3 ratio and arachidonic/docosahexaenoic acid ratio were associated with more favorable ART outcomes. By contrast, higher concentrations of long chain polyunsaturated fatty acids tended to be negatively associated with the considered outcomes.
Further prospective studies are needed to determine the ranges of fatty acid concentrations that are optimal for women with subfertility.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39591783</pmid><doi>10.1016/j.nut.2024.112616</doi><orcidid>https://orcid.org/0000-0002-0530-499X</orcidid><orcidid>https://orcid.org/0009-0002-5310-6274</orcidid><orcidid>https://orcid.org/0000-0003-0857-8432</orcidid><orcidid>https://orcid.org/0000-0002-9868-3043</orcidid><orcidid>https://orcid.org/0000-0002-9178-0713</orcidid><orcidid>https://orcid.org/0000-0001-6009-8108</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2025-02, Vol.130, p.112616, Article 112616 |
| issn | 0899-9007 1873-1244 1873-1244 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3133414867 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Assisted reproduction Blood Blood levels Body mass index Chromatography Clinical outcomes Clinical pregnancy Cohort analysis Cross-Sectional Studies Docosahexaenoic acid Embryo transfer Embryos Fatty acids Fatty Acids - blood Fatty Acids, Omega-6 - blood Fatty Acids, Unsaturated - blood Female Females Fertility Fertilization in Vitro - methods Gas chromatography Good-quality oocyte Hormone replacement therapy Humans In vitro fertilization In vitro methods and tests Infertility Live birth Menstruation Metabolism Multivariate analysis Obesity Oleic acid Ovaries Ovulation Polyunsaturated fatty acids Pregnancy Prospective Studies Reproductive Techniques, Assisted - statistics & numerical data Reproductive technologies Sperm Treatment Outcome Vitamin B |
| title | Peripheral fatty acids and outcome of assisted reproduction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T16%3A41%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Peripheral%20fatty%20acids%20and%20outcome%20of%20assisted%20reproduction&rft.jtitle=Nutrition%20(Burbank,%20Los%20Angeles%20County,%20Calif.)&rft.au=De%20Cosmi,%20Valentina&rft.date=2025-02&rft.volume=130&rft.spage=112616&rft.pages=112616-&rft.artnum=112616&rft.issn=0899-9007&rft.eissn=1873-1244&rft_id=info:doi/10.1016/j.nut.2024.112616&rft_dat=%3Cproquest_cross%3E3142574724%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3142574724&rft_id=info:pmid/39591783&rft_els_id=S089990072400265X&rfr_iscdi=true |