Cisplatin caused highly delayed cytotoxicity in the immortalized cells derived from S3 segment of mouse kidney proximal tubules

Anti-cancer drug cisplatin (CDDP) causes severe acute kidney injury (AKI). CDDP-induced AKI does not occur immediately after administration, but rather 6 to 10 days after administration. However, the mechanism underling the delayed renal injury by CDDP is not well understood. In a previous investiga...

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Veröffentlicht in:	Toxicology and applied pharmacology 2025-01, Vol.494, p.117171, Article 117171
Hauptverfasser:	Taguchi, Hiroki, Sumi, Daigo, Uemura, Ayumi, Matsumoto, Kanako, Fujishiro, Hitomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Acute Kidney Injury - chemically induced Acute Kidney Injury - pathology Animals Antineoplastic Agents - toxicity Cell cycle Cell Cycle - drug effects Cell Line Cell Line, Transformed Cell Survival - drug effects Cisplatin Cisplatin - toxicity Kidney injury Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - pathology Mice Proximal tubule Time Factors
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