Plant protein dominant enteral nutrition, containing soy and pea, is non-coagulating after gastric digestion in contrast to casein dominant enteral nutrition
[Display omitted] •A new plant-dominant protein blend was developed for enteral nutrition (EN)•The new protein blend is non-coagulating after in vitro gastric digestion.•The blend demonstrated this property as protein solution and while in EN matrices.•This property is independent of energy density,...
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| Veröffentlicht in: | Food research international 2024-12, Vol.197 (Pt 1), p.115162, Article 115162 |
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| creator | van Eck, Esmée B. Hofman, Zandrie van Eijnatten, Elise J.M. Knol, Jan Renes, Ingrid B. Abrahamse, Evan |
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•A new plant-dominant protein blend was developed for enteral nutrition (EN)•The new protein blend is non-coagulating after in vitro gastric digestion.•The blend demonstrated this property as protein solution and while in EN matrices.•This property is independent of energy density, protein content and dietary fibers.•EN with plant-dominant protein blend may support upper gastrointestinal tolerance.
Enteral Nutrition (EN) is used for the dietary management of patients requiring tube feed and who are at risk of disease related malnutrition. Previously, EN with a dairy-dominant p4 protein blend (DD-P4: 20% soy, 20% pea, 25% casein and 35% whey) was shown to not coagulate in the stomach, increase gastric emptying rate and reduce gastric residual volume compared to EN with casein-dominant protein blends (CD; 80% casein and 20% whey), which is relevant for upper gastrointestinal tolerance. In line with the EAT-Lancet report, a new plant-dominant protein blend (PD-P4: 46% soy, 32% pea, 16% casein and 6% whey) was developed.
Coagulating properties of PD-P4 are compared to DD-P4 and dairy proteins in protein solutions as well as in EN matrices, using a semi-dynamic in vitro gastric model simulating adult conditions, followed by solid particle (> 0.25 mm) separation using analytical sieving. Sieve retentates and filtrates were assayed for weight, dry matter, and protein content where possible.
Whey protein, PD-P4 and DD-P4 protein solutions as well as PD-P4 and DD-P4 EN variants had minimal total particle weights. In contrast, casein protein solution coagulation amounted to ∼ 21 % of its initial wet weight, containing ∼ 51 % of its initial protein content, and CD EN coagulation amounted to 21 %- 45 % of the initial wet weight, containing 59–65 % of the initial protein content.
EN with the new PD-P4 blend can be considered non-coagulating after in-vitro gastric digestion, similar to the DD-P4 blend. This was independent of energy density, protein content, and the presence of dietary fiber. EN with a non-coagulating plant-dominant protein blend might support upper gastrointestinal tolerance and promote the worldwide protein transition. |
| doi_str_mv | 10.1016/j.foodres.2024.115162 |
| format | Article |
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•A new plant-dominant protein blend was developed for enteral nutrition (EN)•The new protein blend is non-coagulating after in vitro gastric digestion.•The blend demonstrated this property as protein solution and while in EN matrices.•This property is independent of energy density, protein content and dietary fibers.•EN with plant-dominant protein blend may support upper gastrointestinal tolerance.
Enteral Nutrition (EN) is used for the dietary management of patients requiring tube feed and who are at risk of disease related malnutrition. Previously, EN with a dairy-dominant p4 protein blend (DD-P4: 20% soy, 20% pea, 25% casein and 35% whey) was shown to not coagulate in the stomach, increase gastric emptying rate and reduce gastric residual volume compared to EN with casein-dominant protein blends (CD; 80% casein and 20% whey), which is relevant for upper gastrointestinal tolerance. In line with the EAT-Lancet report, a new plant-dominant protein blend (PD-P4: 46% soy, 32% pea, 16% casein and 6% whey) was developed.
Coagulating properties of PD-P4 are compared to DD-P4 and dairy proteins in protein solutions as well as in EN matrices, using a semi-dynamic in vitro gastric model simulating adult conditions, followed by solid particle (> 0.25 mm) separation using analytical sieving. Sieve retentates and filtrates were assayed for weight, dry matter, and protein content where possible.
Whey protein, PD-P4 and DD-P4 protein solutions as well as PD-P4 and DD-P4 EN variants had minimal total particle weights. In contrast, casein protein solution coagulation amounted to ∼ 21 % of its initial wet weight, containing ∼ 51 % of its initial protein content, and CD EN coagulation amounted to 21 %- 45 % of the initial wet weight, containing 59–65 % of the initial protein content.
EN with the new PD-P4 blend can be considered non-coagulating after in-vitro gastric digestion, similar to the DD-P4 blend. This was independent of energy density, protein content, and the presence of dietary fiber. EN with a non-coagulating plant-dominant protein blend might support upper gastrointestinal tolerance and promote the worldwide protein transition.</description><identifier>ISSN: 0963-9969</identifier><identifier>ISSN: 1873-7145</identifier><identifier>EISSN: 1873-7145</identifier><identifier>DOI: 10.1016/j.foodres.2024.115162</identifier><identifier>PMID: 39593374</identifier><language>eng</language><publisher>Canada: Elsevier Ltd</publisher><subject>Caseins - metabolism ; Digestion ; Enteral Nutrition ; Gastric coagulation ; Gastric Emptying ; Gastrointestinal tolerance ; Glycine max - chemistry ; Humans ; In vitro digestion ; Pea Proteins - chemistry ; Pisum sativum - chemistry ; Plant Proteins ; Protein clotting ; Protein coagulation ; Protein transition ; Soybean Proteins - chemistry ; Soybean Proteins - metabolism ; Stomach ; Tube feed ; Whey Proteins - metabolism</subject><ispartof>Food research international, 2024-12, Vol.197 (Pt 1), p.115162, Article 115162</ispartof><rights>2024 The Author(s)</rights><rights>Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c243t-89ab643ee8051daf55ba7bdc55e99748f909efa66b990eee687e91bc38ce5b4d3</cites><orcidid>0000-0002-3263-824X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodres.2024.115162$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39593374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Eck, Esmée B.</creatorcontrib><creatorcontrib>Hofman, Zandrie</creatorcontrib><creatorcontrib>van Eijnatten, Elise J.M.</creatorcontrib><creatorcontrib>Knol, Jan</creatorcontrib><creatorcontrib>Renes, Ingrid B.</creatorcontrib><creatorcontrib>Abrahamse, Evan</creatorcontrib><title>Plant protein dominant enteral nutrition, containing soy and pea, is non-coagulating after gastric digestion in contrast to casein dominant enteral nutrition</title><title>Food research international</title><addtitle>Food Res Int</addtitle><description>[Display omitted]
•A new plant-dominant protein blend was developed for enteral nutrition (EN)•The new protein blend is non-coagulating after in vitro gastric digestion.•The blend demonstrated this property as protein solution and while in EN matrices.•This property is independent of energy density, protein content and dietary fibers.•EN with plant-dominant protein blend may support upper gastrointestinal tolerance.
Enteral Nutrition (EN) is used for the dietary management of patients requiring tube feed and who are at risk of disease related malnutrition. Previously, EN with a dairy-dominant p4 protein blend (DD-P4: 20% soy, 20% pea, 25% casein and 35% whey) was shown to not coagulate in the stomach, increase gastric emptying rate and reduce gastric residual volume compared to EN with casein-dominant protein blends (CD; 80% casein and 20% whey), which is relevant for upper gastrointestinal tolerance. In line with the EAT-Lancet report, a new plant-dominant protein blend (PD-P4: 46% soy, 32% pea, 16% casein and 6% whey) was developed.
Coagulating properties of PD-P4 are compared to DD-P4 and dairy proteins in protein solutions as well as in EN matrices, using a semi-dynamic in vitro gastric model simulating adult conditions, followed by solid particle (> 0.25 mm) separation using analytical sieving. Sieve retentates and filtrates were assayed for weight, dry matter, and protein content where possible.
Whey protein, PD-P4 and DD-P4 protein solutions as well as PD-P4 and DD-P4 EN variants had minimal total particle weights. In contrast, casein protein solution coagulation amounted to ∼ 21 % of its initial wet weight, containing ∼ 51 % of its initial protein content, and CD EN coagulation amounted to 21 %- 45 % of the initial wet weight, containing 59–65 % of the initial protein content.
EN with the new PD-P4 blend can be considered non-coagulating after in-vitro gastric digestion, similar to the DD-P4 blend. This was independent of energy density, protein content, and the presence of dietary fiber. EN with a non-coagulating plant-dominant protein blend might support upper gastrointestinal tolerance and promote the worldwide protein transition.</description><subject>Caseins - metabolism</subject><subject>Digestion</subject><subject>Enteral Nutrition</subject><subject>Gastric coagulation</subject><subject>Gastric Emptying</subject><subject>Gastrointestinal tolerance</subject><subject>Glycine max - chemistry</subject><subject>Humans</subject><subject>In vitro digestion</subject><subject>Pea Proteins - chemistry</subject><subject>Pisum sativum - chemistry</subject><subject>Plant Proteins</subject><subject>Protein clotting</subject><subject>Protein coagulation</subject><subject>Protein transition</subject><subject>Soybean Proteins - chemistry</subject><subject>Soybean Proteins - metabolism</subject><subject>Stomach</subject><subject>Tube feed</subject><subject>Whey Proteins - metabolism</subject><issn>0963-9969</issn><issn>1873-7145</issn><issn>1873-7145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctuGyEUhlHVqHHSPkIrll1kHDCXGVZVZSVNJUvJIlkjBs5YWGNwgYmUh8m7hpHdLNsVEue_wPkQ-krJkhIqr3fLIUaXIC9XZMWXlAoqVx_QgnYta1rKxUe0IEqyRimpztFFzjtCiBSt-oTOmRKKsZYv0OvDaELBhxQL-IBd3PswX0AokMyIw1SSLz6GK2xjKMYHH7Y4xxdsgsMHMFfYZxxiaGw022k0ZZ6bobrx1uRqttj5LeQ5A9eGOSXVAS4RW5P_XfoZnQ1mzPDldF6ip9ubx_Vds7n_9Xv9c9PYFWel6ZTpJWcAHRHUmUGI3rS9s0KAUi3vBkUUDEbKXikCALJrQdHess6C6Lljl-j7Mbfu4c9UH6v3PlsY624gTlkzyhinnHFVpeIotSnmnGDQh-T3Jr1oSvRMRu_0iYyeyegjmer7dqqY-j24d9dfFFXw4yiA-tFnD0ln6yFYcD6BLdpF_5-KN9f3pxM</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>van Eck, Esmée B.</creator><creator>Hofman, Zandrie</creator><creator>van Eijnatten, Elise J.M.</creator><creator>Knol, Jan</creator><creator>Renes, Ingrid B.</creator><creator>Abrahamse, Evan</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3263-824X</orcidid></search><sort><creationdate>202412</creationdate><title>Plant protein dominant enteral nutrition, containing soy and pea, is non-coagulating after gastric digestion in contrast to casein dominant enteral nutrition</title><author>van Eck, Esmée B. ; Hofman, Zandrie ; van Eijnatten, Elise J.M. ; Knol, Jan ; Renes, Ingrid B. ; Abrahamse, Evan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c243t-89ab643ee8051daf55ba7bdc55e99748f909efa66b990eee687e91bc38ce5b4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Caseins - metabolism</topic><topic>Digestion</topic><topic>Enteral Nutrition</topic><topic>Gastric coagulation</topic><topic>Gastric Emptying</topic><topic>Gastrointestinal tolerance</topic><topic>Glycine max - chemistry</topic><topic>Humans</topic><topic>In vitro digestion</topic><topic>Pea Proteins - chemistry</topic><topic>Pisum sativum - chemistry</topic><topic>Plant Proteins</topic><topic>Protein clotting</topic><topic>Protein coagulation</topic><topic>Protein transition</topic><topic>Soybean Proteins - chemistry</topic><topic>Soybean Proteins - metabolism</topic><topic>Stomach</topic><topic>Tube feed</topic><topic>Whey Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Eck, Esmée B.</creatorcontrib><creatorcontrib>Hofman, Zandrie</creatorcontrib><creatorcontrib>van Eijnatten, Elise J.M.</creatorcontrib><creatorcontrib>Knol, Jan</creatorcontrib><creatorcontrib>Renes, Ingrid B.</creatorcontrib><creatorcontrib>Abrahamse, Evan</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Eck, Esmée B.</au><au>Hofman, Zandrie</au><au>van Eijnatten, Elise J.M.</au><au>Knol, Jan</au><au>Renes, Ingrid B.</au><au>Abrahamse, Evan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plant protein dominant enteral nutrition, containing soy and pea, is non-coagulating after gastric digestion in contrast to casein dominant enteral nutrition</atitle><jtitle>Food research international</jtitle><addtitle>Food Res Int</addtitle><date>2024-12</date><risdate>2024</risdate><volume>197</volume><issue>Pt 1</issue><spage>115162</spage><pages>115162-</pages><artnum>115162</artnum><issn>0963-9969</issn><issn>1873-7145</issn><eissn>1873-7145</eissn><abstract>[Display omitted]
•A new plant-dominant protein blend was developed for enteral nutrition (EN)•The new protein blend is non-coagulating after in vitro gastric digestion.•The blend demonstrated this property as protein solution and while in EN matrices.•This property is independent of energy density, protein content and dietary fibers.•EN with plant-dominant protein blend may support upper gastrointestinal tolerance.
Enteral Nutrition (EN) is used for the dietary management of patients requiring tube feed and who are at risk of disease related malnutrition. Previously, EN with a dairy-dominant p4 protein blend (DD-P4: 20% soy, 20% pea, 25% casein and 35% whey) was shown to not coagulate in the stomach, increase gastric emptying rate and reduce gastric residual volume compared to EN with casein-dominant protein blends (CD; 80% casein and 20% whey), which is relevant for upper gastrointestinal tolerance. In line with the EAT-Lancet report, a new plant-dominant protein blend (PD-P4: 46% soy, 32% pea, 16% casein and 6% whey) was developed.
Coagulating properties of PD-P4 are compared to DD-P4 and dairy proteins in protein solutions as well as in EN matrices, using a semi-dynamic in vitro gastric model simulating adult conditions, followed by solid particle (> 0.25 mm) separation using analytical sieving. Sieve retentates and filtrates were assayed for weight, dry matter, and protein content where possible.
Whey protein, PD-P4 and DD-P4 protein solutions as well as PD-P4 and DD-P4 EN variants had minimal total particle weights. In contrast, casein protein solution coagulation amounted to ∼ 21 % of its initial wet weight, containing ∼ 51 % of its initial protein content, and CD EN coagulation amounted to 21 %- 45 % of the initial wet weight, containing 59–65 % of the initial protein content.
EN with the new PD-P4 blend can be considered non-coagulating after in-vitro gastric digestion, similar to the DD-P4 blend. This was independent of energy density, protein content, and the presence of dietary fiber. EN with a non-coagulating plant-dominant protein blend might support upper gastrointestinal tolerance and promote the worldwide protein transition.</abstract><cop>Canada</cop><pub>Elsevier Ltd</pub><pmid>39593374</pmid><doi>10.1016/j.foodres.2024.115162</doi><orcidid>https://orcid.org/0000-0002-3263-824X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Caseins - metabolism Digestion Enteral Nutrition Gastric coagulation Gastric Emptying Gastrointestinal tolerance Glycine max - chemistry Humans In vitro digestion Pea Proteins - chemistry Pisum sativum - chemistry Plant Proteins Protein clotting Protein coagulation Protein transition Soybean Proteins - chemistry Soybean Proteins - metabolism Stomach Tube feed Whey Proteins - metabolism |
| title | Plant protein dominant enteral nutrition, containing soy and pea, is non-coagulating after gastric digestion in contrast to casein dominant enteral nutrition |
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