Establishment of a workflow for high-throughput identification of anti-inflammatory peptides from sea cucumbers

[Display omitted] •Sea cucumber major yolk proteins are predicted as precursor proteins for peptides.•A portfolio of 170 peptides is identified from major yolk protein hydrolysates.•Twelve potential anti-inflammatory peptides are identified through virtual screening.•Peptides effectively inhibit NO...

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Veröffentlicht in:	Food research international 2024-12, Vol.197 (Pt 1), p.115171, Article 115171
Hauptverfasser:	Jiang, Bingxue, Liu, Jinqiu, Zhu, Zihao, Fu, Linlan, Chang, Yaoguang, Wang, Yanchao, Xue, Changhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-inflammatory peptides Antioxidants - analysis Antioxidants - pharmacology Cyclooxygenase 2 - metabolism Cytokines - metabolism High-Throughput Screening Assays - methods Major yolk protein Mice Molecular docking Molecular Docking Simulation Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Peptides - chemistry RAW 264.7 Cells Sea cucumber Sea Cucumbers - chemistry Workflow
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