Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome

The protozoan parasite Trichomonas vaginalis (Tv) causes trichomoniasis, the most common non‐viral sexually transmitted infection in the world. Although Tv has been linked to significant health complications, only two closely related 5‐nitroimidazole drugs are approved for its treatment. The emergen...

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Veröffentlicht in:	Protein science 2024-12, Vol.33 (12), p.e5225-n/a
Hauptverfasser:	Fajtova, Pavla, Hurysz, Brianna M., Miyamoto, Yukiko, Serafim, Mateus Sá M., Jiang, Zhenze, Vazquez, Julia M., Trujillo, Diego F., Liu, Lawrence J., Somani, Urvashi, Almaliti, Jehad, Myers, Samuel A., Caffrey, Conor R., Gerwick, William H., McMinn, Dustin L., Kirk, Christopher J., Boura, Evzen, Eckmann, Lars, O'Donoghue, Anthony J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain Catalytic subunits Drug development drug discovery Drug resistance drug screening Drugs Enzymes Eukaryotes Inhibitors Mass spectrometry Mass spectroscopy Nitroimidazole parasite Parasites Peptides protease inhibitor proteasome Proteasome Endopeptidase Complex - chemistry Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors - chemistry Proteasome Inhibitors - pharmacology Proteasomes Protozoan Proteins - antagonists & inhibitors Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism Public health Sexually transmitted diseases STD Substrate inhibition Substrate preferences Substrate Specificity Substrates Therapeutic targets trichomonas Trichomonas vaginalis Trichomonas vaginalis - enzymology Trichomoniasis
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