Ventral Root Boundary Cap Cells of Rat Spinal Cord Contain Connexin-43
Boundary cap cells are a population of multipotent stem cells that have great potential for the use in the treatment of damaged nervous system. We studied the patterns of distribution of the gap junction protein connexin-43 (Cx43) in boundary cap cells of the ventral root of the spinal cord of rat e...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2024-11, Vol.178 (1), p.157-162 |
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| creator | Kolos, E. A. Korzhevskii, D. E. |
| description | Boundary cap cells are a population of multipotent stem cells that have great potential for the use in the treatment of damaged nervous system. We studied the patterns of distribution of the gap junction protein connexin-43 (Cx43) in boundary cap cells of the ventral root of the spinal cord of rat embryos (E12-E20;
n
=40). It was found that Cx43 is expressed in ventral boundary cap cells at all stages of its existence during embryogenesis. At the early stages of prenatal development, the cytoplasmic distribution of Cx43 in the boundary cap cells predominates; at the later stages, Cx43-immunopositive punctate structures are identified. These puncta represent gap junction plaques between the cells. It can be assumed that during the early embryogenesis, Cx43 regulates the main histogenetic processes in boundary cap cells and only in the later stages of prenatal development, Cx43-mediated communications are formed between boundary cap cells. |
| doi_str_mv | 10.1007/s10517-024-06299-2 |
| format | Article |
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=40). It was found that Cx43 is expressed in ventral boundary cap cells at all stages of its existence during embryogenesis. At the early stages of prenatal development, the cytoplasmic distribution of Cx43 in the boundary cap cells predominates; at the later stages, Cx43-immunopositive punctate structures are identified. These puncta represent gap junction plaques between the cells. It can be assumed that during the early embryogenesis, Cx43 regulates the main histogenetic processes in boundary cap cells and only in the later stages of prenatal development, Cx43-mediated communications are formed between boundary cap cells.</description><identifier>ISSN: 0007-4888</identifier><identifier>ISSN: 1573-8221</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-024-06299-2</identifier><identifier>PMID: 39589621</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Antibodies ; Biology ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Connexin 43 ; Connexin 43 - genetics ; Connexin 43 - metabolism ; Developmental stages ; Embryogenesis ; Embryonic Development ; Embryos ; Female ; Gap Junctions - metabolism ; Internal Medicine ; Laboratory Medicine ; Medicine ; Multipotent Stem Cells - cytology ; Multipotent Stem Cells - metabolism ; Nervous system ; Pathology ; Population studies ; Pregnancy ; Prenatal development ; Proteins ; Rats ; Rats, Wistar ; Spinal cord ; Spinal Cord - cytology ; Spinal Cord - embryology ; Spinal Cord - metabolism ; Spinal Nerve Roots - cytology ; Spinal Nerve Roots - metabolism ; Stem cells ; Ventral roots</subject><ispartof>Bulletin of experimental biology and medicine, 2024-11, Vol.178 (1), p.157-162</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>Copyright Springer Nature B.V. Nov 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-4fd5685113fb642bdeb74e94ab0a26509ad6c25271160a19c1560604d39b3d4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-024-06299-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-024-06299-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39589621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolos, E. A.</creatorcontrib><creatorcontrib>Korzhevskii, D. E.</creatorcontrib><title>Ventral Root Boundary Cap Cells of Rat Spinal Cord Contain Connexin-43</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Boundary cap cells are a population of multipotent stem cells that have great potential for the use in the treatment of damaged nervous system. We studied the patterns of distribution of the gap junction protein connexin-43 (Cx43) in boundary cap cells of the ventral root of the spinal cord of rat embryos (E12-E20;
n
=40). It was found that Cx43 is expressed in ventral boundary cap cells at all stages of its existence during embryogenesis. At the early stages of prenatal development, the cytoplasmic distribution of Cx43 in the boundary cap cells predominates; at the later stages, Cx43-immunopositive punctate structures are identified. These puncta represent gap junction plaques between the cells. It can be assumed that during the early embryogenesis, Cx43 regulates the main histogenetic processes in boundary cap cells and only in the later stages of prenatal development, Cx43-mediated communications are formed between boundary cap cells.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Connexin 43</subject><subject>Connexin 43 - genetics</subject><subject>Connexin 43 - metabolism</subject><subject>Developmental stages</subject><subject>Embryogenesis</subject><subject>Embryonic Development</subject><subject>Embryos</subject><subject>Female</subject><subject>Gap Junctions - metabolism</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Multipotent Stem Cells - cytology</subject><subject>Multipotent Stem Cells - metabolism</subject><subject>Nervous system</subject><subject>Pathology</subject><subject>Population studies</subject><subject>Pregnancy</subject><subject>Prenatal development</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spinal cord</subject><subject>Spinal Cord - cytology</subject><subject>Spinal Cord - embryology</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Nerve Roots - cytology</subject><subject>Spinal Nerve Roots - metabolism</subject><subject>Stem cells</subject><subject>Ventral roots</subject><issn>0007-4888</issn><issn>1573-8221</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlKBDEQhoMoOi4v4EEavHiJprJ1ctTGUWFAcLuG9HRaWmaSMekGfXsziwoevKQI-eqv1IfQMZBzIKS8SEAElJhQjomkWmO6hUYgSoYVpbCNRiRTmCul9tB-Sm_LK5Gwi_aYFkpLCiM0fnG-j3ZWPITQF1dh8I2Nn0VlF0XlZrNUhLZ4sH3xuOh8pqoQm3z43nZ-Wb376Dzm7BDttHaW3NGmHqDn8fVTdYsn9zd31eUET6mQPeZtI6QSAKytJad14-qSO81tTSyVgmjbyEzSEkASC3oKQhJJeMN0zRru2AE6W-cuYngfXOrNvEvT_FHrXRiSYcCo4lIBzejpH_QtDDEvsaKUVlpQkim6pqYxpBRdaxaxm2cFBohZWjZryyZbNivLZhl9soke6rlrflq-tWaArYGUn_yri7-z_4n9Ar10hDE</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Kolos, E. A.</creator><creator>Korzhevskii, D. E.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20241101</creationdate><title>Ventral Root Boundary Cap Cells of Rat Spinal Cord Contain Connexin-43</title><author>Kolos, E. A. ; Korzhevskii, D. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-4fd5685113fb642bdeb74e94ab0a26509ad6c25271160a19c1560604d39b3d4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Biology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Connexin 43</topic><topic>Connexin 43 - genetics</topic><topic>Connexin 43 - metabolism</topic><topic>Developmental stages</topic><topic>Embryogenesis</topic><topic>Embryonic Development</topic><topic>Embryos</topic><topic>Female</topic><topic>Gap Junctions - metabolism</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Medicine</topic><topic>Multipotent Stem Cells - cytology</topic><topic>Multipotent Stem Cells - metabolism</topic><topic>Nervous system</topic><topic>Pathology</topic><topic>Population studies</topic><topic>Pregnancy</topic><topic>Prenatal development</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spinal cord</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - embryology</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal Nerve Roots - cytology</topic><topic>Spinal Nerve Roots - metabolism</topic><topic>Stem cells</topic><topic>Ventral roots</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolos, E. A.</creatorcontrib><creatorcontrib>Korzhevskii, D. E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolos, E. A.</au><au>Korzhevskii, D. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ventral Root Boundary Cap Cells of Rat Spinal Cord Contain Connexin-43</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>178</volume><issue>1</issue><spage>157</spage><epage>162</epage><pages>157-162</pages><issn>0007-4888</issn><issn>1573-8221</issn><eissn>1573-8221</eissn><abstract>Boundary cap cells are a population of multipotent stem cells that have great potential for the use in the treatment of damaged nervous system. We studied the patterns of distribution of the gap junction protein connexin-43 (Cx43) in boundary cap cells of the ventral root of the spinal cord of rat embryos (E12-E20;
n
=40). It was found that Cx43 is expressed in ventral boundary cap cells at all stages of its existence during embryogenesis. At the early stages of prenatal development, the cytoplasmic distribution of Cx43 in the boundary cap cells predominates; at the later stages, Cx43-immunopositive punctate structures are identified. These puncta represent gap junction plaques between the cells. It can be assumed that during the early embryogenesis, Cx43 regulates the main histogenetic processes in boundary cap cells and only in the later stages of prenatal development, Cx43-mediated communications are formed between boundary cap cells.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39589621</pmid><doi>10.1007/s10517-024-06299-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Antibodies Biology Biomedical and Life Sciences Biomedicine Cell Biology Connexin 43 Connexin 43 - genetics Connexin 43 - metabolism Developmental stages Embryogenesis Embryonic Development Embryos Female Gap Junctions - metabolism Internal Medicine Laboratory Medicine Medicine Multipotent Stem Cells - cytology Multipotent Stem Cells - metabolism Nervous system Pathology Population studies Pregnancy Prenatal development Proteins Rats Rats, Wistar Spinal cord Spinal Cord - cytology Spinal Cord - embryology Spinal Cord - metabolism Spinal Nerve Roots - cytology Spinal Nerve Roots - metabolism Stem cells Ventral roots |
| title | Ventral Root Boundary Cap Cells of Rat Spinal Cord Contain Connexin-43 |
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