TFA-promoted (hetero)arylation/hydroxylation of quinoxaline-2-one derivatives with electron-rich aromatic compounds

TFA-promoted (hetero)arylation/hydroxylation of quinoxaline-2-one derivatives with electron-rich aromatic compounds

A metal- and solvent-free, one-pot and TFA-promoted method for the construction of hetero/aryl-substituted quinoxalin-2-ones, pyrazin-2(1 )-ones, and pyrimidin-4(3 )-ones is reported. This method involves the reaction of chloro-derivatives of nitrogen heterocycles with electron-rich arenes/heteroare...

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Veröffentlicht in:Organic & biomolecular chemistry 2024-11
Hauptverfasser: Jatoth, Ramanna, Gugulothu, Kishan, Ravi, Nidhi, Gayathri, Ranamalla, Chandrakumar, Shravani Parehosahalli, Shiva Kumar, K
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container_title Organic & biomolecular chemistry
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creator Jatoth, Ramanna
Gugulothu, Kishan
Ravi, Nidhi
Gayathri, Ranamalla
Chandrakumar, Shravani Parehosahalli
Shiva Kumar, K
description A metal- and solvent-free, one-pot and TFA-promoted method for the construction of hetero/aryl-substituted quinoxalin-2-ones, pyrazin-2(1 )-ones, and pyrimidin-4(3 )-ones is reported. This method involves the reaction of chloro-derivatives of nitrogen heterocycles with electron-rich arenes/heteroarenes, followed by hydroxylation. This protocol is easy to use, providing access to (hetero)aryl-substituted -heterocycles in good yields.
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source Royal Society Of Chemistry Journals; Alma/SFX Local Collection
title TFA-promoted (hetero)arylation/hydroxylation of quinoxaline-2-one derivatives with electron-rich aromatic compounds
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