BBSome-deficient cells activate intraciliary CDC42 to trigger actin-dependent ciliary ectocytosis

Bardet-Biedl syndrome (BBS) is a pleiotropic ciliopathy caused by dysfunction of the BBSome, a cargo adaptor essential for export of transmembrane receptors from cilia. Although actin-dependent ectocytosis has been proposed to compensate defective cargo retrieval, its molecular basis remains unclear...

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Veröffentlicht in:	EMBO reports 2025-01, Vol.26 (1), p.36-60
Hauptverfasser:	Prasai, Avishek, Ivashchenko, Olha, Maskova, Kristyna, Bykova, Sofiia, Schmidt Cernohorska, Marketa, Stepanek, Ondrej, Huranova, Martina
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Bardet-Biedl Syndrome - genetics Bardet-Biedl Syndrome - metabolism Bardet-Biedl Syndrome - pathology Biomedical and Life Sciences cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cilia - metabolism EMBO05 EMBO20 EMBO37 Hedgehog Proteins - metabolism Humans Life Sciences Mice Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction
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