Utilization and associated factors of TPMT testing among Australian adults receiving thiopurines: A national retrospective data‐linkage study

Introduction Thiopurine drugs are metabolized by thiopurine methyltransferase (TPMT) and low TPMT activity can result in severe adverse drug reactions. Therefore, TPMT testing is recommended for individuals receiving thiopurines to reduce the risk of toxicity. Objectives The objectives of this study...

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Veröffentlicht in:	Pharmacotherapy 2025-01, Vol.45 (1), p.12-19
Hauptverfasser:	Yiu, Chin Hang, Ianni, Bella D., Fujita, Kenji, Tan, Edwin C. K., Hilmer, Sarah N., Lu, Christine Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Australia Cohort Studies Female Humans Male Methyltransferases - genetics Middle Aged pharmacogenetics pharmacogenomics precision medicine Primary care Retrospective Studies Thiopurine S-methyltransferase Toxicity Young Adult
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