Biocompatible DNA hydrogel composed of minimized Takumi-shaped DNA nanostructure exhibits sustained retention after in vivo administration

Our previous studies showed that DNA hydrogels containing unmethylated CpG motifs effectively induced antigen-specific immune responses when combined with the appropriate antigens. A potential drawback of existing DNA hydrogels for further applications is the need for many oligodeoxynucleotide (ODN)...

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Veröffentlicht in:	Journal of controlled release 2025-01, Vol.377, p.704-715
Hauptverfasser:	Jin, Jian, Kusamori, Kosuke, Tanifuji, Takumi, Yamagata, Yoshifumi, Itakura, Shoko, Nishikawa, Makiya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - chemistry Delayed-Action Preparations - chemistry DNA DNA - administration & dosage DNA hydrogel electrophoresis Female hydrogels Hydrogels - chemistry Mice nanomaterials Nanostructures - administration & dosage Nanostructures - chemistry Off-target effect oligodeoxyribonucleotides Oligodeoxyribonucleotides - administration & dosage Oligodeoxyribonucleotides - chemistry risk Self-assembly Structure optimization subcutaneous injection Sustained retention ability temperature viscoelasticity
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