Volumetric MRI correlates of persistent auditory verbal hallucinations and olfactory identification impairment in chronic schizophrenia: A cross-sectional study
Olfactory impairments are often observed in schizophrenia (SCZ) patients experiencing persistent auditory verbal hallucinations (pAVHs), yet it remains unclear whether these symptoms share a common neural mechanism with specific brain regions' gray matter volume (GMV) abnormalities. This study...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2025-01, Vol.136, p.111204, Article 111204 |
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| creator | Wang, Qianjin Li, Zongchang Li, Jinguang He, Ying Zhou, Jun Li, Chunwang Chen, Xiaogang Tang, Jinsong Ren, Honghong |
| description | Olfactory impairments are often observed in schizophrenia (SCZ) patients experiencing persistent auditory verbal hallucinations (pAVHs), yet it remains unclear whether these symptoms share a common neural mechanism with specific brain regions' gray matter volume (GMV) abnormalities. This study aimed to preliminarily elucidate olfactory impairment differences between SCZ patients with and without pAVHs and their correlation with GMV abnormalities in relevant brain regions.
A total of 75 SCZ patients with pAVHs (pAVH group), 56 SCZ patients without AVHs (non-AVH group), and 83 healthy controls (HC group) were examined. Voxel-based morphometry is useful for comparing and analyzing the differences in GMV among three groups. The Odor Stick Identification Test for Japanese (OSIT-J) was harnessed to gauge olfactory abilities.
Olfactory impairments are notably significant across entire SCZ patients compared to HC, with no significant differences in olfactory performance among SCZ subgroups. Notably, the pAVH group demonstrated a significant GMV diminution in the frontal-temporal cortex, starkly contrasting with the non-pAVH and HC groups. Intriguingly, stepwise regression analysis confirmed a strong positive relation between OSIT-J scores and a GMV reduction in the right medial orbitofrontal cortex (mOFC), although this correlation was only observed in the overall SCZ patient group (P |
| doi_str_mv | 10.1016/j.pnpbp.2024.111204 |
| format | Article |
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A total of 75 SCZ patients with pAVHs (pAVH group), 56 SCZ patients without AVHs (non-AVH group), and 83 healthy controls (HC group) were examined. Voxel-based morphometry is useful for comparing and analyzing the differences in GMV among three groups. The Odor Stick Identification Test for Japanese (OSIT-J) was harnessed to gauge olfactory abilities.
Olfactory impairments are notably significant across entire SCZ patients compared to HC, with no significant differences in olfactory performance among SCZ subgroups. Notably, the pAVH group demonstrated a significant GMV diminution in the frontal-temporal cortex, starkly contrasting with the non-pAVH and HC groups. Intriguingly, stepwise regression analysis confirmed a strong positive relation between OSIT-J scores and a GMV reduction in the right medial orbitofrontal cortex (mOFC), although this correlation was only observed in the overall SCZ patient group (P < 0.0036, Bonferroni correction).
The GMV perturbations within the mOFC, distinctive to SCZ, may underpin the neuroimaging substrates linked to heightened vulnerability to olfactory impairments in this population. This exploration underscores the imperative of delving into the neural underpinnings of sensory impairments within SCZ, propelling a nuanced understanding of its heterogeneity.
•Olfactory impairments are widespread in SCZ, with uncertain connections to brain structure changes.•GMV and olfactory function were assessed using the VBM method and OSIT-J, respectively.•Reduced GMV in the right mOFC was significantly related to OSIT-J scores only in the overall SCZ group.•The GMV changes for mOFC in SCZ link to olfactory issues, highlighting the need for deeper neural research.</description><identifier>ISSN: 0278-5846</identifier><identifier>ISSN: 1878-4216</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2024.111204</identifier><identifier>PMID: 39586369</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Gray matter volume ; Medial orbitofrontal cortex ; Olfactory impairment ; Persistent auditory verbal hallucinations ; Schizophrenia</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2025-01, Vol.136, p.111204, Article 111204</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c239t-93dec0ddc9b125246b9d6d470e8a8c4073f7b537c1191c88c1a2bf53e6ba645d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278584624002720$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39586369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Qianjin</creatorcontrib><creatorcontrib>Li, Zongchang</creatorcontrib><creatorcontrib>Li, Jinguang</creatorcontrib><creatorcontrib>He, Ying</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Li, Chunwang</creatorcontrib><creatorcontrib>Chen, Xiaogang</creatorcontrib><creatorcontrib>Tang, Jinsong</creatorcontrib><creatorcontrib>Ren, Honghong</creatorcontrib><title>Volumetric MRI correlates of persistent auditory verbal hallucinations and olfactory identification impairment in chronic schizophrenia: A cross-sectional study</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Olfactory impairments are often observed in schizophrenia (SCZ) patients experiencing persistent auditory verbal hallucinations (pAVHs), yet it remains unclear whether these symptoms share a common neural mechanism with specific brain regions' gray matter volume (GMV) abnormalities. This study aimed to preliminarily elucidate olfactory impairment differences between SCZ patients with and without pAVHs and their correlation with GMV abnormalities in relevant brain regions.
A total of 75 SCZ patients with pAVHs (pAVH group), 56 SCZ patients without AVHs (non-AVH group), and 83 healthy controls (HC group) were examined. Voxel-based morphometry is useful for comparing and analyzing the differences in GMV among three groups. The Odor Stick Identification Test for Japanese (OSIT-J) was harnessed to gauge olfactory abilities.
Olfactory impairments are notably significant across entire SCZ patients compared to HC, with no significant differences in olfactory performance among SCZ subgroups. Notably, the pAVH group demonstrated a significant GMV diminution in the frontal-temporal cortex, starkly contrasting with the non-pAVH and HC groups. Intriguingly, stepwise regression analysis confirmed a strong positive relation between OSIT-J scores and a GMV reduction in the right medial orbitofrontal cortex (mOFC), although this correlation was only observed in the overall SCZ patient group (P < 0.0036, Bonferroni correction).
The GMV perturbations within the mOFC, distinctive to SCZ, may underpin the neuroimaging substrates linked to heightened vulnerability to olfactory impairments in this population. This exploration underscores the imperative of delving into the neural underpinnings of sensory impairments within SCZ, propelling a nuanced understanding of its heterogeneity.
•Olfactory impairments are widespread in SCZ, with uncertain connections to brain structure changes.•GMV and olfactory function were assessed using the VBM method and OSIT-J, respectively.•Reduced GMV in the right mOFC was significantly related to OSIT-J scores only in the overall SCZ group.•The GMV changes for mOFC in SCZ link to olfactory issues, highlighting the need for deeper neural research.</description><subject>Gray matter volume</subject><subject>Medial orbitofrontal cortex</subject><subject>Olfactory impairment</subject><subject>Persistent auditory verbal hallucinations</subject><subject>Schizophrenia</subject><issn>0278-5846</issn><issn>1878-4216</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNp9kcuKFDEUhoMoTs_oEwiSpZtqc6mr4GIY1BkYEUTdhtTJKfo0VUmZVA20T-Ojmu4eXbpKIN9__iQfY6-k2Eoh67f77eznft4qocqtlFKJ8gnbyLZpi1LJ-inbCJX3VVvWF-wypb0QQmqhn7ML3VVtretuw37_COM64RIJ-OevdxxCjDjaBRMPA58xJkoL-oXb1dES4oE_YOztyHd2HFcgbxcKPnHrHQ_jYOHEkMsRGghOp5ym2VKcjmPIc9jF4HNdgh39CvMuoif7jl9ziCGlIiEcQ7kiLas7vGDPBjsmfPm4XrHvHz98u7kt7r98uru5vi9A6W4pOu0QhHPQ9VJVqqz7ztWubAS2toVSNHpo-ko3IGUnoW1BWtUPlca6t3VZOX3F3pznzjH8XDEtZqIEOI7WY1iT0VKrtlSNFBnVZ_R04YiDmSNNNh6MFOaoxuzNSY05qjFnNTn1-rFg7Sd0_zJ_XWTg_RnA_MwHwmgSEHpARzH_iXGB_lvwBxOfpao</recordid><startdate>20250110</startdate><enddate>20250110</enddate><creator>Wang, Qianjin</creator><creator>Li, Zongchang</creator><creator>Li, Jinguang</creator><creator>He, Ying</creator><creator>Zhou, Jun</creator><creator>Li, Chunwang</creator><creator>Chen, Xiaogang</creator><creator>Tang, Jinsong</creator><creator>Ren, Honghong</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20250110</creationdate><title>Volumetric MRI correlates of persistent auditory verbal hallucinations and olfactory identification impairment in chronic schizophrenia: A cross-sectional study</title><author>Wang, Qianjin ; Li, Zongchang ; Li, Jinguang ; He, Ying ; Zhou, Jun ; Li, Chunwang ; Chen, Xiaogang ; Tang, Jinsong ; Ren, Honghong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c239t-93dec0ddc9b125246b9d6d470e8a8c4073f7b537c1191c88c1a2bf53e6ba645d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Gray matter volume</topic><topic>Medial orbitofrontal cortex</topic><topic>Olfactory impairment</topic><topic>Persistent auditory verbal hallucinations</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qianjin</creatorcontrib><creatorcontrib>Li, Zongchang</creatorcontrib><creatorcontrib>Li, Jinguang</creatorcontrib><creatorcontrib>He, Ying</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Li, Chunwang</creatorcontrib><creatorcontrib>Chen, Xiaogang</creatorcontrib><creatorcontrib>Tang, Jinsong</creatorcontrib><creatorcontrib>Ren, Honghong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qianjin</au><au>Li, Zongchang</au><au>Li, Jinguang</au><au>He, Ying</au><au>Zhou, Jun</au><au>Li, Chunwang</au><au>Chen, Xiaogang</au><au>Tang, Jinsong</au><au>Ren, Honghong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Volumetric MRI correlates of persistent auditory verbal hallucinations and olfactory identification impairment in chronic schizophrenia: A cross-sectional study</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2025-01-10</date><risdate>2025</risdate><volume>136</volume><spage>111204</spage><pages>111204-</pages><artnum>111204</artnum><issn>0278-5846</issn><issn>1878-4216</issn><eissn>1878-4216</eissn><abstract>Olfactory impairments are often observed in schizophrenia (SCZ) patients experiencing persistent auditory verbal hallucinations (pAVHs), yet it remains unclear whether these symptoms share a common neural mechanism with specific brain regions' gray matter volume (GMV) abnormalities. This study aimed to preliminarily elucidate olfactory impairment differences between SCZ patients with and without pAVHs and their correlation with GMV abnormalities in relevant brain regions.
A total of 75 SCZ patients with pAVHs (pAVH group), 56 SCZ patients without AVHs (non-AVH group), and 83 healthy controls (HC group) were examined. Voxel-based morphometry is useful for comparing and analyzing the differences in GMV among three groups. The Odor Stick Identification Test for Japanese (OSIT-J) was harnessed to gauge olfactory abilities.
Olfactory impairments are notably significant across entire SCZ patients compared to HC, with no significant differences in olfactory performance among SCZ subgroups. Notably, the pAVH group demonstrated a significant GMV diminution in the frontal-temporal cortex, starkly contrasting with the non-pAVH and HC groups. Intriguingly, stepwise regression analysis confirmed a strong positive relation between OSIT-J scores and a GMV reduction in the right medial orbitofrontal cortex (mOFC), although this correlation was only observed in the overall SCZ patient group (P < 0.0036, Bonferroni correction).
The GMV perturbations within the mOFC, distinctive to SCZ, may underpin the neuroimaging substrates linked to heightened vulnerability to olfactory impairments in this population. This exploration underscores the imperative of delving into the neural underpinnings of sensory impairments within SCZ, propelling a nuanced understanding of its heterogeneity.
•Olfactory impairments are widespread in SCZ, with uncertain connections to brain structure changes.•GMV and olfactory function were assessed using the VBM method and OSIT-J, respectively.•Reduced GMV in the right mOFC was significantly related to OSIT-J scores only in the overall SCZ group.•The GMV changes for mOFC in SCZ link to olfactory issues, highlighting the need for deeper neural research.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>39586369</pmid><doi>10.1016/j.pnpbp.2024.111204</doi></addata></record> |
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| subjects | Gray matter volume Medial orbitofrontal cortex Olfactory impairment Persistent auditory verbal hallucinations Schizophrenia |
| title | Volumetric MRI correlates of persistent auditory verbal hallucinations and olfactory identification impairment in chronic schizophrenia: A cross-sectional study |
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