Mitochondrial DNA (mtDNA) accelerates oxygen-glucose deprivation-induced injury of proximal tubule epithelia cell via inhibiting NLRC5

•OGD/R contributed to the production mtDNA.•mtDNA aggravated inflammation and apoptosis.•mtDNA promoted NLRC5 expression. The high morbidity and mortality associated with acute kidney injury (AKI) are global health concerns. AKI is commonly attributed to ischemia/reperfusion injury (IRI), a conditio...

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Veröffentlicht in:	Mitochondrion 2025-03, Vol.81, p.101989, Article 101989
Hauptverfasser:	Ge, Guojun, Zhu, Bocheng, Zhu, Xiaofeng, Yu, Zhenfei, Zhu, Keqing, Cheng, Mengshi
Format:	Artikel
Sprache:	eng
Schlagworte:	AKI mtDNA NLRC5 OGD/R
Online-Zugang:	Volltext
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