ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation

Tubulointerstitial fibrosis in the kidneys is a chronic and progressive process. Although studies suggested that tubular epithelial-mesenchymal transition (EMT) plays a key role in the development of kidney fibrosis, whether ACVR1, a member of the TGFβ superfamily, is involved in the EMT needs to be...

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Veröffentlicht in:	Cellular signalling 2025-01, Vol.125, p.111521, Article 111521
Hauptverfasser:	Yu, Tianli, Mai, Zhangyu, Zhang, Shunhui, Wang, Shunyi, Yang, Wenjin, Ruan, Zhang, Li, Pinxian, Guo, Fujia, Zhang, Yining, Li, Jiangchao, Wang, Lijing, Lin, Caixia, Zheng, Lingyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors, Type I - genetics Activin Receptors, Type I - metabolism ACVR1 Animals Cell Line Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial-Mesenchymal Transition Fibrosis Heterocyclic Compounds, 3-Ring - pharmacology HK-2 cell Humans Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Tubules - metabolism Kidney Tubules - pathology Male Mice Mice, Inbred C57BL Phosphatidylinositol 3-Kinases - metabolism Phosphorylation PI3K/AKT Proto-Oncogene Proteins c-akt - metabolism Renal tubular epithelium Signal Transduction Transforming Growth Factor beta1 - metabolism Vimentin - metabolism
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