Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis
Purpose of Review Once prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating bone metastasis remain elusive. This review will explore recent findings related to cytokines and chemokines in the process of bone metastases. Recent Findings...
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| Veröffentlicht in: | Current osteoporosis reports 2025-12, Vol.23 (1), p.3, Article 3 |
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| creator | Shiozawa, Yusuke Parajuli, Keshab Raj Pienta, Kenneth Taichman, Russell |
| description | Purpose of Review
Once prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating bone metastasis remain elusive. This review will explore recent findings related to cytokines and chemokines in the process of bone metastases.
Recent Findings
We discuss the role of cytokines in tumor growth, invasion, bone remodelling and angiogenesis and immune regulation in PCa skeletal metastases. Major advances in our understanding focus on immune evasion, immune checkpoint blockade, tumor-associated macrophages (TAMs), CAR-T cells, cytokine regulation of matrix metalloproteinases, cytokines including IL-10, IL-27, Interferon-γ, prostate transmembrane protein androgen induced 1 (Pmepa1), and regulation of RUNX2 transcription in supporting survival and growth of disseminated tumor cells (DTCs) and metastases development.
Summary
The review highlights the complexity of cytokine actions in PCa bone metastases, suggesting potential therapeutic targets to disrupt interactions between cancer cells and their microenvironment. |
| doi_str_mv | 10.1007/s11914-024-00897-9 |
| format | Article |
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Once prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating bone metastasis remain elusive. This review will explore recent findings related to cytokines and chemokines in the process of bone metastases.
Recent Findings
We discuss the role of cytokines in tumor growth, invasion, bone remodelling and angiogenesis and immune regulation in PCa skeletal metastases. Major advances in our understanding focus on immune evasion, immune checkpoint blockade, tumor-associated macrophages (TAMs), CAR-T cells, cytokine regulation of matrix metalloproteinases, cytokines including IL-10, IL-27, Interferon-γ, prostate transmembrane protein androgen induced 1 (Pmepa1), and regulation of RUNX2 transcription in supporting survival and growth of disseminated tumor cells (DTCs) and metastases development.
Summary
The review highlights the complexity of cytokine actions in PCa bone metastases, suggesting potential therapeutic targets to disrupt interactions between cancer cells and their microenvironment.</description><identifier>ISSN: 1544-1873</identifier><identifier>ISSN: 1544-2241</identifier><identifier>EISSN: 1544-2241</identifier><identifier>DOI: 10.1007/s11914-024-00897-9</identifier><identifier>PMID: 39585513</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bone Neoplasms - immunology ; Bone Neoplasms - metabolism ; Bone Neoplasms - secondary ; Bone Remodeling - physiology ; Chemokines - metabolism ; Core Binding Factor Alpha 1 Subunit - metabolism ; Cytokines - metabolism ; Epidemiology ; Humans ; Interferon-gamma - metabolism ; Interleukin-10 - metabolism ; Male ; Matrix Metalloproteinases - metabolism ; Medicine ; Medicine & Public Health ; Neovascularization, Pathologic ; Orthopedics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Review ; Topical Collection on Craniofacial Skeleton ; Tumor Microenvironment - immunology ; Tumor-Associated Macrophages - immunology ; Tumor-Associated Macrophages - metabolism</subject><ispartof>Current osteoporosis reports, 2025-12, Vol.23 (1), p.3, Article 3</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-1abac70e44a7eba13edf1333badecd008bdf57e8aa581c5a58c8bfa0977338b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11914-024-00897-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11914-024-00897-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,41490,42559,51321</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39585513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shiozawa, Yusuke</creatorcontrib><creatorcontrib>Parajuli, Keshab Raj</creatorcontrib><creatorcontrib>Pienta, Kenneth</creatorcontrib><creatorcontrib>Taichman, Russell</creatorcontrib><title>Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis</title><title>Current osteoporosis reports</title><addtitle>Curr Osteoporos Rep</addtitle><addtitle>Curr Osteoporos Rep</addtitle><description>Purpose of Review
Once prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating bone metastasis remain elusive. This review will explore recent findings related to cytokines and chemokines in the process of bone metastases.
Recent Findings
We discuss the role of cytokines in tumor growth, invasion, bone remodelling and angiogenesis and immune regulation in PCa skeletal metastases. Major advances in our understanding focus on immune evasion, immune checkpoint blockade, tumor-associated macrophages (TAMs), CAR-T cells, cytokine regulation of matrix metalloproteinases, cytokines including IL-10, IL-27, Interferon-γ, prostate transmembrane protein androgen induced 1 (Pmepa1), and regulation of RUNX2 transcription in supporting survival and growth of disseminated tumor cells (DTCs) and metastases development.
Summary
The review highlights the complexity of cytokine actions in PCa bone metastases, suggesting potential therapeutic targets to disrupt interactions between cancer cells and their microenvironment.</description><subject>Bone Neoplasms - immunology</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - secondary</subject><subject>Bone Remodeling - physiology</subject><subject>Chemokines - metabolism</subject><subject>Core Binding Factor Alpha 1 Subunit - metabolism</subject><subject>Cytokines - metabolism</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Interferon-gamma - metabolism</subject><subject>Interleukin-10 - metabolism</subject><subject>Male</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neovascularization, Pathologic</subject><subject>Orthopedics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Review</subject><subject>Topical Collection on Craniofacial Skeleton</subject><subject>Tumor Microenvironment - immunology</subject><subject>Tumor-Associated Macrophages - immunology</subject><subject>Tumor-Associated Macrophages - metabolism</subject><issn>1544-1873</issn><issn>1544-2241</issn><issn>1544-2241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxhQRpaAz3ZqZ0QRFKQiEB-z5TgXSJsmxU6G_ntcEhgZ7sO69175HkLOgV4BpfLaA6QgYspCUJXKOD0gU0iEiBkTcDj2oCSfkBPvV5QyBoIfkwlPE5UkwKdk8dLWGLVllH3ipl1XDfrINEWU7brxVTXRs2t9ZzqMMtNYdNHrGmvsTB09hhwmvvKn5Kg0tcezsc7I-93tW3YfL58WD9nNMraMqS4GkxsrKQphJOYGOBYlcM5zU6AtwhV5USYSlTGJApuEbFVeGppKybnKBZ-Ry8F369qvHn2nN5W3WNemwbb3mgNnc2BzupeyQWrD973DUm9dtTFup4HqPUA9ANQBoP4BqNOwdDH69_kGi7-VX2JBwAeBD6PmA51etb1rws3_2X4DUVZ7-w</recordid><startdate>20251201</startdate><enddate>20251201</enddate><creator>Shiozawa, Yusuke</creator><creator>Parajuli, Keshab Raj</creator><creator>Pienta, Kenneth</creator><creator>Taichman, Russell</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20251201</creationdate><title>Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis</title><author>Shiozawa, Yusuke ; Parajuli, Keshab Raj ; Pienta, Kenneth ; Taichman, Russell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-1abac70e44a7eba13edf1333badecd008bdf57e8aa581c5a58c8bfa0977338b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Bone Neoplasms - immunology</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - secondary</topic><topic>Bone Remodeling - physiology</topic><topic>Chemokines - metabolism</topic><topic>Core Binding Factor Alpha 1 Subunit - metabolism</topic><topic>Cytokines - metabolism</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Interferon-gamma - metabolism</topic><topic>Interleukin-10 - metabolism</topic><topic>Male</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neovascularization, Pathologic</topic><topic>Orthopedics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Review</topic><topic>Topical Collection on Craniofacial Skeleton</topic><topic>Tumor Microenvironment - immunology</topic><topic>Tumor-Associated Macrophages - immunology</topic><topic>Tumor-Associated Macrophages - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiozawa, Yusuke</creatorcontrib><creatorcontrib>Parajuli, Keshab Raj</creatorcontrib><creatorcontrib>Pienta, Kenneth</creatorcontrib><creatorcontrib>Taichman, Russell</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current osteoporosis reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiozawa, Yusuke</au><au>Parajuli, Keshab Raj</au><au>Pienta, Kenneth</au><au>Taichman, Russell</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis</atitle><jtitle>Current osteoporosis reports</jtitle><stitle>Curr Osteoporos Rep</stitle><addtitle>Curr Osteoporos Rep</addtitle><date>2025-12-01</date><risdate>2025</risdate><volume>23</volume><issue>1</issue><spage>3</spage><pages>3-</pages><artnum>3</artnum><issn>1544-1873</issn><issn>1544-2241</issn><eissn>1544-2241</eissn><abstract>Purpose of Review
Once prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating bone metastasis remain elusive. This review will explore recent findings related to cytokines and chemokines in the process of bone metastases.
Recent Findings
We discuss the role of cytokines in tumor growth, invasion, bone remodelling and angiogenesis and immune regulation in PCa skeletal metastases. Major advances in our understanding focus on immune evasion, immune checkpoint blockade, tumor-associated macrophages (TAMs), CAR-T cells, cytokine regulation of matrix metalloproteinases, cytokines including IL-10, IL-27, Interferon-γ, prostate transmembrane protein androgen induced 1 (Pmepa1), and regulation of RUNX2 transcription in supporting survival and growth of disseminated tumor cells (DTCs) and metastases development.
Summary
The review highlights the complexity of cytokine actions in PCa bone metastases, suggesting potential therapeutic targets to disrupt interactions between cancer cells and their microenvironment.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39585513</pmid><doi>10.1007/s11914-024-00897-9</doi></addata></record> |
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| ispartof | Current osteoporosis reports, 2025-12, Vol.23 (1), p.3, Article 3 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Bone Neoplasms - immunology Bone Neoplasms - metabolism Bone Neoplasms - secondary Bone Remodeling - physiology Chemokines - metabolism Core Binding Factor Alpha 1 Subunit - metabolism Cytokines - metabolism Epidemiology Humans Interferon-gamma - metabolism Interleukin-10 - metabolism Male Matrix Metalloproteinases - metabolism Medicine Medicine & Public Health Neovascularization, Pathologic Orthopedics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Review Topical Collection on Craniofacial Skeleton Tumor Microenvironment - immunology Tumor-Associated Macrophages - immunology Tumor-Associated Macrophages - metabolism |
| title | Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis |
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