Childhood, adolescent and young adulthood cancer risk in BRCA1 or BRCA2 pathogenic variant carriers

Whether carriers of BRCA1 or BRCA2 (BRCA1/2) pathogenic variants (PVs) have increased risks of childhood, adolescent, and young adult (CAYA) cancers is controversial. We aimed to evaluate this risk and to inform clinical care of young BRCA1/2 PV carriers and genetic testing for CAYA cancer patients....

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2024-11
Hauptverfasser:	Li, Shuai, Madanat-Harjuoja, Laura, Leslie, Goska, Barnes, Daniel R, Bolla, Manjeet K, Dennis, Joe, Parsons, Michael T, Apostolou, Paraskevi, Arnold, Norbert, Bosse, Kristin, On Behalf Of Embrace Collaborators, Antonis C Antoniou, Cook, Jackie, Engel, Christoph, Evans, D Gareth, Fostira, Florentia, Frone, Megan N, Gehrig, Andrea, Greene, Mark H, Hackmann, Karl, Hahnen, Eric, Harbeck, Nadia, Hauke, Jan, Hentschel, Julia, Horvath, Judit, Izatt, Louise, Kiechle, Marion, Konstantopoulou, Irene, Lalloo, Fiona, Yie, Joanne Ngeow Yuen, Niederacher, Dieter, Ritter, Julia, Santamariña, Marta, Schmutzler, Rita K, Searle, Claire, Sutter, Christian, Tischkowitz, Marc, Tripathi, Vishakha, Vega, Ana, Wallaschek, Hannah, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weber, Bernhard H F, Yannoukakos, Drakoulis, Zhao, Emily, Easton, Douglas F, Antoniou, Antonis C, Chenevix-Trench, Georgia, Rebbeck, Timothy R, Diller, Lisa R
Format:	Artikel
Sprache:	eng
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