In silicon desinging of RANKL-targeting vaccine for protection of osteoporosis based on the epitope of Denosumab

•RANKL-Denosumab binding peptide (RANKL220–245) was firstly identified.•DR3 vaccine was constructed by three copies of RANKL220–245 and diphtheria toxin T domain.•DR3 vaccine could activate T and B lymphocytes to produce high levels of antibodies and cytokines like IFN- γ, IL-2 and etc.•DR3 vaccine...

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Veröffentlicht in:	International immunopharmacology 2025-01, Vol.144, p.113610, Article 113610
Hauptverfasser:	Wu, Tailin, Guan, Bin, Luo, Jianzhou, Li, Lin, Zhang, Bobo, Yang, Zili, Tan, Lei, Tao, Huiren
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Denosumab - therapeutic use Disease Models, Animal Epitopes - immunology Female Humans Mice Mice, Transgenic Osteoporosis - immunology Osteoporosis - prevention & control RANK Ligand - immunology Vaccines - immunology
Online-Zugang:	Volltext
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