Novel pof1 mutation suppresses the sensitivity to DNA replication inhibitor in fission yeast RecQ helicase mutant

Homologous recombination is vital for DNA double-strand break repair. Dysfunction in homologous recombination can lead to cell death, mutations, and cancer. In fission yeast (Schizosaccharomyces pombe), RecQ helicase Rqh1 resolves recombination intermediates. We found that rqh1-hd strain impaired gr...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-12, Vol.741, p.151014, Article 151014
Hauptverfasser:	Tang, Jiashen, Nakamura, Mikio, Ng, Wai Yee, Feng, Naiwen, Ueno, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	BLM helicases DNA Helicases DNA repair DNA Replication - drug effects Homologous recombination Homologous Recombination - drug effects Hydroxyurea Hydroxyurea - pharmacology Mutation Nucleic Acid Synthesis Inhibitors - pharmacology Pof1 RecQ Helicases - genetics RecQ Helicases - metabolism Rqh1 Schizosaccharomyces - drug effects Schizosaccharomyces - genetics Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Thiabendazole - pharmacology
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