Automatic vessel segmentation and reformation of non-contrast coronary magnetic resonance angiography using transfer learning-based three-dimensional U-net with attention mechanism

Coronary magnetic resonance angiography (CMRA) presents distinct advantages, but its reliance on manual image post-processing is labor-intensive and requires specialized knowledge. This study aims to design and test an efficient artificial intelligence (AI) model capable of automating coronary artery segmentation and reformation from CMRA images for coronary artery disease (CAD) diagnosis. By leveraging transfer learning from a pre-existing coronary computed tomography angiography model, a three-dimensional attention-aware U-Net was established, trained, and validated on a dataset of 104 subjects’ CMRA. Furthermore, an independent clinical evaluation was conducted on an additional cohort of 70 patients. The AI model's performance in segmenting coronary arteries was assessed using the Dice similarity coefficient (DSC) and recall. The comparison between the AI model and manual processing by experienced radiologists on vessel reformation was based on reformatted image quality (rIQ) scoring, post-processing time, and the number of necessary user interactions. The diagnostic performance of AI-segmented CMRA for significant stenosis (≥50% diameter reduction) was evaluated using conventional coronary angiography (CAG) as a reference in sub-set data. The DSC of the AI model achieved on the training and validation sets were 0.952 and 0.944, with recalls of 0.936 and 0.923, respectively. In the clinical evaluation, the model outperformed manual processes by reducing vessel post-processing time, from 632.6±17.0 s to 77.4±8.9 s, and the number of user interactions from 221±59 to 8±2. The AI post-processed images maintained high rIQ scores comparable to those processed manually (2.7±0.8 vs 2.7±0.6; P = 0.4806). In subjects with CAG, the prevalence of CAD was 71%. The sensitivity, specificity, and accuracy at patient-based analysis were 94%, 71%, and 88%, respectively, by AI post-processed whole-heart CMRA. The AI auto-segmentation system can effectively facilitate CMRA vessel reformation and reduce the time consumption for radiologists. It has the potential to become a standard component of daily workflows, optimizing the clinical application of CMRA in the future. [Display omitted]