Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care
To evaluate the accuracy of a device for continuous glucose monitoring (CGM) among infants born preterm admitted to the neonatal intensive care unit. We analyzed paired CGM sensor glucose (SG) and point-of-care blood glucose (BG) measurements collected in infants born at ≤32 weeks of gestation or wi...
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| Veröffentlicht in: | The Journal of pediatrics 2025-03, Vol.278, p.114416, Article 114416 |
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| container_title | The Journal of pediatrics |
| container_volume | 278 |
| creator | Bonet, Jacopo Guiducci, Silvia Res, Giulia Brigadoi, Sabrina Sen, Sarbattama Montaldo, Paolo Priante, Elena Santoro, Nicola Trevisanuto, Daniele Baraldi, Eugenio Dalla Man, Chiara Galderisi, Alfonso |
| description | To evaluate the accuracy of a device for continuous glucose monitoring (CGM) among infants born preterm admitted to the neonatal intensive care unit.
We analyzed paired CGM sensor glucose (SG) and point-of-care blood glucose (BG) measurements collected in infants born at ≤32 weeks of gestation or with a birth weight ≤1500 g. CGM was initiated within 48 hours from birth and maintained for 5 days. BG was performed every 12 hours and used to calibrate the sensor. Measures of CGM accuracy were computed from SG and BG pairs.
We included 501 SG-BG paired measurements from 51 infants (age 30.5 weeks [IQR 29.0-31.0 weeks], birth weight 1400 g [IQR 1100-1500 g] with at least 24 hours of CGM data. The mean absolute relative difference (MARD) between SG and point-of-care BG measures was 7.1% [IQR 5.6-9.3], corresponding to a difference of −5.6 mg/dL [95% CI −25 to +14 mg/dl]. The median sensor use was 96 hours [IQR 72-120] with 2.0 [IQR 1.7-2.4] calibrations per day.
Accuracy of SG measurements compared with BG measurements appears to be acceptable in a clinical study setting, with a negligible difference between SG and BG. Our data suggest that SG use may be clinically acceptable when the sensor is regularly calibrated. |
| doi_str_mv | 10.1016/j.jpeds.2024.114416 |
| format | Article |
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We analyzed paired CGM sensor glucose (SG) and point-of-care blood glucose (BG) measurements collected in infants born at ≤32 weeks of gestation or with a birth weight ≤1500 g. CGM was initiated within 48 hours from birth and maintained for 5 days. BG was performed every 12 hours and used to calibrate the sensor. Measures of CGM accuracy were computed from SG and BG pairs.
We included 501 SG-BG paired measurements from 51 infants (age 30.5 weeks [IQR 29.0-31.0 weeks], birth weight 1400 g [IQR 1100-1500 g] with at least 24 hours of CGM data. The mean absolute relative difference (MARD) between SG and point-of-care BG measures was 7.1% [IQR 5.6-9.3], corresponding to a difference of −5.6 mg/dL [95% CI −25 to +14 mg/dl]. The median sensor use was 96 hours [IQR 72-120] with 2.0 [IQR 1.7-2.4] calibrations per day.
Accuracy of SG measurements compared with BG measurements appears to be acceptable in a clinical study setting, with a negligible difference between SG and BG. Our data suggest that SG use may be clinically acceptable when the sensor is regularly calibrated.</description><identifier>ISSN: 0022-3476</identifier><identifier>ISSN: 1097-6833</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2024.114416</identifier><identifier>PMID: 39579867</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>CGM ; glucose monitoring ; preterm infants</subject><ispartof>The Journal of pediatrics, 2025-03, Vol.278, p.114416, Article 114416</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c239t-1cf170f7ec97226ba33eb4a7e505ca859d3667c34a3b40f4e1ef7fdb48a70383</cites><orcidid>0000-0001-8885-3056</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347624005195$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39579867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonet, Jacopo</creatorcontrib><creatorcontrib>Guiducci, Silvia</creatorcontrib><creatorcontrib>Res, Giulia</creatorcontrib><creatorcontrib>Brigadoi, Sabrina</creatorcontrib><creatorcontrib>Sen, Sarbattama</creatorcontrib><creatorcontrib>Montaldo, Paolo</creatorcontrib><creatorcontrib>Priante, Elena</creatorcontrib><creatorcontrib>Santoro, Nicola</creatorcontrib><creatorcontrib>Trevisanuto, Daniele</creatorcontrib><creatorcontrib>Baraldi, Eugenio</creatorcontrib><creatorcontrib>Dalla Man, Chiara</creatorcontrib><creatorcontrib>Galderisi, Alfonso</creatorcontrib><title>Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To evaluate the accuracy of a device for continuous glucose monitoring (CGM) among infants born preterm admitted to the neonatal intensive care unit.
We analyzed paired CGM sensor glucose (SG) and point-of-care blood glucose (BG) measurements collected in infants born at ≤32 weeks of gestation or with a birth weight ≤1500 g. CGM was initiated within 48 hours from birth and maintained for 5 days. BG was performed every 12 hours and used to calibrate the sensor. Measures of CGM accuracy were computed from SG and BG pairs.
We included 501 SG-BG paired measurements from 51 infants (age 30.5 weeks [IQR 29.0-31.0 weeks], birth weight 1400 g [IQR 1100-1500 g] with at least 24 hours of CGM data. The mean absolute relative difference (MARD) between SG and point-of-care BG measures was 7.1% [IQR 5.6-9.3], corresponding to a difference of −5.6 mg/dL [95% CI −25 to +14 mg/dl]. The median sensor use was 96 hours [IQR 72-120] with 2.0 [IQR 1.7-2.4] calibrations per day.
Accuracy of SG measurements compared with BG measurements appears to be acceptable in a clinical study setting, with a negligible difference between SG and BG. Our data suggest that SG use may be clinically acceptable when the sensor is regularly calibrated.</description><subject>CGM</subject><subject>glucose monitoring</subject><subject>preterm infants</subject><issn>0022-3476</issn><issn>1097-6833</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOwzAUhi0EgnJ5AiTkkSXFjp04QWKACgoStwGxWo5zjFwldrGdSn17UgqMLOcs_0X_h9ApJVNKaHmxmC6W0MZpTnI-pZRzWu6gCSW1yMqKsV00ISTPM8ZFeYAOY1wQQmpOyD46YHUh6qoUE-Rn3iXrBj9EPO8G7SPgJ-9s8sG6D6x6P94HZ5RLEd_44PA7hDV-DZAg9Jf4dmVbcBqw8QFfaz0EpdfYOvwM3qmkutGcwEW7AjxTAY7RnlFdhJOff4Te7m7fZvfZ48v8YXb9mOmc1Smj2lBBjABdizwvG8UYNFwJKEihVVXULStLoRlXrOHEcKBghGkbXilBWMWO0Pk2dhn85wAxyd5GDV2nHIxTJaMsHxMKzkYp20p18DEGMHIZbK_CWlIiN6DlQn6DlhvQcgt6dJ39FAxND-2f55fsKLjaCmBcubIQZNR2Q6q1AXSSrbf_FnwBRUCQ1w</recordid><startdate>20250301</startdate><enddate>20250301</enddate><creator>Bonet, Jacopo</creator><creator>Guiducci, Silvia</creator><creator>Res, Giulia</creator><creator>Brigadoi, Sabrina</creator><creator>Sen, Sarbattama</creator><creator>Montaldo, Paolo</creator><creator>Priante, Elena</creator><creator>Santoro, Nicola</creator><creator>Trevisanuto, Daniele</creator><creator>Baraldi, Eugenio</creator><creator>Dalla Man, Chiara</creator><creator>Galderisi, Alfonso</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8885-3056</orcidid></search><sort><creationdate>20250301</creationdate><title>Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care</title><author>Bonet, Jacopo ; Guiducci, Silvia ; Res, Giulia ; Brigadoi, Sabrina ; Sen, Sarbattama ; Montaldo, Paolo ; Priante, Elena ; Santoro, Nicola ; Trevisanuto, Daniele ; Baraldi, Eugenio ; Dalla Man, Chiara ; Galderisi, Alfonso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c239t-1cf170f7ec97226ba33eb4a7e505ca859d3667c34a3b40f4e1ef7fdb48a70383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>CGM</topic><topic>glucose monitoring</topic><topic>preterm infants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonet, Jacopo</creatorcontrib><creatorcontrib>Guiducci, Silvia</creatorcontrib><creatorcontrib>Res, Giulia</creatorcontrib><creatorcontrib>Brigadoi, Sabrina</creatorcontrib><creatorcontrib>Sen, Sarbattama</creatorcontrib><creatorcontrib>Montaldo, Paolo</creatorcontrib><creatorcontrib>Priante, Elena</creatorcontrib><creatorcontrib>Santoro, Nicola</creatorcontrib><creatorcontrib>Trevisanuto, Daniele</creatorcontrib><creatorcontrib>Baraldi, Eugenio</creatorcontrib><creatorcontrib>Dalla Man, Chiara</creatorcontrib><creatorcontrib>Galderisi, Alfonso</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonet, Jacopo</au><au>Guiducci, Silvia</au><au>Res, Giulia</au><au>Brigadoi, Sabrina</au><au>Sen, Sarbattama</au><au>Montaldo, Paolo</au><au>Priante, Elena</au><au>Santoro, Nicola</au><au>Trevisanuto, Daniele</au><au>Baraldi, Eugenio</au><au>Dalla Man, Chiara</au><au>Galderisi, Alfonso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2025-03-01</date><risdate>2025</risdate><volume>278</volume><spage>114416</spage><pages>114416-</pages><artnum>114416</artnum><issn>0022-3476</issn><issn>1097-6833</issn><eissn>1097-6833</eissn><abstract>To evaluate the accuracy of a device for continuous glucose monitoring (CGM) among infants born preterm admitted to the neonatal intensive care unit.
We analyzed paired CGM sensor glucose (SG) and point-of-care blood glucose (BG) measurements collected in infants born at ≤32 weeks of gestation or with a birth weight ≤1500 g. CGM was initiated within 48 hours from birth and maintained for 5 days. BG was performed every 12 hours and used to calibrate the sensor. Measures of CGM accuracy were computed from SG and BG pairs.
We included 501 SG-BG paired measurements from 51 infants (age 30.5 weeks [IQR 29.0-31.0 weeks], birth weight 1400 g [IQR 1100-1500 g] with at least 24 hours of CGM data. The mean absolute relative difference (MARD) between SG and point-of-care BG measures was 7.1% [IQR 5.6-9.3], corresponding to a difference of −5.6 mg/dL [95% CI −25 to +14 mg/dl]. The median sensor use was 96 hours [IQR 72-120] with 2.0 [IQR 1.7-2.4] calibrations per day.
Accuracy of SG measurements compared with BG measurements appears to be acceptable in a clinical study setting, with a negligible difference between SG and BG. Our data suggest that SG use may be clinically acceptable when the sensor is regularly calibrated.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39579867</pmid><doi>10.1016/j.jpeds.2024.114416</doi><orcidid>https://orcid.org/0000-0001-8885-3056</orcidid></addata></record> |
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| subjects | CGM glucose monitoring preterm infants |
| title | Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care |
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