Altering fractionation during radiation overcomes radio-resistance in patient-derived glioblastoma cells assessed using a novel longitudinal radiation cytotoxicity assay

[Display omitted] •Theoretical in-silico modeling was used to predict in vitro radiation cytotoxicity.•Advanced imaging strategies were used to assess radiosensitivity longitudinally.•Radiation dose order differentially impacts radioresistant and radiosensitive PDX.•Ramping down dose induces cytotox...

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Veröffentlicht in:	Radiotherapy and oncology 2025-01, Vol.202, p.110646, Article 110646
Hauptverfasser:	Nassour-Caswell, Lauren C., Kumar, Manoj, Stackhouse, Christian T., Alrefai, Hasan, Schanel, Taylor L., Honan, Benjamin M., Beierle, Andee M., Hicks, Patricia H., Anderson, Joshua C., Willey, Christopher D., Peacock, Jeffrey S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - pathology Brain Neoplasms - radiotherapy BTIC Cell viability Dose Fractionation, Radiation Glioblastoma Glioblastoma - pathology Glioblastoma - radiotherapy Humans Mice Radiation Tolerance Radiosensitivity Xenograft
Online-Zugang:	Volltext
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