Isorhapontigenin alleviates acetaminophen-induced liver injury by promoting fatty acid oxidation

Acetaminophen (APAP) is a widely used analgesic and antipyretic medicine. It is frequently employed to alleviate pain and mitigate fever-related symptoms, but it can cause liver injury or even liver failure when overdosed. Isorhapontigenin, a compound derived from Chinese herbs and grapes, has been...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2025-02, Vol.1871 (2), p.167575, Article 167575
Hauptverfasser:	Zha, Huiyan, Lv, Shuying, Hu, Yuming, Xie, Yaochen, Wang, Lingkun, Yang, Chen, Li, Guilin, Gong, Shuchen, Ping, Li, Zhu, Difeng, Wang, Jiajia, Weng, Qinjie, He, Qiaojun, Wang, Jincheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - adverse effects Animals Apoptosis - drug effects Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Fatty acid oxidation Fatty Acids - metabolism Isorhapontigenin Liver - drug effects Liver - injuries Liver - metabolism Liver - pathology Liver injury Male Mice Mice, Inbred C57BL Oxidation-Reduction - drug effects Oxidative Stress - drug effects Stilbenes
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