Ultra-sensitive DNA detection with single-base mismatch resolution using a tapered thin-diameter photonic crystal fiber interferometer

A tapered thin-diameter photonic crystal fiber interferometer (TTD-PCFI) biosensor is proposed and demonstrated for DNA hybridization detection with an ultra-low limit of detection (LoD) and high specificity. The TTD-PCFI is fabricated by arc-discharged melting and adiabatic tapering, with a lower l...

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Veröffentlicht in:	Optics express 2024-08, Vol.32 (18), p.31514
Hauptverfasser:	Wan, Hongdan, Chen, Xinyu, Zhang, Shutong, Xiong, Jinxin, Jiang, Weifeng, Liu, Haozhuo, Wan, Cheng, Wang, Jingli, Xiao, Ying, Wu, Zhuojin, Chao, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pair Mismatch Biosensing Techniques - instrumentation DNA - analysis Equipment Design Fiber Optic Technology - instrumentation Interferometry - instrumentation Limit of Detection Nucleic Acid Hybridization Optical Fibers Photons Refractometry - instrumentation
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