Anti-asthmatic and antioxidant activity of flavonoids isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on ovalbumin-induced allergic asthma in mice: In-vivo and in-silico study
Mentha longifolia L. has been employed to treat cough, lung inflammation, and bronchial asthma disorders. Our study was carried out to investigate the medicinal effect of the flavonoids derived from M. longifolia, specifically didymin, linarin, rutin, and TMF, as well as the whole extracts of M. lon...
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| creator | Haikal, Abdullah El-Neketi, Mona Helal, Manar G. Abou-zeid, Laila A. Hassan, Madiha A. Gohar, Ahmed A. |
| description | Mentha longifolia L. has been employed to treat cough, lung inflammation, and bronchial asthma disorders.
Our study was carried out to investigate the medicinal effect of the flavonoids derived from M. longifolia, specifically didymin, linarin, rutin, and TMF, as well as the whole extracts of M. longifolia subsp. typhoides and M. longifolia subsp. schimperi, in comparison to dexa, in a mice model of ovalbumin-allergic asthma (OVA).
After inhaling OVA, the mice developed acute asthma symptoms. Mice were subjected orally to Dexa and/or isolated flavonoids. The study assessed total and differential leukocyte counts, LDH concentration, and total protein concentration in BALF, reduced levels of GSH and total NOx products in lung tissues and analyzed the lung specimens by staining them with hematoxylin and eosin (H & E).
Histopathological analysis of the right lung lobes demonstrated that the isolated flavonoids exhibited a significant anti-inflammatory effect higher than Dexa as shown by decreasing the overall and distinct leukocyte counts, LDH levels, and total protein levels in BALF, as compared to the OVA group (p |
| doi_str_mv | 10.1016/j.jep.2024.119133 |
| format | Article |
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Our study was carried out to investigate the medicinal effect of the flavonoids derived from M. longifolia, specifically didymin, linarin, rutin, and TMF, as well as the whole extracts of M. longifolia subsp. typhoides and M. longifolia subsp. schimperi, in comparison to dexa, in a mice model of ovalbumin-allergic asthma (OVA).
After inhaling OVA, the mice developed acute asthma symptoms. Mice were subjected orally to Dexa and/or isolated flavonoids. The study assessed total and differential leukocyte counts, LDH concentration, and total protein concentration in BALF, reduced levels of GSH and total NOx products in lung tissues and analyzed the lung specimens by staining them with hematoxylin and eosin (H & E).
Histopathological analysis of the right lung lobes demonstrated that the isolated flavonoids exhibited a significant anti-inflammatory effect higher than Dexa as shown by decreasing the overall and distinct leukocyte counts, LDH levels, and total protein levels in BALF, as compared to the OVA group (p < 0.05). TMF was the most effective and the other tested flavonoids are more effective than Dexa but less than TMF. In addition, all tested flavonoids and Dexa significantly (p < 0.05) mitigated OVA-induced oxidative stress as evidenced by diminished lung NOx level and elevated GSH level. Computational docking studies proved recognition of didymin, linarin, rutin, and TMF to the human leukocyte elastase binding sites.
The tested flavonoids; didymin, linarin, rutin, and TMF successfully inhibit Ova-induced allergic asthma in mice through their anti-inflammatory and antioxidant activities and may represent promising candidate as a remedy for allergic asthma.
[Display omitted]
•Exploring the anti-asthma activity of the methanol extract of Mentha longifolia on ovalbumin-induced allergic asthma in mice, together with some pure flavonoids (didymin, linarin, rutin and tetramethoxyflavone).•Clarifying the mechanism of anti-ashmatic activity; significant reduction of differential leukocytic count, total protein content, and LDH activity in BALF, increase in GSH concentration, and decrease in NOx concentration.•Histopathological examination of the lung tissues under the effect of OVA and suggested drugs.•In-silico study to correlate the active substances protein-binding affinity to the results of the in vivo study.</description><identifier>ISSN: 0378-8741</identifier><identifier>ISSN: 1872-7573</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2024.119133</identifier><identifier>PMID: 39571699</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Animals ; Anti-Asthmatic Agents - isolation & purification ; Anti-Asthmatic Agents - pharmacology ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Asthma - chemically induced ; Asthma - drug therapy ; Bronchoalveolar Lavage Fluid ; Didymin ; Disease Models, Animal ; Female ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; Linarin ; Lung - drug effects ; Lung - metabolism ; Lung - pathology ; M. longifolia ; Male ; Mentha - chemistry ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Ovalbumin ; Ovalbumin allergic asthma ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Rutin ; Tetramethoxyflavone</subject><ispartof>Journal of ethnopharmacology, 2025-01, Vol.339, p.119133, Article 119133</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c235t-d605a0092bcc2a7090b318868982a24a6e81acbd21456ea8d4c8ae8623f69e703</cites><orcidid>0000-0003-2608-3206 ; 0000-0001-5906-1543 ; 0000-0002-2003-6567</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874124014326$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39571699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haikal, Abdullah</creatorcontrib><creatorcontrib>El-Neketi, Mona</creatorcontrib><creatorcontrib>Helal, Manar G.</creatorcontrib><creatorcontrib>Abou-zeid, Laila A.</creatorcontrib><creatorcontrib>Hassan, Madiha A.</creatorcontrib><creatorcontrib>Gohar, Ahmed A.</creatorcontrib><title>Anti-asthmatic and antioxidant activity of flavonoids isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on ovalbumin-induced allergic asthma in mice: In-vivo and in-silico study</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Mentha longifolia L. has been employed to treat cough, lung inflammation, and bronchial asthma disorders.
Our study was carried out to investigate the medicinal effect of the flavonoids derived from M. longifolia, specifically didymin, linarin, rutin, and TMF, as well as the whole extracts of M. longifolia subsp. typhoides and M. longifolia subsp. schimperi, in comparison to dexa, in a mice model of ovalbumin-allergic asthma (OVA).
After inhaling OVA, the mice developed acute asthma symptoms. Mice were subjected orally to Dexa and/or isolated flavonoids. The study assessed total and differential leukocyte counts, LDH concentration, and total protein concentration in BALF, reduced levels of GSH and total NOx products in lung tissues and analyzed the lung specimens by staining them with hematoxylin and eosin (H & E).
Histopathological analysis of the right lung lobes demonstrated that the isolated flavonoids exhibited a significant anti-inflammatory effect higher than Dexa as shown by decreasing the overall and distinct leukocyte counts, LDH levels, and total protein levels in BALF, as compared to the OVA group (p < 0.05). TMF was the most effective and the other tested flavonoids are more effective than Dexa but less than TMF. In addition, all tested flavonoids and Dexa significantly (p < 0.05) mitigated OVA-induced oxidative stress as evidenced by diminished lung NOx level and elevated GSH level. Computational docking studies proved recognition of didymin, linarin, rutin, and TMF to the human leukocyte elastase binding sites.
The tested flavonoids; didymin, linarin, rutin, and TMF successfully inhibit Ova-induced allergic asthma in mice through their anti-inflammatory and antioxidant activities and may represent promising candidate as a remedy for allergic asthma.
[Display omitted]
•Exploring the anti-asthma activity of the methanol extract of Mentha longifolia on ovalbumin-induced allergic asthma in mice, together with some pure flavonoids (didymin, linarin, rutin and tetramethoxyflavone).•Clarifying the mechanism of anti-ashmatic activity; significant reduction of differential leukocytic count, total protein content, and LDH activity in BALF, increase in GSH concentration, and decrease in NOx concentration.•Histopathological examination of the lung tissues under the effect of OVA and suggested drugs.•In-silico study to correlate the active substances protein-binding affinity to the results of the in vivo study.</description><subject>Animals</subject><subject>Anti-Asthmatic Agents - isolation & purification</subject><subject>Anti-Asthmatic Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Asthma - chemically induced</subject><subject>Asthma - drug therapy</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Didymin</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - pharmacology</subject><subject>Linarin</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>M. longifolia</subject><subject>Male</subject><subject>Mentha - chemistry</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Docking Simulation</subject><subject>Ovalbumin</subject><subject>Ovalbumin allergic asthma</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Rutin</subject><subject>Tetramethoxyflavone</subject><issn>0378-8741</issn><issn>1872-7573</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAUjBCILoUfwAX5WA4JtvNhB06lAlqpiAucLcd2um_l2KntRN0fj4R3t_TYgzU-zMx786Yo3hNcEUy6T7tqZ-aKYtpUhPSkrl8UG8IZLVnL6pfFBteMl5w15Kx4E-MOY8xIg18XZ3XfMtL1_ab4e-kSlDKm7SQTKCSdzi-BfwCdEUmVYIW0R35Eo5Wrdx50RBC9lcloNAY_oZ_Gpa1E1rs7GL0FieIyxNkoMBGl_bzNmvy7-BrgvvqIrmWwZl8dZz0rjWoL02wCPEmPgLxDfpV2WCZwJTi9qLyJtNaEu0OEYxgEDk2gzGd048oVVn8cl_kRLCiPYlr0_m3xapQ2mnePeF78-f7t99V1efvrx83V5W2paN2mUne4lRj3dFCKSoZ7PNSE8473nErayM5wItWgKWnazkiuG8Wl4R2tx643DNfnxcXJdw7-fjExiQmiMtZKZ_wSRU2yX0sYo5lKTlQVfIzBjGIOMMmwFwSLQ-tiJ3Lr4tC6OLWeNR8e7ZdhMvpJ8b_mTPhyIpgccgUTRMwHdvlsEIxKQnt4xv4f4mnCgQ</recordid><startdate>20250113</startdate><enddate>20250113</enddate><creator>Haikal, Abdullah</creator><creator>El-Neketi, Mona</creator><creator>Helal, Manar G.</creator><creator>Abou-zeid, Laila A.</creator><creator>Hassan, Madiha A.</creator><creator>Gohar, Ahmed A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2608-3206</orcidid><orcidid>https://orcid.org/0000-0001-5906-1543</orcidid><orcidid>https://orcid.org/0000-0002-2003-6567</orcidid></search><sort><creationdate>20250113</creationdate><title>Anti-asthmatic and antioxidant activity of flavonoids isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on ovalbumin-induced allergic asthma in mice: In-vivo and in-silico study</title><author>Haikal, Abdullah ; El-Neketi, Mona ; Helal, Manar G. ; Abou-zeid, Laila A. ; Hassan, Madiha A. ; Gohar, Ahmed A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c235t-d605a0092bcc2a7090b318868982a24a6e81acbd21456ea8d4c8ae8623f69e703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Animals</topic><topic>Anti-Asthmatic Agents - isolation & purification</topic><topic>Anti-Asthmatic Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Asthma - chemically induced</topic><topic>Asthma - drug therapy</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Didymin</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Flavonoids - isolation & purification</topic><topic>Flavonoids - pharmacology</topic><topic>Linarin</topic><topic>Lung - drug effects</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>M. longifolia</topic><topic>Male</topic><topic>Mentha - chemistry</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Docking Simulation</topic><topic>Ovalbumin</topic><topic>Ovalbumin allergic asthma</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Rutin</topic><topic>Tetramethoxyflavone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haikal, Abdullah</creatorcontrib><creatorcontrib>El-Neketi, Mona</creatorcontrib><creatorcontrib>Helal, Manar G.</creatorcontrib><creatorcontrib>Abou-zeid, Laila A.</creatorcontrib><creatorcontrib>Hassan, Madiha A.</creatorcontrib><creatorcontrib>Gohar, Ahmed A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haikal, Abdullah</au><au>El-Neketi, Mona</au><au>Helal, Manar G.</au><au>Abou-zeid, Laila A.</au><au>Hassan, Madiha A.</au><au>Gohar, Ahmed A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-asthmatic and antioxidant activity of flavonoids isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on ovalbumin-induced allergic asthma in mice: In-vivo and in-silico study</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2025-01-13</date><risdate>2025</risdate><volume>339</volume><spage>119133</spage><pages>119133-</pages><artnum>119133</artnum><issn>0378-8741</issn><issn>1872-7573</issn><eissn>1872-7573</eissn><abstract>Mentha longifolia L. has been employed to treat cough, lung inflammation, and bronchial asthma disorders.
Our study was carried out to investigate the medicinal effect of the flavonoids derived from M. longifolia, specifically didymin, linarin, rutin, and TMF, as well as the whole extracts of M. longifolia subsp. typhoides and M. longifolia subsp. schimperi, in comparison to dexa, in a mice model of ovalbumin-allergic asthma (OVA).
After inhaling OVA, the mice developed acute asthma symptoms. Mice were subjected orally to Dexa and/or isolated flavonoids. The study assessed total and differential leukocyte counts, LDH concentration, and total protein concentration in BALF, reduced levels of GSH and total NOx products in lung tissues and analyzed the lung specimens by staining them with hematoxylin and eosin (H & E).
Histopathological analysis of the right lung lobes demonstrated that the isolated flavonoids exhibited a significant anti-inflammatory effect higher than Dexa as shown by decreasing the overall and distinct leukocyte counts, LDH levels, and total protein levels in BALF, as compared to the OVA group (p < 0.05). TMF was the most effective and the other tested flavonoids are more effective than Dexa but less than TMF. In addition, all tested flavonoids and Dexa significantly (p < 0.05) mitigated OVA-induced oxidative stress as evidenced by diminished lung NOx level and elevated GSH level. Computational docking studies proved recognition of didymin, linarin, rutin, and TMF to the human leukocyte elastase binding sites.
The tested flavonoids; didymin, linarin, rutin, and TMF successfully inhibit Ova-induced allergic asthma in mice through their anti-inflammatory and antioxidant activities and may represent promising candidate as a remedy for allergic asthma.
[Display omitted]
•Exploring the anti-asthma activity of the methanol extract of Mentha longifolia on ovalbumin-induced allergic asthma in mice, together with some pure flavonoids (didymin, linarin, rutin and tetramethoxyflavone).•Clarifying the mechanism of anti-ashmatic activity; significant reduction of differential leukocytic count, total protein content, and LDH activity in BALF, increase in GSH concentration, and decrease in NOx concentration.•Histopathological examination of the lung tissues under the effect of OVA and suggested drugs.•In-silico study to correlate the active substances protein-binding affinity to the results of the in vivo study.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>39571699</pmid><doi>10.1016/j.jep.2024.119133</doi><orcidid>https://orcid.org/0000-0003-2608-3206</orcidid><orcidid>https://orcid.org/0000-0001-5906-1543</orcidid><orcidid>https://orcid.org/0000-0002-2003-6567</orcidid></addata></record> |
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| subjects | Animals Anti-Asthmatic Agents - isolation & purification Anti-Asthmatic Agents - pharmacology Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Antioxidants - isolation & purification Antioxidants - pharmacology Asthma - chemically induced Asthma - drug therapy Bronchoalveolar Lavage Fluid Didymin Disease Models, Animal Female Flavonoids - isolation & purification Flavonoids - pharmacology Linarin Lung - drug effects Lung - metabolism Lung - pathology M. longifolia Male Mentha - chemistry Mice Mice, Inbred BALB C Molecular Docking Simulation Ovalbumin Ovalbumin allergic asthma Plant Extracts - chemistry Plant Extracts - pharmacology Rutin Tetramethoxyflavone |
| title | Anti-asthmatic and antioxidant activity of flavonoids isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on ovalbumin-induced allergic asthma in mice: In-vivo and in-silico study |
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