99mTc-Labeled D‑Type PTP as a Plectin-Targeting Single-Photon Emission Computed Tomography Probe for Hepatocellular Carcinoma Imaging

Plectin, a scaffolding protein overexpressed in tumor cells, plays a significant role in hepatocellular carcinoma (HCC) proliferation, invasion, and migration. However, the use of L-type peptides for targeting plectin is hindered by their limited stability and retention. We designed a D-type plectin...

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Veröffentlicht in:Bioconjugate chemistry 2024-12, Vol.35 (12), p.1997-2005
Hauptverfasser: Gong, JiaLi, Zhu, Meilin, Zhao, Lingzhou, Wang, Taisong, Qiao, Wenli, Huang, Qingqing, Xing, Yan, Zhao, Jinhua
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Sprache:eng
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