The crucial role of risk factors when dealing with hepatic Encephalopathy
Hepatic encephalopathy (HE) is a common condition in patients with cirrhosis, representing the second most frequent cause of decompensation. Approximately 30–40% of patients with cirrhosis will experience overt HE during the clinical course of their illness. In most cases, it is possible to identify...
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| creator | Lapenna, Lucia Di Cola, Simone Merli, Manuela |
| description | Hepatic encephalopathy (HE) is a common condition in patients with cirrhosis, representing the second most frequent cause of decompensation. Approximately 30–40% of patients with cirrhosis will experience overt HE during the clinical course of their illness. In most cases, it is possible to identify a precipitating or risk factor for HE. These are distinct concepts that play different roles in the development of this condition. While precipitating factors act acutely, risk factors are generally present over an extended period and contribute to the overall likelihood of developing HE. The two types of factors require different approaches, with risk factors being more susceptible to prevention. The aim of this review is to describe the most important risk factors (such as severity of liver disease, previous episode of HE, minimal/covert HE, spontaneous and iatrogenic shunt, malnutrition, chronic therapies, metabolic diseases) for the development of HE and how to prevent it. |
| doi_str_mv | 10.1007/s11011-024-01446-0 |
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Di Cola, Simone ; Merli, Manuela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-6533a8965a3b8768d93c1ba2acf2f0c33cf5f3c9990d8feab84c6cbf39945f7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain diseases</topic><topic>Cirrhosis</topic><topic>Hepatic Encephalopathy</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver diseases</topic><topic>Liver transplants</topic><topic>Malnutrition</topic><topic>Malnutrition - complications</topic><topic>Metabolic Diseases</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prevention</topic><topic>Quality of life</topic><topic>Quantitative psychology</topic><topic>Review</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lapenna, Lucia</creatorcontrib><creatorcontrib>Di Cola, Simone</creatorcontrib><creatorcontrib>Merli, Manuela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolic brain disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lapenna, Lucia</au><au>Di Cola, Simone</au><au>Merli, Manuela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The crucial role of risk factors when dealing with hepatic Encephalopathy</atitle><jtitle>Metabolic brain disease</jtitle><stitle>Metab Brain Dis</stitle><addtitle>Metab Brain Dis</addtitle><date>2024-11-21</date><risdate>2024</risdate><volume>40</volume><issue>1</issue><spage>29</spage><pages>29-</pages><artnum>29</artnum><issn>1573-7365</issn><issn>0885-7490</issn><eissn>1573-7365</eissn><abstract>Hepatic encephalopathy (HE) is a common condition in patients with cirrhosis, representing the second most frequent cause of decompensation. Approximately 30–40% of patients with cirrhosis will experience overt HE during the clinical course of their illness. In most cases, it is possible to identify a precipitating or risk factor for HE. These are distinct concepts that play different roles in the development of this condition. While precipitating factors act acutely, risk factors are generally present over an extended period and contribute to the overall likelihood of developing HE. The two types of factors require different approaches, with risk factors being more susceptible to prevention. The aim of this review is to describe the most important risk factors (such as severity of liver disease, previous episode of HE, minimal/covert HE, spontaneous and iatrogenic shunt, malnutrition, chronic therapies, metabolic diseases) for the development of HE and how to prevent it.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39570425</pmid><doi>10.1007/s11011-024-01446-0</doi></addata></record> |
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| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Brain diseases Cirrhosis Hepatic Encephalopathy Hospitalization Humans Liver cirrhosis Liver Cirrhosis - complications Liver diseases Liver transplants Malnutrition Malnutrition - complications Metabolic Diseases Metabolic disorders Metabolism Mortality Neurology Neurosciences Oncology Patients Prevention Quality of life Quantitative psychology Review Risk Factors |
| title | The crucial role of risk factors when dealing with hepatic Encephalopathy |
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