Discovery of GS-2278, a Potent and Selective LPAR1 Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis

We describe the discovery and preclinical characterization of a potent and selective lysophosphatidic acid receptor 1 (LPAR1) antagonist with a direct-acting antifibrotic mechanism. was initially identified as a potent non-carboxylic acid LPAR1 antagonist in an LPA-induced myocardin-related transcri...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2024-11
Hauptverfasser:	Tang, Doris T, Du, Zhimin, Yang, Kin S, Bestvater, Brian P, Kaplan, Joshua, Neubig, Megan E, Olen, Casey L, Phillips, Bart, Wang, Peiyuan, Hudson, Thomas, Marchand, Bruno, Chan, Julie, Sharma, Monika, Hu, Yiding, Matles, Mike, Nejati, Elham, Chojnacka, Maja, Adams, Clifton, Pong, Cassie, Holsapple, Kevin, Budas, Grant, Tsui, Vickie, Venkataramani, Chandrasekar, Lazerwith, Scott E, Notte, Gregory T, Watkins, William J, McGlinchey, Ellen, Zagorska, Anna, Farand, Julie
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!