Proteomic analysis identifies novel biological pathways that may link dietary quality to type 2 diabetes risk: evidence from African American and Asian cohorts
Diet affects the development of chronic diseases such as type 2 diabetes, but the underlying biological mechanisms are only partly understood. This study aimed to identify proteomic markers of the Alternative Healthy Eating Index (AHEI) and the Dietary Approaches to Stop Hypertension (DASH) diet and...
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| Veröffentlicht in: | The American journal of clinical nutrition 2024-11 |
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| creator | Lim, Charlie GY Gradinariu, Vlad Liang, Yujian Rebholz, Casey M Talegawkar, Sameera Temprosa, Marinella Min, Yuan-I Sim, Xueling Wilson, James G van Dam, Rob M |
| description | Diet affects the development of chronic diseases such as type 2 diabetes, but the underlying biological mechanisms are only partly understood.
This study aimed to identify proteomic markers of the Alternative Healthy Eating Index (AHEI) and the Dietary Approaches to Stop Hypertension (DASH) diet and their association with type 2 diabetes risk.
We examined the associations between the AHEI and DASH diet quality scores and 1317 plasma proteins in African American participants of the Jackson Heart Study (JHS, n = 1878). These findings were validated in a Singapore Multi-Ethnic Cohort (n = 2395) and examined in relation to type 2 diabetes incidence (n = 539 cases). We adjusted for multiple testing by using false discovery rate–adjusted q values.
We identified 13 proteins consistently associated with the AHEI or DASH scores with the strongest associations for the AHEI score and epidermal growth factor receptor (β:0.089; SE: 0.017; q < 0.001) and for the DASH score and tissue factor (β: −0.114; SE: 0.022; q < 0.001). Most of these proteins were related to inflammation, thrombosis, adipogenesis, and glucose metabolism. Concentrations of myeloperoxidase, epidermal growth factor receptor, hepatocyte growth factor receptor, coagulation factor Xa, contactin 4, kynureninase, neurogenic locus notch homolog protein 1, and vesicular integral-membrane protein VIP36 were associated with the risk of type 2 diabetes in the Asian cohort. The diabetes odds ratio for a 2-fold higher protein abundance concentration ranged from 0.03 (95% CI: 0.01, 0.08) for neurogenic locus notch homolog protein 1 to 3.04 (95% CI: 2.13, 4.33) for kynureninase. Furthermore, genetic markers for myeloperoxidase and hepatocyte growth factor receptor were significantly associated with diabetes risk.
Our study across geographically and ethnically diverse populations identified robust protein biomarkers for healthy dietary patterns. Furthermore, our findings suggest novel biological mechanisms linking dietary patterns with type 2 diabetes development. |
| doi_str_mv | 10.1016/j.ajcnut.2024.11.016 |
| format | Article |
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This study aimed to identify proteomic markers of the Alternative Healthy Eating Index (AHEI) and the Dietary Approaches to Stop Hypertension (DASH) diet and their association with type 2 diabetes risk.
We examined the associations between the AHEI and DASH diet quality scores and 1317 plasma proteins in African American participants of the Jackson Heart Study (JHS, n = 1878). These findings were validated in a Singapore Multi-Ethnic Cohort (n = 2395) and examined in relation to type 2 diabetes incidence (n = 539 cases). We adjusted for multiple testing by using false discovery rate–adjusted q values.
We identified 13 proteins consistently associated with the AHEI or DASH scores with the strongest associations for the AHEI score and epidermal growth factor receptor (β:0.089; SE: 0.017; q < 0.001) and for the DASH score and tissue factor (β: −0.114; SE: 0.022; q < 0.001). Most of these proteins were related to inflammation, thrombosis, adipogenesis, and glucose metabolism. Concentrations of myeloperoxidase, epidermal growth factor receptor, hepatocyte growth factor receptor, coagulation factor Xa, contactin 4, kynureninase, neurogenic locus notch homolog protein 1, and vesicular integral-membrane protein VIP36 were associated with the risk of type 2 diabetes in the Asian cohort. The diabetes odds ratio for a 2-fold higher protein abundance concentration ranged from 0.03 (95% CI: 0.01, 0.08) for neurogenic locus notch homolog protein 1 to 3.04 (95% CI: 2.13, 4.33) for kynureninase. Furthermore, genetic markers for myeloperoxidase and hepatocyte growth factor receptor were significantly associated with diabetes risk.
Our study across geographically and ethnically diverse populations identified robust protein biomarkers for healthy dietary patterns. Furthermore, our findings suggest novel biological mechanisms linking dietary patterns with type 2 diabetes development.</description><identifier>ISSN: 0002-9165</identifier><identifier>ISSN: 1938-3207</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1016/j.ajcnut.2024.11.016</identifier><identifier>PMID: 39566683</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alternative Healthy Eating Index ; Dietary Approaches to Stop Hypertension ; dietary patterns ; proteomics ; SomaScan ; type 2 diabetes</subject><ispartof>The American journal of clinical nutrition, 2024-11</ispartof><rights>2024 American Society for Nutrition</rights><rights>Copyright © 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1563-ea6467426e622b7518f3ddbaa5ad1332af66a729a1acf03833b1d3b89b81d65f3</cites><orcidid>0000-0002-6709-8722 ; 0000-0002-7354-8734</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39566683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Charlie GY</creatorcontrib><creatorcontrib>Gradinariu, Vlad</creatorcontrib><creatorcontrib>Liang, Yujian</creatorcontrib><creatorcontrib>Rebholz, Casey M</creatorcontrib><creatorcontrib>Talegawkar, Sameera</creatorcontrib><creatorcontrib>Temprosa, Marinella</creatorcontrib><creatorcontrib>Min, Yuan-I</creatorcontrib><creatorcontrib>Sim, Xueling</creatorcontrib><creatorcontrib>Wilson, James G</creatorcontrib><creatorcontrib>van Dam, Rob M</creatorcontrib><title>Proteomic analysis identifies novel biological pathways that may link dietary quality to type 2 diabetes risk: evidence from African American and Asian cohorts</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Diet affects the development of chronic diseases such as type 2 diabetes, but the underlying biological mechanisms are only partly understood.
This study aimed to identify proteomic markers of the Alternative Healthy Eating Index (AHEI) and the Dietary Approaches to Stop Hypertension (DASH) diet and their association with type 2 diabetes risk.
We examined the associations between the AHEI and DASH diet quality scores and 1317 plasma proteins in African American participants of the Jackson Heart Study (JHS, n = 1878). These findings were validated in a Singapore Multi-Ethnic Cohort (n = 2395) and examined in relation to type 2 diabetes incidence (n = 539 cases). We adjusted for multiple testing by using false discovery rate–adjusted q values.
We identified 13 proteins consistently associated with the AHEI or DASH scores with the strongest associations for the AHEI score and epidermal growth factor receptor (β:0.089; SE: 0.017; q < 0.001) and for the DASH score and tissue factor (β: −0.114; SE: 0.022; q < 0.001). Most of these proteins were related to inflammation, thrombosis, adipogenesis, and glucose metabolism. Concentrations of myeloperoxidase, epidermal growth factor receptor, hepatocyte growth factor receptor, coagulation factor Xa, contactin 4, kynureninase, neurogenic locus notch homolog protein 1, and vesicular integral-membrane protein VIP36 were associated with the risk of type 2 diabetes in the Asian cohort. The diabetes odds ratio for a 2-fold higher protein abundance concentration ranged from 0.03 (95% CI: 0.01, 0.08) for neurogenic locus notch homolog protein 1 to 3.04 (95% CI: 2.13, 4.33) for kynureninase. Furthermore, genetic markers for myeloperoxidase and hepatocyte growth factor receptor were significantly associated with diabetes risk.
Our study across geographically and ethnically diverse populations identified robust protein biomarkers for healthy dietary patterns. Furthermore, our findings suggest novel biological mechanisms linking dietary patterns with type 2 diabetes development.</description><subject>Alternative Healthy Eating Index</subject><subject>Dietary Approaches to Stop Hypertension</subject><subject>dietary patterns</subject><subject>proteomics</subject><subject>SomaScan</subject><subject>type 2 diabetes</subject><issn>0002-9165</issn><issn>1938-3207</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9UcuO1DAQjBCIHRb-ACEfuSS47cST4YA0WvGSVoIDnK2O3WE8m8SztjOrfA2_ikdZOHLqUnd1tbqqKF4Dr4CDenes8GimOVWCi7oCqHLzSbGBnWxLKfj2abHhnItyB6q5Kl7EeOQcRN2q58WV3DVKqVZuit_fg0_kR2cYTjgs0UXmLE3J9Y4im_yZBtY5P_hfzuDATpgOD7hElg6Y2IgLG9x0x6yjhGFh9zMOLi0seZaWEzGRJ9hRylLBxbv3jM4XdUOsD35k-z5k1YntR1oBTpbto8vI-IMPKb4snvU4RHr1WK-Ln58-_rj5Ut5--_z1Zn9bGmiULAlVrba1UKSE6LYNtL20tkNs0IKUAnulcCt2CGh6LlspO7Cya3ddC1Y1vbwu3q66p-DvZ4pJjy4aGgacyM9RS5DQZDsVZGq9Uk3wMQbq9Sm4MX-vgetLNPqo12j0JRoNoHMzr715vDB3I9l_S3-zyIQPK4Hyn2dHQUfjLl5ZF8gkbb37_4U_zhCkrg</recordid><startdate>20241119</startdate><enddate>20241119</enddate><creator>Lim, Charlie GY</creator><creator>Gradinariu, Vlad</creator><creator>Liang, Yujian</creator><creator>Rebholz, Casey M</creator><creator>Talegawkar, Sameera</creator><creator>Temprosa, Marinella</creator><creator>Min, Yuan-I</creator><creator>Sim, Xueling</creator><creator>Wilson, James G</creator><creator>van Dam, Rob M</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6709-8722</orcidid><orcidid>https://orcid.org/0000-0002-7354-8734</orcidid></search><sort><creationdate>20241119</creationdate><title>Proteomic analysis identifies novel biological pathways that may link dietary quality to type 2 diabetes risk: evidence from African American and Asian cohorts</title><author>Lim, Charlie GY ; Gradinariu, Vlad ; Liang, Yujian ; Rebholz, Casey M ; Talegawkar, Sameera ; Temprosa, Marinella ; Min, Yuan-I ; Sim, Xueling ; Wilson, James G ; van Dam, Rob M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1563-ea6467426e622b7518f3ddbaa5ad1332af66a729a1acf03833b1d3b89b81d65f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alternative Healthy Eating Index</topic><topic>Dietary Approaches to Stop Hypertension</topic><topic>dietary patterns</topic><topic>proteomics</topic><topic>SomaScan</topic><topic>type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Charlie GY</creatorcontrib><creatorcontrib>Gradinariu, Vlad</creatorcontrib><creatorcontrib>Liang, Yujian</creatorcontrib><creatorcontrib>Rebholz, Casey M</creatorcontrib><creatorcontrib>Talegawkar, Sameera</creatorcontrib><creatorcontrib>Temprosa, Marinella</creatorcontrib><creatorcontrib>Min, Yuan-I</creatorcontrib><creatorcontrib>Sim, Xueling</creatorcontrib><creatorcontrib>Wilson, James G</creatorcontrib><creatorcontrib>van Dam, Rob M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Charlie GY</au><au>Gradinariu, Vlad</au><au>Liang, Yujian</au><au>Rebholz, Casey M</au><au>Talegawkar, Sameera</au><au>Temprosa, Marinella</au><au>Min, Yuan-I</au><au>Sim, Xueling</au><au>Wilson, James G</au><au>van Dam, Rob M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proteomic analysis identifies novel biological pathways that may link dietary quality to type 2 diabetes risk: evidence from African American and Asian cohorts</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2024-11-19</date><risdate>2024</risdate><issn>0002-9165</issn><issn>1938-3207</issn><eissn>1938-3207</eissn><abstract>Diet affects the development of chronic diseases such as type 2 diabetes, but the underlying biological mechanisms are only partly understood.
This study aimed to identify proteomic markers of the Alternative Healthy Eating Index (AHEI) and the Dietary Approaches to Stop Hypertension (DASH) diet and their association with type 2 diabetes risk.
We examined the associations between the AHEI and DASH diet quality scores and 1317 plasma proteins in African American participants of the Jackson Heart Study (JHS, n = 1878). These findings were validated in a Singapore Multi-Ethnic Cohort (n = 2395) and examined in relation to type 2 diabetes incidence (n = 539 cases). We adjusted for multiple testing by using false discovery rate–adjusted q values.
We identified 13 proteins consistently associated with the AHEI or DASH scores with the strongest associations for the AHEI score and epidermal growth factor receptor (β:0.089; SE: 0.017; q < 0.001) and for the DASH score and tissue factor (β: −0.114; SE: 0.022; q < 0.001). Most of these proteins were related to inflammation, thrombosis, adipogenesis, and glucose metabolism. Concentrations of myeloperoxidase, epidermal growth factor receptor, hepatocyte growth factor receptor, coagulation factor Xa, contactin 4, kynureninase, neurogenic locus notch homolog protein 1, and vesicular integral-membrane protein VIP36 were associated with the risk of type 2 diabetes in the Asian cohort. The diabetes odds ratio for a 2-fold higher protein abundance concentration ranged from 0.03 (95% CI: 0.01, 0.08) for neurogenic locus notch homolog protein 1 to 3.04 (95% CI: 2.13, 4.33) for kynureninase. Furthermore, genetic markers for myeloperoxidase and hepatocyte growth factor receptor were significantly associated with diabetes risk.
Our study across geographically and ethnically diverse populations identified robust protein biomarkers for healthy dietary patterns. Furthermore, our findings suggest novel biological mechanisms linking dietary patterns with type 2 diabetes development.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39566683</pmid><doi>10.1016/j.ajcnut.2024.11.016</doi><orcidid>https://orcid.org/0000-0002-6709-8722</orcidid><orcidid>https://orcid.org/0000-0002-7354-8734</orcidid></addata></record> |
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| subjects | Alternative Healthy Eating Index Dietary Approaches to Stop Hypertension dietary patterns proteomics SomaScan type 2 diabetes |
| title | Proteomic analysis identifies novel biological pathways that may link dietary quality to type 2 diabetes risk: evidence from African American and Asian cohorts |
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