Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling

The enzymatic oxidation of arachidonic acid is proposed to yield trihydroxytetraene species (termed lipoxins) that resolve inflammation via ligand activation of the formyl peptide receptor, FPR2. While cell and murine models activate signaling responses to synthetic lipoxins, primarily lipoxin A4 (L...

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Veröffentlicht in:	Journal of lipid research 2024-11, p.100705, Article 100705
Hauptverfasser:	Koudelka, Adolf, Buchan, Gregory J., Cechova, Veronika, O’Brien, James P., Stevenson, Emily R., Uvalle, Crystal E., Liu, Heng, Woodcock, Steven R., Mullett, Steven J., Zhang, Cheng, Freeman, Bruce A., Gelhaus, Stacy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	arachidonic acid electrophile formyl peptide receptor Inflammation resolution lipoxin lipoxygenase
Online-Zugang:	Volltext
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