Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery

Bacterial infections in humans and animals caused by multidrug-resistant (MDR) pathogens pose a serious threat to public health. New antibacterial targets are extremely urgent to solve the dilemma of cross-resistance. Phospholipids are critical components in bacterial envelopes and involve diverse c...

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Veröffentlicht in:	Progress in lipid research 2024-11, Vol.96, p.101307, Article 101307
Hauptverfasser:	Song, Meirong, Chen, Shang, Lin, Wenhan, Zhu, Kui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial target Bacteria - drug effects Bacteria - metabolism Bacterial Infections - drug therapy Bacterial Infections - metabolism Bacterial Infections - microbiology Drug Discovery Humans Membrane Phospholipid Phospholipid biosynthesis Phospholipid ligands Phospholipids - chemistry Phospholipids - metabolism Structure-Activity Relationship
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