Social state alters vision using three circuit mechanisms in Drosophila

Animals are often bombarded with visual information and must prioritize specific visual features based on their current needs. The neuronal circuits that detect and relay visual features have been well studied . Much less is known about how an animal adjusts its visual attention as its goals or envi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 2024-11
Hauptverfasser: Schretter, Catherine E, Hindmarsh Sten, Tom, Klapoetke, Nathan, Shao, Mei, Nern, Aljoscha, Dreher, Marisa, Bushey, Daniel, Robie, Alice A, Taylor, Adam L, Branson, Kristin, Otopalik, Adriane, Ruta, Vanessa, Rubin, Gerald M
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title Nature (London)
container_volume
creator Schretter, Catherine E
Hindmarsh Sten, Tom
Klapoetke, Nathan
Shao, Mei
Nern, Aljoscha
Dreher, Marisa
Bushey, Daniel
Robie, Alice A
Taylor, Adam L
Branson, Kristin
Otopalik, Adriane
Ruta, Vanessa
Rubin, Gerald M
description Animals are often bombarded with visual information and must prioritize specific visual features based on their current needs. The neuronal circuits that detect and relay visual features have been well studied . Much less is known about how an animal adjusts its visual attention as its goals or environmental conditions change. During social behaviours, flies need to focus on nearby flies . Here we study how the flow of visual information is altered when female Drosophila enter an aggressive state. From the connectome, we identify three state-dependent circuit motifs poised to modify the response of an aggressive female to fly-sized visual objects: convergence of excitatory inputs from neurons conveying select visual features and internal state; dendritic disinhibition of select visual feature detectors; and a switch that toggles between two visual feature detectors. Using cell-type-specific genetic tools, together with behavioural and neurophysiological analyses, we show that each of these circuit motifs is used during female aggression. We reveal that features of this same switch operate in male Drosophila during courtship pursuit, suggesting that disparate social behaviours may share circuit mechanisms. Our study provides a compelling example of using the connectome to infer circuit mechanisms that underlie dynamic processing of sensory signals.
doi_str_mv 10.1038/s41586-024-08255-6
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3131498263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3131498263</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-ccee7edecea49c32d0669fcb798b8741957b4c20158df38c71e98c6c3bffb8e23</originalsourceid><addsrcrecordid>eNo9kDtPw0AQhE8IRELgD1CgK2kM9_I9ShQgIEWiAOrTeb0mh_wIPhuJf48hgWqKnRntfIScc3bFmbTXSfHc6owJlTEr8jzTB2TOldGZ0tYckjljwk4nqWfkJKV3xljOjTomM-lybbRzc7J67iCGmqYhDEhDPWCf6GdMsWvpmGL7RodNj0gh9jDGgTYIm9DG1CQaW3rbd6nbbmIdTslRFeqEZ3tdkNf7u5flQ7Z-Wj0ub9YZCGGHDADRYImAQTmQomRauwoK42xhjeIuN4UCwaZhZSUtGI7OggZZVFVhUcgFudz1bvvuY8Q0-CYmwLoOLXZj8pJLrpwVWk5WsbPC9GXqsfLbPjah__Kc-R-AfgfQTwD9L0Cvp9DFvn8sGiz_I3_E5Deuw2zy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3131498263</pqid></control><display><type>article</type><title>Social state alters vision using three circuit mechanisms in Drosophila</title><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Schretter, Catherine E ; Hindmarsh Sten, Tom ; Klapoetke, Nathan ; Shao, Mei ; Nern, Aljoscha ; Dreher, Marisa ; Bushey, Daniel ; Robie, Alice A ; Taylor, Adam L ; Branson, Kristin ; Otopalik, Adriane ; Ruta, Vanessa ; Rubin, Gerald M</creator><creatorcontrib>Schretter, Catherine E ; Hindmarsh Sten, Tom ; Klapoetke, Nathan ; Shao, Mei ; Nern, Aljoscha ; Dreher, Marisa ; Bushey, Daniel ; Robie, Alice A ; Taylor, Adam L ; Branson, Kristin ; Otopalik, Adriane ; Ruta, Vanessa ; Rubin, Gerald M</creatorcontrib><description>Animals are often bombarded with visual information and must prioritize specific visual features based on their current needs. The neuronal circuits that detect and relay visual features have been well studied . Much less is known about how an animal adjusts its visual attention as its goals or environmental conditions change. During social behaviours, flies need to focus on nearby flies . Here we study how the flow of visual information is altered when female Drosophila enter an aggressive state. From the connectome, we identify three state-dependent circuit motifs poised to modify the response of an aggressive female to fly-sized visual objects: convergence of excitatory inputs from neurons conveying select visual features and internal state; dendritic disinhibition of select visual feature detectors; and a switch that toggles between two visual feature detectors. Using cell-type-specific genetic tools, together with behavioural and neurophysiological analyses, we show that each of these circuit motifs is used during female aggression. We reveal that features of this same switch operate in male Drosophila during courtship pursuit, suggesting that disparate social behaviours may share circuit mechanisms. Our study provides a compelling example of using the connectome to infer circuit mechanisms that underlie dynamic processing of sensory signals.</description><identifier>ISSN: 0028-0836</identifier><identifier>ISSN: 1476-4687</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/s41586-024-08255-6</identifier><identifier>PMID: 39567699</identifier><language>eng</language><publisher>England</publisher><ispartof>Nature (London), 2024-11</ispartof><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-ccee7edecea49c32d0669fcb798b8741957b4c20158df38c71e98c6c3bffb8e23</cites><orcidid>0000-0002-0784-2927 ; 0000-0002-4963-2768 ; 0000-0002-3957-6838 ; 0000-0001-8762-8703 ; 0000-0002-5567-2512 ; 0000-0001-6581-1603 ; 0000-0002-3822-489X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39567699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schretter, Catherine E</creatorcontrib><creatorcontrib>Hindmarsh Sten, Tom</creatorcontrib><creatorcontrib>Klapoetke, Nathan</creatorcontrib><creatorcontrib>Shao, Mei</creatorcontrib><creatorcontrib>Nern, Aljoscha</creatorcontrib><creatorcontrib>Dreher, Marisa</creatorcontrib><creatorcontrib>Bushey, Daniel</creatorcontrib><creatorcontrib>Robie, Alice A</creatorcontrib><creatorcontrib>Taylor, Adam L</creatorcontrib><creatorcontrib>Branson, Kristin</creatorcontrib><creatorcontrib>Otopalik, Adriane</creatorcontrib><creatorcontrib>Ruta, Vanessa</creatorcontrib><creatorcontrib>Rubin, Gerald M</creatorcontrib><title>Social state alters vision using three circuit mechanisms in Drosophila</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>Animals are often bombarded with visual information and must prioritize specific visual features based on their current needs. The neuronal circuits that detect and relay visual features have been well studied . Much less is known about how an animal adjusts its visual attention as its goals or environmental conditions change. During social behaviours, flies need to focus on nearby flies . Here we study how the flow of visual information is altered when female Drosophila enter an aggressive state. From the connectome, we identify three state-dependent circuit motifs poised to modify the response of an aggressive female to fly-sized visual objects: convergence of excitatory inputs from neurons conveying select visual features and internal state; dendritic disinhibition of select visual feature detectors; and a switch that toggles between two visual feature detectors. Using cell-type-specific genetic tools, together with behavioural and neurophysiological analyses, we show that each of these circuit motifs is used during female aggression. We reveal that features of this same switch operate in male Drosophila during courtship pursuit, suggesting that disparate social behaviours may share circuit mechanisms. Our study provides a compelling example of using the connectome to infer circuit mechanisms that underlie dynamic processing of sensory signals.</description><issn>0028-0836</issn><issn>1476-4687</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kDtPw0AQhE8IRELgD1CgK2kM9_I9ShQgIEWiAOrTeb0mh_wIPhuJf48hgWqKnRntfIScc3bFmbTXSfHc6owJlTEr8jzTB2TOldGZ0tYckjljwk4nqWfkJKV3xljOjTomM-lybbRzc7J67iCGmqYhDEhDPWCf6GdMsWvpmGL7RodNj0gh9jDGgTYIm9DG1CQaW3rbd6nbbmIdTslRFeqEZ3tdkNf7u5flQ7Z-Wj0ub9YZCGGHDADRYImAQTmQomRauwoK42xhjeIuN4UCwaZhZSUtGI7OggZZVFVhUcgFudz1bvvuY8Q0-CYmwLoOLXZj8pJLrpwVWk5WsbPC9GXqsfLbPjah__Kc-R-AfgfQTwD9L0Cvp9DFvn8sGiz_I3_E5Deuw2zy</recordid><startdate>20241120</startdate><enddate>20241120</enddate><creator>Schretter, Catherine E</creator><creator>Hindmarsh Sten, Tom</creator><creator>Klapoetke, Nathan</creator><creator>Shao, Mei</creator><creator>Nern, Aljoscha</creator><creator>Dreher, Marisa</creator><creator>Bushey, Daniel</creator><creator>Robie, Alice A</creator><creator>Taylor, Adam L</creator><creator>Branson, Kristin</creator><creator>Otopalik, Adriane</creator><creator>Ruta, Vanessa</creator><creator>Rubin, Gerald M</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0784-2927</orcidid><orcidid>https://orcid.org/0000-0002-4963-2768</orcidid><orcidid>https://orcid.org/0000-0002-3957-6838</orcidid><orcidid>https://orcid.org/0000-0001-8762-8703</orcidid><orcidid>https://orcid.org/0000-0002-5567-2512</orcidid><orcidid>https://orcid.org/0000-0001-6581-1603</orcidid><orcidid>https://orcid.org/0000-0002-3822-489X</orcidid></search><sort><creationdate>20241120</creationdate><title>Social state alters vision using three circuit mechanisms in Drosophila</title><author>Schretter, Catherine E ; Hindmarsh Sten, Tom ; Klapoetke, Nathan ; Shao, Mei ; Nern, Aljoscha ; Dreher, Marisa ; Bushey, Daniel ; Robie, Alice A ; Taylor, Adam L ; Branson, Kristin ; Otopalik, Adriane ; Ruta, Vanessa ; Rubin, Gerald M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-ccee7edecea49c32d0669fcb798b8741957b4c20158df38c71e98c6c3bffb8e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schretter, Catherine E</creatorcontrib><creatorcontrib>Hindmarsh Sten, Tom</creatorcontrib><creatorcontrib>Klapoetke, Nathan</creatorcontrib><creatorcontrib>Shao, Mei</creatorcontrib><creatorcontrib>Nern, Aljoscha</creatorcontrib><creatorcontrib>Dreher, Marisa</creatorcontrib><creatorcontrib>Bushey, Daniel</creatorcontrib><creatorcontrib>Robie, Alice A</creatorcontrib><creatorcontrib>Taylor, Adam L</creatorcontrib><creatorcontrib>Branson, Kristin</creatorcontrib><creatorcontrib>Otopalik, Adriane</creatorcontrib><creatorcontrib>Ruta, Vanessa</creatorcontrib><creatorcontrib>Rubin, Gerald M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schretter, Catherine E</au><au>Hindmarsh Sten, Tom</au><au>Klapoetke, Nathan</au><au>Shao, Mei</au><au>Nern, Aljoscha</au><au>Dreher, Marisa</au><au>Bushey, Daniel</au><au>Robie, Alice A</au><au>Taylor, Adam L</au><au>Branson, Kristin</au><au>Otopalik, Adriane</au><au>Ruta, Vanessa</au><au>Rubin, Gerald M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Social state alters vision using three circuit mechanisms in Drosophila</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>2024-11-20</date><risdate>2024</risdate><issn>0028-0836</issn><issn>1476-4687</issn><eissn>1476-4687</eissn><abstract>Animals are often bombarded with visual information and must prioritize specific visual features based on their current needs. The neuronal circuits that detect and relay visual features have been well studied . Much less is known about how an animal adjusts its visual attention as its goals or environmental conditions change. During social behaviours, flies need to focus on nearby flies . Here we study how the flow of visual information is altered when female Drosophila enter an aggressive state. From the connectome, we identify three state-dependent circuit motifs poised to modify the response of an aggressive female to fly-sized visual objects: convergence of excitatory inputs from neurons conveying select visual features and internal state; dendritic disinhibition of select visual feature detectors; and a switch that toggles between two visual feature detectors. Using cell-type-specific genetic tools, together with behavioural and neurophysiological analyses, we show that each of these circuit motifs is used during female aggression. We reveal that features of this same switch operate in male Drosophila during courtship pursuit, suggesting that disparate social behaviours may share circuit mechanisms. Our study provides a compelling example of using the connectome to infer circuit mechanisms that underlie dynamic processing of sensory signals.</abstract><cop>England</cop><pmid>39567699</pmid><doi>10.1038/s41586-024-08255-6</doi><orcidid>https://orcid.org/0000-0002-0784-2927</orcidid><orcidid>https://orcid.org/0000-0002-4963-2768</orcidid><orcidid>https://orcid.org/0000-0002-3957-6838</orcidid><orcidid>https://orcid.org/0000-0001-8762-8703</orcidid><orcidid>https://orcid.org/0000-0002-5567-2512</orcidid><orcidid>https://orcid.org/0000-0001-6581-1603</orcidid><orcidid>https://orcid.org/0000-0002-3822-489X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0028-0836
ispartof Nature (London), 2024-11
issn 0028-0836
1476-4687
1476-4687
language eng
recordid cdi_proquest_miscellaneous_3131498263
source Nature; Alma/SFX Local Collection
title Social state alters vision using three circuit mechanisms in Drosophila
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T06%3A10%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Social%20state%20alters%20vision%20using%20three%20circuit%20mechanisms%20in%20Drosophila&rft.jtitle=Nature%20(London)&rft.au=Schretter,%20Catherine%20E&rft.date=2024-11-20&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/s41586-024-08255-6&rft_dat=%3Cproquest_cross%3E3131498263%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3131498263&rft_id=info:pmid/39567699&rfr_iscdi=true