More than just DNA damage: Pt(ΙΙ)-NHC complexes derived from 4,5-diarylimidazoles augment immunogenic cell death

Platinum-based drugs are a mainstay in chemotherapy, with traditional forms exerting their work directly on DNA. In recent years, it has been observed that platinum complexes had the potential to induce immunogenic cell death (ICD) and effectively trigger antitumor immune responses. Herein, to obtai...

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Veröffentlicht in:	European journal of medicinal chemistry 2025-01, Vol.282, p.117014, Article 117014
Hauptverfasser:	Tang, Lu, Chang, Xingyu, Shi, Jing, Wen, Zhenfan, Bi, Chunyang, Liu, Wukun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Chemoimmunotherapy Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology DNA Damage Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Immunogenic cell death Immunogenic Cell Death - drug effects Liver Neoplasms - drug therapy Liver Neoplasms - pathology Mice Molecular Structure Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Platinum-based complex Reactive Oxygen Species - metabolism Structure-Activity Relationship
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