Modular Display of Plasmodium yoelii Circumsporozoite Surface Protein and Merozoite Surface Protein-1 on Norovirus-like Particles

Recently, virus-like particles have been regarded as a promising platform for displaying foreign peptides or proteins on their surface. In this study, a dual-protein-displaying platform based on the norovirus-like particle (NoV-LP) was developed using SpyTag (SpT)/SpyCatcher (SpC) protein bioconjuga...

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Veröffentlicht in:	Bioconjugate chemistry 2024-12, Vol.35 (12), p.1933-1943
Hauptverfasser:	Boonyakida, Jirayu, Nakayama, Kazuhiko, Kusakisako, Kodai, Ikadai, Hiromi, Park, Enoch Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Amino acids Animals Antigens Bispecific antibodies C-Terminus Circumsporozoite protein Developmental stages Enzyme-linked immunosorbent assay Female Immunogenicity Immunoglobulin G Malaria Malaria Vaccines - chemistry Malaria Vaccines - immunology Merozoite surface protein 1 Merozoite Surface Protein 1 - chemistry Merozoite Surface Protein 1 - immunology Mice Mice, Inbred BALB C Norovirus - immunology Parasites Peptides Plasmodium yoelii Plasmodium yoelii - immunology Proteins Protozoan Proteins - chemistry Protozoan Proteins - immunology Vaccines Vaccines, Virus-Like Particle - chemistry Vaccines, Virus-Like Particle - immunology Vector-borne diseases Virus-like particles VP1 protein
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