Unraveling the role of integrating signal peptides into natural collagen on modulating cancer cell adhesion

The signal peptides GVMGFO and GFOGER exhibit differential binding affinities towards Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and HT-1080 human fibrosarcoma cells, respectively, which in turn modulate the cell adhesion properties of natural collagen. GVMGFO demonstrates a more poten...

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Veröffentlicht in:	International journal of biological macromolecules 2024-12, Vol.283 (Pt 3), p.137808, Article 137808
Hauptverfasser:	Hou, Yuanjing, Li, Fang, Liu, Wei, Guo, Ruiming, Wu, Hui, Huang, Siying, Xu, Chengzhi, Zhu, Lian, Zhang, Juntao, Wei, Benmei, Wang, Haibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell adhesion Cell Adhesion - drug effects Cell Line, Tumor Collagen Collagen - chemistry Collagen - metabolism Discoidin Domain Receptor 1 - chemistry Discoidin Domain Receptor 1 - metabolism Humans Integrin alpha2beta1 - metabolism MCF-7 Cells Protein Binding Signal peptide
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