ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

Lactyl-coenzyme A (CoA)-dependent histone lysine lactylation impacts gene expression and plays fundamental roles in biological processes. However, mammalian lactyl-CoA synthetases and their regulation of histone lactylation have not yet been identified. Here, we demonstrate that epidermal growth fac...

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Veröffentlicht in:	Cell metabolism 2024-11, Vol.37 (2), p.361-376.e7
Hauptverfasser:	Zhu, Rongxuan, Ye, Xianglai, Lu, Xiaotong, Xiao, Liwei, Yuan, Ming, Zhao, Hong, Guo, Dong, Meng, Ying, Han, Hongkuan, Luo, Shudi, Wu, Qingang, Jiang, Xiaoming, Xu, Jun, Tang, Zhonghui, Tao, Yizhi Jane, Lu, Zhimin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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