Astragalus polysaccharide treatment relieves cerebral ischemia‒reperfusion injury by promoting M2 polarization of microglia by enhancing O-GlcNAcylation

Cerebral ischemia‒reperfusion (I/R) injury seriously threatens the lives of patients. Astragalus polysaccharide (APS) is the main active ingredient of Astragalus membranaceus and has a wide range of pharmacological activities. Here, we aimed to explore the impacts of APS on cerebral I/R injury and i...

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Veröffentlicht in:	Metabolic brain disease 2024-11, Vol.40 (1), p.16, Article 16
Hauptverfasser:	Wang, Mingyi, Zhu, Wenfeng, Guo, Yingmei, Zeng, Huan, Liu, Jincan, Liu, Jiemei, Zou, Yucong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - metabolism Animals Astragalus membranaceus Astragalus Plant - chemistry Biochemistry Biomedical and Life Sciences Biomedicine Brain Ischemia - drug therapy Brain Ischemia - metabolism CD16 antigen Cerebral blood flow Cytokines Glycosidases IL-1β Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - metabolism Injuries Interleukin 10 Interleukin 6 Interleukins Ischemia Male Metabolic Diseases Mice Microglia Microglia - drug effects Microglia - metabolism N-Acetylglucosamine Neurology Neurosciences O-GlcNAcylation Occlusion Oncology Original Article Polarization Polysaccharides Polysaccharides - pharmacology Polysaccharides - therapeutic use Rats Rats, Sprague-Dawley Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism
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