ERK5 is essential for early porcine embryonic development by maintaining Endoplasmic Reticulum homeostasis

•Inhibition of ERK5 could cause ER stress during porcine embryonic development.•The protein and mRNA expression levels of ERK5 decrease at the 4-cell stage.•Sustained ER stress induces apoptosis and autophagy. Extracellular signal-regulated kinase 5 (ERK5), a mitogen-activated protein kinase (MAPK)...

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Veröffentlicht in:	Gene 2025-02, Vol.936, p.149104, Article 149104
Hauptverfasser:	Lee, Gyu-Hyun, Lee, Song-Hee, Li, Xiao-Han, Lu, Qin-Yue, Zhan, Cheng-Lin, Kim, Ji-Dam, Sim, Jae-Min, Song, Hyeon-Ji, Sun, Ming-Hong, Cui, Xiang-Shun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autophagy Blastocyst - metabolism Embryonic Development - genetics Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Chaperone BiP - metabolism Endoplasmic Reticulum Stress ER stress Female Gene Expression Regulation, Developmental Homeostasis Mitogen-activated protein kinase Mitogen-Activated Protein Kinase 11 - genetics Mitogen-Activated Protein Kinase 11 - metabolism Mitogen-Activated Protein Kinase 7 - genetics Mitogen-Activated Protein Kinase 7 - metabolism Phosphorylation Swine Unfolded protein response
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