Glucose-1-phosphate thymidylyltransferase promotes the production of 3-O-α-mycarosylerythronolide B in Streptomyces coelicolor

The main objective of this study was to produce erythronolide B (EB) and 3-O-α-mycarosylerythronolide B (MEB) in Streptomyces coelicolor and enhance the MEB production by expressing the glucose-1-phosphate thymidylyltransferase (RfbA). We expressed eryF and eryB genes (eryBII, eryBIII, eryBIV, eryBV...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of applied microbiology 2024-12, Vol.135 (12)
Hauptverfasser:	Gao, Hong, Langer, Swen, Larson, Tony, Gregory, Matthew A, Smith, Margaret C M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - biosynthesis Bacterial Proteins - genetics Bacterial Proteins - metabolism Erythromycin - analogs & derivatives Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism Saccharopolyspora - enzymology Saccharopolyspora - genetics Saccharopolyspora - metabolism Streptomyces coelicolor - enzymology Streptomyces coelicolor - genetics Streptomyces coelicolor - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!