Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2MUT ovarian cancer models

Resistance to olaparib inevitably develops in ovarian cancer (OC) patients, highlighting the necessity for effective strategies to improve its efficacy. Here, we established a novel olaparib-resistant patient-derived xenograft model of high-grade serous OC with BRCA1/2 mutations and examined the mol...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochimica et biophysica acta. Molecular basis of disease 2025-02, Vol.1871 (2), p.167574, Article 167574
Hauptverfasser: Biegała, Łukasz, Statkiewicz, Małgorzata, Gajek, Arkadiusz, Szymczak-Pajor, Izabela, Rusetska, Natalia, Śliwińska, Agnieszka, Marczak, Agnieszka, Mikula, Michał, Rogalska, Aneta
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!