Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2MUT ovarian cancer models
Resistance to olaparib inevitably develops in ovarian cancer (OC) patients, highlighting the necessity for effective strategies to improve its efficacy. Here, we established a novel olaparib-resistant patient-derived xenograft model of high-grade serous OC with BRCA1/2 mutations and examined the mol...
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Veröffentlicht in: | Biochimica et biophysica acta. Molecular basis of disease 2025-02, Vol.1871 (2), p.167574, Article 167574 |
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Format: | Artikel |
Sprache: | eng |
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