Expression, purification, and biophysical analysis of a part of the C-terminal domain of human hypoxia inducible factor-2α (HIF-2α)

Hypoxia inducible factor 2α (HIF-2α) is a member of the basic helix-loop-helix(bHLH)-Per-Arnt-Sim (PAS) family of transcription factors. It is overexpressed in several cancers, associated with poor prognosis of the patients and resistance to treatment. Here, we study the residues 366-704 of the C-te...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-12, Vol.739, p.150965, Article 150965
Hauptverfasser:	Diseri, Aikaterini, Stravodimos, George, Argyriou, Aikaterini, Spyroulias, Georgios A., Leonidas, Demetres D., Liakos, Panagiotis
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Basic Helix-Loop-Helix Transcription Factors - chemistry Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Circular Dichroism Circular dichroism spectroscopy HIF-2α Humans Hypoxia Models, Molecular Protein Domains Protein purification Refolding
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