Alternative lengthening of telomere-based immortalization renders H3G34R -mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens

Diffuse hemispheric glioma, H3G34R/V-mutant (DHG-H3G34) is characterized by poor prognosis and lack of effective treatment options. DHG-H3G34R further harbor deactivation of Alpha-Thalassemia/Mental Retardation Syndrome X-linked protein (ATRX; DHG-H3G34R_ATRX) suggesting a unique interaction of thes...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2024-11
Hauptverfasser:	Laemmerer, Anna, Lehmann, Christian, Mayr, Lisa, Bruckner, Katharina, Gabler, Lisa, Senfter, Daniel, Meyer, Philipp, Balber, Theresa, Pirker, Christine, Jaunecker, Carola N, Kirchhofer, Dominik, Vician, Petra, Griesser, Michelle, Spiegl-Kreinecker, Sabine, Schmook, Maria T, Traub-Weidinger, Tatjana, Kuess, Peter, Eckert, Franziska, Federico, Aniello, Madlener, Sibylle, Stepien, Natalia, Robl, Bernhard, Baumgartner, Alicia, Hainfellner, Johannes A, Dieckmann, Karin, Dorfer, Christian, Roessler, Karl, Corsini, Nina S, Holzmann, Klaus, Schmidt, Wolfgang M, Peyrl, Andreas, Azizi, Amedeo A, Haberler, Christine, Beck, Alexander, Pfister, Stefan M, Schueler, Julia, Loetsch-Gojo, Daniela, Knoblich, Jürgen A, Berger, Walter, Gojo, Johannes
Format:	Artikel
Sprache:	eng
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