Markers of Environmental Enteric Dysfunction are Associated with Poor Growth and Developmental Outcomes among Young Children in Lusaka, Zambia
To examine cross-sectional relationships between biomarkers of environmental enteric dysfunction (EED), an acquired subclinical condition of the small intestine, and anthropometric and developmental outcomes among children in Lusaka, Zambia. Serum samples were collected from 240 children aged 27 to...
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| Veröffentlicht in: | The Journal of pediatrics 2024-11, Vol.277, p.114408, Article 114408 |
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| creator | Lauer, Jacqueline M. Pyykkö, Juha Chembe, Mpela Billima-Mulenga, Tamara Sikazwe, Dorothy Chibwe, Bertha Henderson, Savanna Parkerson, Doug Leppänen, Jukka M. Fink, Günther Locks, Lindsey M. Rockers, Peter C. |
| description | To examine cross-sectional relationships between biomarkers of environmental enteric dysfunction (EED), an acquired subclinical condition of the small intestine, and anthropometric and developmental outcomes among children in Lusaka, Zambia.
Serum samples were collected from 240 children aged 27 to 35 months enrolled in a cluster-randomized trial assessing the effects of growth charts and small-quantity lipid-based nutrient supplements on linear growth. Samples were analyzed using the 11-plex Micronutrient and EED Assessment Tool, which incorporates 2 biomarkers of EED, namely intestinal fatty acid-binding protein (I-FABP), a marker of epithelial damage, and soluble CD14 (sCD14), a marker of microbial translocation. Associations between log2-transformed biomarker concentrations and anthropometric (height-for-age z-score [HAZ], weight-for-height z-score, and weight-for-age z-score) and developmental (Global Scales of Early Development development for age z-score and saccadic reaction time [SRT]) outcomes were assessed using linear regression analyses adjusted for background characteristics.
Mean ± SD HAZ was −1.94 ± 1.10. Higher sCD14 and I-FABP concentrations were significantly associated with lower HAZ (β: −0.21, 95% CI: −0.41, −0.01 and β: −0.20, 95% CI: −0.32, −0.08, respectively). Higher I-FABP concentrations were significantly associated with lower development-for-age z-score (β: −0.22, 95% CI: −0.40, −0.03) and slower SRT (β: 7.37 ms, 95% CI: 2.02, 12.72) as were higher alpha-1-acid glycoprotein concentrations (HAZ β: −0.38, 95% CI: −0.72, −0.03; SRT β: 11.14 ms, 95% CI: 0.94, 21.72).
In children in Lusaka, biomarkers of EED were associated with poor anthropometric and developmental outcomes, underscoring the need for interventions to address EED to improve child health globally.
ClinicalTrials.gov identifier for parent trial: NCT05120427. https://clinicaltrials.gov/ct2/show/NCT05120427. |
| doi_str_mv | 10.1016/j.jpeds.2024.114408 |
| format | Article |
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Serum samples were collected from 240 children aged 27 to 35 months enrolled in a cluster-randomized trial assessing the effects of growth charts and small-quantity lipid-based nutrient supplements on linear growth. Samples were analyzed using the 11-plex Micronutrient and EED Assessment Tool, which incorporates 2 biomarkers of EED, namely intestinal fatty acid-binding protein (I-FABP), a marker of epithelial damage, and soluble CD14 (sCD14), a marker of microbial translocation. Associations between log2-transformed biomarker concentrations and anthropometric (height-for-age z-score [HAZ], weight-for-height z-score, and weight-for-age z-score) and developmental (Global Scales of Early Development development for age z-score and saccadic reaction time [SRT]) outcomes were assessed using linear regression analyses adjusted for background characteristics.
Mean ± SD HAZ was −1.94 ± 1.10. Higher sCD14 and I-FABP concentrations were significantly associated with lower HAZ (β: −0.21, 95% CI: −0.41, −0.01 and β: −0.20, 95% CI: −0.32, −0.08, respectively). Higher I-FABP concentrations were significantly associated with lower development-for-age z-score (β: −0.22, 95% CI: −0.40, −0.03) and slower SRT (β: 7.37 ms, 95% CI: 2.02, 12.72) as were higher alpha-1-acid glycoprotein concentrations (HAZ β: −0.38, 95% CI: −0.72, −0.03; SRT β: 11.14 ms, 95% CI: 0.94, 21.72).
In children in Lusaka, biomarkers of EED were associated with poor anthropometric and developmental outcomes, underscoring the need for interventions to address EED to improve child health globally.
ClinicalTrials.gov identifier for parent trial: NCT05120427. https://clinicaltrials.gov/ct2/show/NCT05120427.</description><identifier>ISSN: 0022-3476</identifier><identifier>ISSN: 1097-6833</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2024.114408</identifier><identifier>PMID: 39551093</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Africa ; child development ; child health ; environmental enteropathy ; eye-tracking ; inflammation ; intestinal fatty acid binding protein ; saccadic reaction time</subject><ispartof>The Journal of pediatrics, 2024-11, Vol.277, p.114408, Article 114408</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1543-d1e94867ad10a2e3ac30c4010b4264ba0ca8f5c0cfba060f21d36430904d0a1d3</cites><orcidid>0000-0001-8434-6583</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2024.114408$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39551093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lauer, Jacqueline M.</creatorcontrib><creatorcontrib>Pyykkö, Juha</creatorcontrib><creatorcontrib>Chembe, Mpela</creatorcontrib><creatorcontrib>Billima-Mulenga, Tamara</creatorcontrib><creatorcontrib>Sikazwe, Dorothy</creatorcontrib><creatorcontrib>Chibwe, Bertha</creatorcontrib><creatorcontrib>Henderson, Savanna</creatorcontrib><creatorcontrib>Parkerson, Doug</creatorcontrib><creatorcontrib>Leppänen, Jukka M.</creatorcontrib><creatorcontrib>Fink, Günther</creatorcontrib><creatorcontrib>Locks, Lindsey M.</creatorcontrib><creatorcontrib>Rockers, Peter C.</creatorcontrib><title>Markers of Environmental Enteric Dysfunction are Associated with Poor Growth and Developmental Outcomes among Young Children in Lusaka, Zambia</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To examine cross-sectional relationships between biomarkers of environmental enteric dysfunction (EED), an acquired subclinical condition of the small intestine, and anthropometric and developmental outcomes among children in Lusaka, Zambia.
Serum samples were collected from 240 children aged 27 to 35 months enrolled in a cluster-randomized trial assessing the effects of growth charts and small-quantity lipid-based nutrient supplements on linear growth. Samples were analyzed using the 11-plex Micronutrient and EED Assessment Tool, which incorporates 2 biomarkers of EED, namely intestinal fatty acid-binding protein (I-FABP), a marker of epithelial damage, and soluble CD14 (sCD14), a marker of microbial translocation. Associations between log2-transformed biomarker concentrations and anthropometric (height-for-age z-score [HAZ], weight-for-height z-score, and weight-for-age z-score) and developmental (Global Scales of Early Development development for age z-score and saccadic reaction time [SRT]) outcomes were assessed using linear regression analyses adjusted for background characteristics.
Mean ± SD HAZ was −1.94 ± 1.10. Higher sCD14 and I-FABP concentrations were significantly associated with lower HAZ (β: −0.21, 95% CI: −0.41, −0.01 and β: −0.20, 95% CI: −0.32, −0.08, respectively). Higher I-FABP concentrations were significantly associated with lower development-for-age z-score (β: −0.22, 95% CI: −0.40, −0.03) and slower SRT (β: 7.37 ms, 95% CI: 2.02, 12.72) as were higher alpha-1-acid glycoprotein concentrations (HAZ β: −0.38, 95% CI: −0.72, −0.03; SRT β: 11.14 ms, 95% CI: 0.94, 21.72).
In children in Lusaka, biomarkers of EED were associated with poor anthropometric and developmental outcomes, underscoring the need for interventions to address EED to improve child health globally.
ClinicalTrials.gov identifier for parent trial: NCT05120427. https://clinicaltrials.gov/ct2/show/NCT05120427.</description><subject>Africa</subject><subject>child development</subject><subject>child health</subject><subject>environmental enteropathy</subject><subject>eye-tracking</subject><subject>inflammation</subject><subject>intestinal fatty acid binding protein</subject><subject>saccadic reaction time</subject><issn>0022-3476</issn><issn>1097-6833</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAQxy0EotvCEyAhHzmQZRw7yebAodp-gLSoHOAAF2vWnlBvE3uxk636FLwCz8KT4bJLj73Mh_Sb-Wvmz9grAXMBon63mW-2ZNO8hFLNhVAKFk_YTEDbFPVCyqdsBlCWhVRNfcSOU9oAQKsAnrMj2VZVBuWM_fqE8YZi4qHj537nYvAD-RH73I0UneFnd6mbvBld8Bwj8dOUgnE4kuW3brzmn0OI_DKG21yjt_yMdtSH7WHL1TSaMFDiOAT_g38LU47La9fbSJ47z1dTwht8--f3dxzWDl-wZx32iV4e8gn7enH-ZfmhWF1dflyergojKiULK6hVi7pBKwBLkmgkGAUC1qqs1RrB4KKrDJgu1zV0pbCyVhJaUBYwNyfszX7vNoafE6VRDy4Z6nv0FKakpSjb_MWqaTIq96iJIaVInd5GN2C80wL0vRN6o_85oe-d0Hsn8tTrg8C0Hsg-zPx_fQbe7wHKZ-4cRZ2MI2_Iukhm1Da4RwX-AknxnXE</recordid><startdate>20241117</startdate><enddate>20241117</enddate><creator>Lauer, Jacqueline M.</creator><creator>Pyykkö, Juha</creator><creator>Chembe, Mpela</creator><creator>Billima-Mulenga, Tamara</creator><creator>Sikazwe, Dorothy</creator><creator>Chibwe, Bertha</creator><creator>Henderson, Savanna</creator><creator>Parkerson, Doug</creator><creator>Leppänen, Jukka M.</creator><creator>Fink, Günther</creator><creator>Locks, Lindsey M.</creator><creator>Rockers, Peter C.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8434-6583</orcidid></search><sort><creationdate>20241117</creationdate><title>Markers of Environmental Enteric Dysfunction are Associated with Poor Growth and Developmental Outcomes among Young Children in Lusaka, Zambia</title><author>Lauer, Jacqueline M. ; Pyykkö, Juha ; Chembe, Mpela ; Billima-Mulenga, Tamara ; Sikazwe, Dorothy ; Chibwe, Bertha ; Henderson, Savanna ; Parkerson, Doug ; Leppänen, Jukka M. ; Fink, Günther ; Locks, Lindsey M. ; Rockers, Peter C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1543-d1e94867ad10a2e3ac30c4010b4264ba0ca8f5c0cfba060f21d36430904d0a1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Africa</topic><topic>child development</topic><topic>child health</topic><topic>environmental enteropathy</topic><topic>eye-tracking</topic><topic>inflammation</topic><topic>intestinal fatty acid binding protein</topic><topic>saccadic reaction time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lauer, Jacqueline M.</creatorcontrib><creatorcontrib>Pyykkö, Juha</creatorcontrib><creatorcontrib>Chembe, Mpela</creatorcontrib><creatorcontrib>Billima-Mulenga, Tamara</creatorcontrib><creatorcontrib>Sikazwe, Dorothy</creatorcontrib><creatorcontrib>Chibwe, Bertha</creatorcontrib><creatorcontrib>Henderson, Savanna</creatorcontrib><creatorcontrib>Parkerson, Doug</creatorcontrib><creatorcontrib>Leppänen, Jukka M.</creatorcontrib><creatorcontrib>Fink, Günther</creatorcontrib><creatorcontrib>Locks, Lindsey M.</creatorcontrib><creatorcontrib>Rockers, Peter C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lauer, Jacqueline M.</au><au>Pyykkö, Juha</au><au>Chembe, Mpela</au><au>Billima-Mulenga, Tamara</au><au>Sikazwe, Dorothy</au><au>Chibwe, Bertha</au><au>Henderson, Savanna</au><au>Parkerson, Doug</au><au>Leppänen, Jukka M.</au><au>Fink, Günther</au><au>Locks, Lindsey M.</au><au>Rockers, Peter C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Markers of Environmental Enteric Dysfunction are Associated with Poor Growth and Developmental Outcomes among Young Children in Lusaka, Zambia</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2024-11-17</date><risdate>2024</risdate><volume>277</volume><spage>114408</spage><pages>114408-</pages><artnum>114408</artnum><issn>0022-3476</issn><issn>1097-6833</issn><eissn>1097-6833</eissn><abstract>To examine cross-sectional relationships between biomarkers of environmental enteric dysfunction (EED), an acquired subclinical condition of the small intestine, and anthropometric and developmental outcomes among children in Lusaka, Zambia.
Serum samples were collected from 240 children aged 27 to 35 months enrolled in a cluster-randomized trial assessing the effects of growth charts and small-quantity lipid-based nutrient supplements on linear growth. Samples were analyzed using the 11-plex Micronutrient and EED Assessment Tool, which incorporates 2 biomarkers of EED, namely intestinal fatty acid-binding protein (I-FABP), a marker of epithelial damage, and soluble CD14 (sCD14), a marker of microbial translocation. Associations between log2-transformed biomarker concentrations and anthropometric (height-for-age z-score [HAZ], weight-for-height z-score, and weight-for-age z-score) and developmental (Global Scales of Early Development development for age z-score and saccadic reaction time [SRT]) outcomes were assessed using linear regression analyses adjusted for background characteristics.
Mean ± SD HAZ was −1.94 ± 1.10. Higher sCD14 and I-FABP concentrations were significantly associated with lower HAZ (β: −0.21, 95% CI: −0.41, −0.01 and β: −0.20, 95% CI: −0.32, −0.08, respectively). Higher I-FABP concentrations were significantly associated with lower development-for-age z-score (β: −0.22, 95% CI: −0.40, −0.03) and slower SRT (β: 7.37 ms, 95% CI: 2.02, 12.72) as were higher alpha-1-acid glycoprotein concentrations (HAZ β: −0.38, 95% CI: −0.72, −0.03; SRT β: 11.14 ms, 95% CI: 0.94, 21.72).
In children in Lusaka, biomarkers of EED were associated with poor anthropometric and developmental outcomes, underscoring the need for interventions to address EED to improve child health globally.
ClinicalTrials.gov identifier for parent trial: NCT05120427. https://clinicaltrials.gov/ct2/show/NCT05120427.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39551093</pmid><doi>10.1016/j.jpeds.2024.114408</doi><orcidid>https://orcid.org/0000-0001-8434-6583</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Africa child development child health environmental enteropathy eye-tracking inflammation intestinal fatty acid binding protein saccadic reaction time |
| title | Markers of Environmental Enteric Dysfunction are Associated with Poor Growth and Developmental Outcomes among Young Children in Lusaka, Zambia |
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