The calcium‐sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin β1‐NLRP3 inflammasome

Atherosclerosis (AS) is a chronic inflammatory disease of arteries. Endothelial inflammation is key to the initiation and development of AS. The calcium‐sensing receptor (CaSR) is expressed in endothelial cells (ECs) but its role in endothelial inflammation during AS remains unclear. This study focu...

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Veröffentlicht in:	The FEBS journal 2024-11, Vol.292 (1), p.191-205
Hauptverfasser:	Jiang, Yunge, Xing, Wenjing, Li, Zhong, Zhao, Defeng, Xiu, Bingxu, Xi, Yuhui, Bai, Shuzhi, Li, Xiaoxue, Zhang, Zheqi, Zhang, Weihua, Li, Hongxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Aorta Apolipoprotein E Arteries Arteriosclerosis Atherosclerosis Calcium Calcium-sensing receptors calcium‐sensing receptor Cell adhesion Cell adhesion molecules Down-regulation Endothelial cells endothelial inflammation High fat diet Inflammasomes Inflammation Inflammatory diseases integrin β1 NLRP3 inflammasome Receptors Therapeutic applications Umbilical vein
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