Synthesis of Formononetin Derivatives and Cardioprotective Effects

This study aims to design and synthesize a series of novel formononetin (FMN) derivatives and explore their protective effects on oxygen glucose deprivation/relapse (OGD/R) damage to H9C2 cells, along with their molecular regulatory mechanisms. The OGD/R model was established to simulate myocardial...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2024/11/15, Vol.72(11), pp.970-978
Hauptverfasser:	Luo, Zeping, Pan, Liwei
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Apoptosis Apoptosis - drug effects Aspartate aminotransferase Autophagy Autophagy - drug effects Cardiomyocytes cardioprotective effect Cardiotonic Agents - chemical synthesis Cardiotonic Agents - chemistry Cardiotonic Agents - pharmacology Cell Line Cell Survival - drug effects Damage Diltiazem Dose-Response Relationship, Drug Enzymatic activity Enzyme activity Enzymes formononetin derivative Glucose - metabolism Ischemia Isoflavones - chemical synthesis Isoflavones - chemistry Isoflavones - pharmacology Kinases L-Lactate dehydrogenase Lactate dehydrogenase Molecular Structure Myocardial ischemia Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Phagosomes Phosphatidylinositol Phosphatidylinositol 3-Kinases - metabolism Proteins Rats Regulatory mechanisms (biology) Reperfusion Signal transduction Structure-Activity Relationship Transmission electron microscopy Western blotting
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