ONC206, an imipridone derivative, demonstrates anti-colorectal cancer activity against stem/progenitor cells in 3D cell cultures and in patient-derived organoids

Colorectal cancer (CRC) remains one of the most frequently diagnosed and life-threatening malignancies worldwide. CRC's high recurrence rates and drug resistance have been correlated with a subpopulation of dormant slowly dividing cells termed CRC stem cells (CCSCs). Consequently, there is a pr...

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Veröffentlicht in:	Pharmacological reports 2025-02, Vol.77 (1), p.229-246
Hauptverfasser:	Monzer, Alissar, Ghamlouche, Fatima, Wakimian, Kevork, Ballout, Farah, Al Bitar, Samar, Yehya, Amani, Kanso, Mariam, Saheb, Nour, Tawil, Ayman, Doughan, Samer, Hussein, Maher, Mukherji, Deborah, Faraj, Walid, Allen, Joshua E, Prabhu, Varun V, Abou-Antoun, Tamara, Gali-Muhtasib, Hala, Abou-Kheir, Wassim
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Benzyl Compounds Cell Culture Techniques, Three Dimensional - methods Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology HCT116 Cells Heterocyclic Compounds, 3-Ring HT29 Cells Humans Neoplastic Stem Cells - drug effects Organoids - drug effects
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