Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson’s disease induced by rotenone

•A Parkin-NLRP3 negative feedback loop participated in rotenone induced PD.•Rotenone caused pyroptosis via NLRP3 inflammasome in dopamine neurons.•Rotenone caused Parkin inactivity and failed to ubiquitinated NLRP3.•MCC950 restored Parkin activity and inhibited NLRP3-mediated pyroptosis. Rotenone re...

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Veröffentlicht in:	International immunopharmacology 2024-12, Vol.143 (Pt 3), p.113608, Article 113608
Hauptverfasser:	Zheng, Dongyan, Lai, Yixi, Huang, Kailun, Guan, Duanqin, Xie, Zhefan, Fu, Chunlai, Liu, Linhua, Huang, Jiewen, Gong, Liya, Li, Jianqiang, Zhang, He, Chen, Jialong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Feedback, Physiological Humans Inflammasomes - metabolism Male Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Parkin-NLRP3 negative feedback loop Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson’s disease Pyroptosis Pyroptosis - drug effects Rotenone Rotenone - toxicity Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination - drug effects
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