Unraveling the Structural Basis of Biased Agonism in the β2-Adrenergic Receptor Through Molecular Dynamics Simulations

Biased agonism in G protein-coupled receptors is a phenomenon resulting in the selective activation of distinct intracellular signaling pathways by different agonists, which may exhibit bias toward either Gs, Gi, or arrestin-mediated pathways. This study investigates the structural basis of ligand-i...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2024-11
Hauptverfasser:	Plazinski, Wojciech, Archala, Aneta, Jozwiak, Krzysztof, Plazinska, Anita
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!