Acute Behavioral and Neurochemical Effects of Sulpiride in Adult Zebrafish
Affective and psychotic disorders are highly prevalent and severely debilitating mental illnesses that often remain untreated or treatment-resistant. Sulpiride is a common antipsychotic (neuroleptic) drug whose well-established additional (e.g., antidepressant) therapeutic effects call for further s...
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| Veröffentlicht in: | Neurochemical research 2025-02, Vol.50 (1), p.11, Article 11 |
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| creator | Galstyan, David S. Lebedev, Andrey S. Ilyin, Nikita P. Papulova, Maria S. Golushko, Nikita I. Tishkina, Valeria V. Saklakova, Daryna K. Martynov, Daniil Kolesnikova, Tatiana O. Rosemberg, Dennis B. De Abreu, Murilo S. Demin, Konstantin A. Kalueff, Allan V. |
| description | Affective and psychotic disorders are highly prevalent and severely debilitating mental illnesses that often remain untreated or treatment-resistant. Sulpiride is a common antipsychotic (neuroleptic) drug whose well-established additional (e.g., antidepressant) therapeutic effects call for further studies of a wider spectrum of its CNS effects. Here, we examined effects of acute 20-min exposure to sulpiride (50–200 mg/L) on anxiety- and depression-like behaviors, as well as on brain monoamines, in adult zebrafish (
Danio rerio
). Overall, sulpiride exerted overt anxiolytic-like effects in the novel tank test and showed tranquilizing-like effects in the zebrafish tail immobilization test, accompanied by lowered whole-brain dopamine and its elevated turnover, without affecting serotonin or norepinephrine levels and their turnover. Taken together, these findings support complex behavioral pharmacology of sulpiride in vivo and reconfirm high sensitivity of zebrafish-based screens to this and, likely, other related clinically active neuroleptics. |
| doi_str_mv | 10.1007/s11064-024-04268-9 |
| format | Article |
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Danio rerio
). Overall, sulpiride exerted overt anxiolytic-like effects in the novel tank test and showed tranquilizing-like effects in the zebrafish tail immobilization test, accompanied by lowered whole-brain dopamine and its elevated turnover, without affecting serotonin or norepinephrine levels and their turnover. Taken together, these findings support complex behavioral pharmacology of sulpiride in vivo and reconfirm high sensitivity of zebrafish-based screens to this and, likely, other related clinically active neuroleptics.</description><identifier>ISSN: 0364-3190</identifier><identifier>ISSN: 1573-6903</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-024-04268-9</identifier><identifier>PMID: 39549192</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Anti-Anxiety Agents - pharmacology ; Anti-Anxiety Agents - therapeutic use ; Antidepressants ; Antipsychotic Agents - pharmacology ; Antipsychotics ; Anxiety ; Anxiety - drug therapy ; Anxiety - metabolism ; Anxiolytics ; Behavior ; Behavior, Animal - drug effects ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain - drug effects ; Brain - metabolism ; Brain research ; Cell Biology ; Comorbidity ; Danio rerio ; Depression - drug therapy ; Depression - metabolism ; Dopamine ; Dopamine - metabolism ; Female ; Hallucinations ; Health sciences ; Immobilization ; In vivo methods and tests ; Male ; Medical research ; Mental depression ; Mental disorders ; Monoamines ; Neurobiology ; Neurochemistry ; Neurology ; Neurosciences ; Norepinephrine ; Norepinephrine - metabolism ; Pharmacology ; Population ; Psychosis ; Psychotropic drugs ; Schizophrenia ; Serotonin ; Serotonin - metabolism ; Sulpiride ; Sulpiride - pharmacology ; Zebrafish</subject><ispartof>Neurochemical research, 2025-02, Vol.50 (1), p.11, Article 11</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>Copyright Springer Nature B.V. Feb 2025</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-5d96899c901f208a013bdd2965ec345bfe6ea24cfb68ae6e41f6d955eb0f64113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-024-04268-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-024-04268-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39549192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galstyan, David S.</creatorcontrib><creatorcontrib>Lebedev, Andrey S.</creatorcontrib><creatorcontrib>Ilyin, Nikita P.</creatorcontrib><creatorcontrib>Papulova, Maria S.</creatorcontrib><creatorcontrib>Golushko, Nikita I.</creatorcontrib><creatorcontrib>Tishkina, Valeria V.</creatorcontrib><creatorcontrib>Saklakova, Daryna K.</creatorcontrib><creatorcontrib>Martynov, Daniil</creatorcontrib><creatorcontrib>Kolesnikova, Tatiana O.</creatorcontrib><creatorcontrib>Rosemberg, Dennis B.</creatorcontrib><creatorcontrib>De Abreu, Murilo S.</creatorcontrib><creatorcontrib>Demin, Konstantin A.</creatorcontrib><creatorcontrib>Kalueff, Allan V.</creatorcontrib><title>Acute Behavioral and Neurochemical Effects of Sulpiride in Adult Zebrafish</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Affective and psychotic disorders are highly prevalent and severely debilitating mental illnesses that often remain untreated or treatment-resistant. Sulpiride is a common antipsychotic (neuroleptic) drug whose well-established additional (e.g., antidepressant) therapeutic effects call for further studies of a wider spectrum of its CNS effects. Here, we examined effects of acute 20-min exposure to sulpiride (50–200 mg/L) on anxiety- and depression-like behaviors, as well as on brain monoamines, in adult zebrafish (
Danio rerio
). Overall, sulpiride exerted overt anxiolytic-like effects in the novel tank test and showed tranquilizing-like effects in the zebrafish tail immobilization test, accompanied by lowered whole-brain dopamine and its elevated turnover, without affecting serotonin or norepinephrine levels and their turnover. Taken together, these findings support complex behavioral pharmacology of sulpiride in vivo and reconfirm high sensitivity of zebrafish-based screens to this and, likely, other related clinically active neuroleptics.</description><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Anti-Anxiety Agents - therapeutic use</subject><subject>Antidepressants</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Antipsychotics</subject><subject>Anxiety</subject><subject>Anxiety - drug therapy</subject><subject>Anxiety - metabolism</subject><subject>Anxiolytics</subject><subject>Behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain research</subject><subject>Cell Biology</subject><subject>Comorbidity</subject><subject>Danio rerio</subject><subject>Depression - drug therapy</subject><subject>Depression - metabolism</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Female</subject><subject>Hallucinations</subject><subject>Health sciences</subject><subject>Immobilization</subject><subject>In vivo methods and tests</subject><subject>Male</subject><subject>Medical research</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Monoamines</subject><subject>Neurobiology</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Pharmacology</subject><subject>Population</subject><subject>Psychosis</subject><subject>Psychotropic drugs</subject><subject>Schizophrenia</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Sulpiride</subject><subject>Sulpiride - pharmacology</subject><subject>Zebrafish</subject><issn>0364-3190</issn><issn>1573-6903</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PwyAYh4nRuDn9Ah5MEy9eqrxQWDlOM__F6EG9eCGUvrguXTuhNfHbi9vUxIMHAuF9fj_IQ8gh0FOgdHwWAKjMUsriypjMU7VFhiDGPJWK8m0ypDyOOSg6IHshzCmNMQa7ZMCVyBQoNiS3E9t3mJzjzLxXrTd1Ypoyucfet3aGi8rGm6lzaLuQtC557Otl5asSk6pJJmVfd8kLFt64Ksz2yY4zdcCDzT4iz5fTp4vr9O7h6uZicpdaJmSXilLJXCmrKDhGc0OBF2XJlBRoeSYKhxINy6wrZG7iOQMnSyUEFtTJDICPyMm6d-nbtx5DpxdVsFjXpsG2D5oDUwzyMZMRPf6DztveN_F3K4oKyEFFiq0p69sQPDq99NXC-A8NVH-Z1mvTOprWK9P6K3S0qe6LBZY_kW-1EeBrIMRR84r-9-1_aj8Bgk6HnQ</recordid><startdate>20250201</startdate><enddate>20250201</enddate><creator>Galstyan, David S.</creator><creator>Lebedev, Andrey S.</creator><creator>Ilyin, Nikita P.</creator><creator>Papulova, Maria S.</creator><creator>Golushko, Nikita I.</creator><creator>Tishkina, Valeria V.</creator><creator>Saklakova, Daryna K.</creator><creator>Martynov, Daniil</creator><creator>Kolesnikova, Tatiana O.</creator><creator>Rosemberg, Dennis B.</creator><creator>De Abreu, Murilo S.</creator><creator>Demin, Konstantin A.</creator><creator>Kalueff, Allan V.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20250201</creationdate><title>Acute Behavioral and Neurochemical Effects of Sulpiride in Adult Zebrafish</title><author>Galstyan, David S. ; 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Sulpiride is a common antipsychotic (neuroleptic) drug whose well-established additional (e.g., antidepressant) therapeutic effects call for further studies of a wider spectrum of its CNS effects. Here, we examined effects of acute 20-min exposure to sulpiride (50–200 mg/L) on anxiety- and depression-like behaviors, as well as on brain monoamines, in adult zebrafish (
Danio rerio
). Overall, sulpiride exerted overt anxiolytic-like effects in the novel tank test and showed tranquilizing-like effects in the zebrafish tail immobilization test, accompanied by lowered whole-brain dopamine and its elevated turnover, without affecting serotonin or norepinephrine levels and their turnover. Taken together, these findings support complex behavioral pharmacology of sulpiride in vivo and reconfirm high sensitivity of zebrafish-based screens to this and, likely, other related clinically active neuroleptics.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39549192</pmid><doi>10.1007/s11064-024-04268-9</doi></addata></record> |
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| subjects | Animals Anti-Anxiety Agents - pharmacology Anti-Anxiety Agents - therapeutic use Antidepressants Antipsychotic Agents - pharmacology Antipsychotics Anxiety Anxiety - drug therapy Anxiety - metabolism Anxiolytics Behavior Behavior, Animal - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - metabolism Brain research Cell Biology Comorbidity Danio rerio Depression - drug therapy Depression - metabolism Dopamine Dopamine - metabolism Female Hallucinations Health sciences Immobilization In vivo methods and tests Male Medical research Mental depression Mental disorders Monoamines Neurobiology Neurochemistry Neurology Neurosciences Norepinephrine Norepinephrine - metabolism Pharmacology Population Psychosis Psychotropic drugs Schizophrenia Serotonin Serotonin - metabolism Sulpiride Sulpiride - pharmacology Zebrafish |
| title | Acute Behavioral and Neurochemical Effects of Sulpiride in Adult Zebrafish |
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