Ubiquitination and degradation of MHC-II by Tim-3 inhibits antiviral immunity

•Tim-3 inhibits MHC-II expression and induces proteasome-dependent degradation of MHC-II during H1N1 infection in vitro.•Tim-3 promotes the K48-linked ubiquitination of MHC-II via MARCH8.•Tim-3 promotes virus immune evasion by decreasing the differentiation of the effector CD4+T cells. We previously...

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Veröffentlicht in:	Cellular immunology 2025-01, Vol.407, p.104889, Article 104889
Hauptverfasser:	Zhou, Jie, LV, Zhonglin, Liu, Meichen, Du, Chunxiao, Du, Lin, Gao, Zhenfang, Jiang, Ziying, Wang, Lanying, Wang, Shuohua, Liang, Meng, Xie, Shun, Li, Yuxiang, Wang, Zhiding, Li, Ge, Wei, Yinxiang, Han, Gencheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals HEK293 Cells Hepatitis A Virus Cellular Receptor 2 - immunology Hepatitis A Virus Cellular Receptor 2 - metabolism Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Humans Immune evasion Immune Evasion - immunology Macrophages - immunology Macrophages - metabolism MARCH8 MHC-II Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - metabolism Proteolysis Signal Transduction - immunology Tim-3 Ubiquitin-Protein Ligases - immunology Ubiquitin-Protein Ligases - metabolism Ubiquitination
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