Curative-intent surgery for solitary bone metastasis from extremity and trunk wall sarcoma: What are the outcomes and complications?
Approximately 40–50 % of sarcoma patients will develop lung metastasis, but only 10 % will develop bone metastasis. The survival benefit of surgery for solitary bone metastasis remains unclear. From 1987 to 2019, 47 patients who underwent curative-intent treatment for localized bone or soft tissue s...
Gespeichert in:
| Veröffentlicht in: | European journal of surgical oncology 2025-01, Vol.51 (1), p.109369, Article 109369 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 109369 |
| container_title | European journal of surgical oncology |
| container_volume | 51 |
| creator | Zhang, Liuzhe Mattei, Jean-Camille Griffin, Anthony M. Tsoi, Kim Ferguson, Peter C. Wunder, Jay S. |
| description | Approximately 40–50 % of sarcoma patients will develop lung metastasis, but only 10 % will develop bone metastasis. The survival benefit of surgery for solitary bone metastasis remains unclear.
From 1987 to 2019, 47 patients who underwent curative-intent treatment for localized bone or soft tissue sarcoma in the extremities or trunk wall developed solitary bone metastases as the first distant recurrence. Of them, 51 % (24/47) received curative-intent metastasectomy. We compared the clinicopathologic characteristics of the metastasectomy versus non-metastasectomy patients and evaluated the prognostic impact of solitary bone metastasectomy. The primary outcome measure was disease-specific survival (DSS) after developing solitary bone metastasis.
The post-metastasis DSS was worse with larger primary tumour size (HR 1.09; 95 % CI 1.02–1.16; p = 0.01) and bone metastasis in the pelvis or spine versus other bones (HR 3.79, 95 % CI 1.46–9.87; p = 0.01), and better with curative-intent surgery for the solitary bone metastasis (HR 0.14; 95 % CI 0.06–0.34; p |
| doi_str_mv | 10.1016/j.ejso.2024.109369 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3128980757</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0748798324014379</els_id><sourcerecordid>3128980757</sourcerecordid><originalsourceid>FETCH-LOGICAL-c237t-9664382b3f1b16a80ae2dbfb67da712968aabd20b6d4153b22cae669f40cfa2c3</originalsourceid><addsrcrecordid>eNp9kM9rFDEUx4Modlv9BzxIjl5mzY_ZZCKClEVroeCl4jG8ZN7YrDOTNclUe-8fbtatPQqBlzw-7xveh5BXnK054-rtbo27HNeCibY2jFTmCVnxjRSN4Bv9lKyYbrtGm06ekNOcd4xVSJvn5ESaTau5FCtyv10SlHCLTZgLzoXmJX3HdEeHmGiOYyhQHy7OSCcskOsJmQ4pThR_l4RTKHcU5p6WtMw_6C8YR5oh-TjBO_rtBgqFhLTcII1LqV3Mf-l624_B15_jnD-8IM8GGDO-fKhn5Ounj9fbz83Vl4vL7flV44XUpTFKtbITTg7ccQUdAxS9G5zSPWgujOoAXC-YU31bNTghPKBSZmiZH0B4eUbeHHP3Kf5cMBc7hexxHGHGuGQruehMx_RGV1QcUZ9izgkHu09hqi4sZ_Zg3-7swb492LdH-3Xo9UP-4ibsH0f-6a7A-yOAdcvbgMlmH3D22IeEvtg-hv_l_wEXB5lw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3128980757</pqid></control><display><type>article</type><title>Curative-intent surgery for solitary bone metastasis from extremity and trunk wall sarcoma: What are the outcomes and complications?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Zhang, Liuzhe ; Mattei, Jean-Camille ; Griffin, Anthony M. ; Tsoi, Kim ; Ferguson, Peter C. ; Wunder, Jay S.</creator><creatorcontrib>Zhang, Liuzhe ; Mattei, Jean-Camille ; Griffin, Anthony M. ; Tsoi, Kim ; Ferguson, Peter C. ; Wunder, Jay S.</creatorcontrib><description>Approximately 40–50 % of sarcoma patients will develop lung metastasis, but only 10 % will develop bone metastasis. The survival benefit of surgery for solitary bone metastasis remains unclear.
From 1987 to 2019, 47 patients who underwent curative-intent treatment for localized bone or soft tissue sarcoma in the extremities or trunk wall developed solitary bone metastases as the first distant recurrence. Of them, 51 % (24/47) received curative-intent metastasectomy. We compared the clinicopathologic characteristics of the metastasectomy versus non-metastasectomy patients and evaluated the prognostic impact of solitary bone metastasectomy. The primary outcome measure was disease-specific survival (DSS) after developing solitary bone metastasis.
The post-metastasis DSS was worse with larger primary tumour size (HR 1.09; 95 % CI 1.02–1.16; p = 0.01) and bone metastasis in the pelvis or spine versus other bones (HR 3.79, 95 % CI 1.46–9.87; p = 0.01), and better with curative-intent surgery for the solitary bone metastasis (HR 0.14; 95 % CI 0.06–0.34; p < 0.001). The median DSS was 43 (95 % CI, 24–69) months for the metastasectomy group vs. 13 (95 % CI, 7–19) months for the non-metastasectomy group (p < 0.001). The metastasectomy group had fewer patients with metastasis in the spine or pelvis and longer metastasis-free interval. In the multivariate analysis, curative-intent surgery for solitary bone metastasis was associated with better survival (HR 0.21; 95 % CI 0.08–0.53; p = 0.001).
Curative-intent surgery for solitary bone metastasis from sarcoma is associated with a better prognosis and is a reasonable treatment strategy whenever feasible.
Synopsis: Curative-intent en-bloc resection of solitary bone metastasis from sarcoma was associated with improved disease-specific survival. The perioperative complication rate following metastasectomy was similar to that for primary bone sarcomas.</description><identifier>ISSN: 0748-7983</identifier><identifier>ISSN: 1532-2157</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2024.109369</identifier><identifier>PMID: 39547132</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Bone Neoplasms - secondary ; Bone Neoplasms - surgery ; Complication ; Disease-specific survival ; en-bloc resection ; Extremities - surgery ; Female ; Humans ; Male ; Metastasectomy ; Metastasis-free survival ; Middle Aged ; Prognosis ; Retrospective Studies ; Sarcoma - pathology ; Sarcoma - secondary ; Sarcoma - surgery ; Soft Tissue Neoplasms - pathology ; Soft Tissue Neoplasms - secondary ; Soft Tissue Neoplasms - surgery ; Survival Rate ; Torso ; Tumor Burden ; Young Adult</subject><ispartof>European journal of surgical oncology, 2025-01, Vol.51 (1), p.109369, Article 109369</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c237t-9664382b3f1b16a80ae2dbfb67da712968aabd20b6d4153b22cae669f40cfa2c3</cites><orcidid>0000-0002-6260-3267 ; 0000-0003-4329-2333 ; 0000-0003-0656-2365 ; 0000-0003-4462-3974 ; 0000-0002-5978-9400</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0748798324014379$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39547132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Liuzhe</creatorcontrib><creatorcontrib>Mattei, Jean-Camille</creatorcontrib><creatorcontrib>Griffin, Anthony M.</creatorcontrib><creatorcontrib>Tsoi, Kim</creatorcontrib><creatorcontrib>Ferguson, Peter C.</creatorcontrib><creatorcontrib>Wunder, Jay S.</creatorcontrib><title>Curative-intent surgery for solitary bone metastasis from extremity and trunk wall sarcoma: What are the outcomes and complications?</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Approximately 40–50 % of sarcoma patients will develop lung metastasis, but only 10 % will develop bone metastasis. The survival benefit of surgery for solitary bone metastasis remains unclear.
From 1987 to 2019, 47 patients who underwent curative-intent treatment for localized bone or soft tissue sarcoma in the extremities or trunk wall developed solitary bone metastases as the first distant recurrence. Of them, 51 % (24/47) received curative-intent metastasectomy. We compared the clinicopathologic characteristics of the metastasectomy versus non-metastasectomy patients and evaluated the prognostic impact of solitary bone metastasectomy. The primary outcome measure was disease-specific survival (DSS) after developing solitary bone metastasis.
The post-metastasis DSS was worse with larger primary tumour size (HR 1.09; 95 % CI 1.02–1.16; p = 0.01) and bone metastasis in the pelvis or spine versus other bones (HR 3.79, 95 % CI 1.46–9.87; p = 0.01), and better with curative-intent surgery for the solitary bone metastasis (HR 0.14; 95 % CI 0.06–0.34; p < 0.001). The median DSS was 43 (95 % CI, 24–69) months for the metastasectomy group vs. 13 (95 % CI, 7–19) months for the non-metastasectomy group (p < 0.001). The metastasectomy group had fewer patients with metastasis in the spine or pelvis and longer metastasis-free interval. In the multivariate analysis, curative-intent surgery for solitary bone metastasis was associated with better survival (HR 0.21; 95 % CI 0.08–0.53; p = 0.001).
Curative-intent surgery for solitary bone metastasis from sarcoma is associated with a better prognosis and is a reasonable treatment strategy whenever feasible.
Synopsis: Curative-intent en-bloc resection of solitary bone metastasis from sarcoma was associated with improved disease-specific survival. The perioperative complication rate following metastasectomy was similar to that for primary bone sarcomas.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Bone Neoplasms - secondary</subject><subject>Bone Neoplasms - surgery</subject><subject>Complication</subject><subject>Disease-specific survival</subject><subject>en-bloc resection</subject><subject>Extremities - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Metastasectomy</subject><subject>Metastasis-free survival</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sarcoma - pathology</subject><subject>Sarcoma - secondary</subject><subject>Sarcoma - surgery</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Soft Tissue Neoplasms - secondary</subject><subject>Soft Tissue Neoplasms - surgery</subject><subject>Survival Rate</subject><subject>Torso</subject><subject>Tumor Burden</subject><subject>Young Adult</subject><issn>0748-7983</issn><issn>1532-2157</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9rFDEUx4Modlv9BzxIjl5mzY_ZZCKClEVroeCl4jG8ZN7YrDOTNclUe-8fbtatPQqBlzw-7xveh5BXnK054-rtbo27HNeCibY2jFTmCVnxjRSN4Bv9lKyYbrtGm06ekNOcd4xVSJvn5ESaTau5FCtyv10SlHCLTZgLzoXmJX3HdEeHmGiOYyhQHy7OSCcskOsJmQ4pThR_l4RTKHcU5p6WtMw_6C8YR5oh-TjBO_rtBgqFhLTcII1LqV3Mf-l624_B15_jnD-8IM8GGDO-fKhn5Ounj9fbz83Vl4vL7flV44XUpTFKtbITTg7ccQUdAxS9G5zSPWgujOoAXC-YU31bNTghPKBSZmiZH0B4eUbeHHP3Kf5cMBc7hexxHGHGuGQruehMx_RGV1QcUZ9izgkHu09hqi4sZ_Zg3-7swb492LdH-3Xo9UP-4ibsH0f-6a7A-yOAdcvbgMlmH3D22IeEvtg-hv_l_wEXB5lw</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Zhang, Liuzhe</creator><creator>Mattei, Jean-Camille</creator><creator>Griffin, Anthony M.</creator><creator>Tsoi, Kim</creator><creator>Ferguson, Peter C.</creator><creator>Wunder, Jay S.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6260-3267</orcidid><orcidid>https://orcid.org/0000-0003-4329-2333</orcidid><orcidid>https://orcid.org/0000-0003-0656-2365</orcidid><orcidid>https://orcid.org/0000-0003-4462-3974</orcidid><orcidid>https://orcid.org/0000-0002-5978-9400</orcidid></search><sort><creationdate>202501</creationdate><title>Curative-intent surgery for solitary bone metastasis from extremity and trunk wall sarcoma: What are the outcomes and complications?</title><author>Zhang, Liuzhe ; Mattei, Jean-Camille ; Griffin, Anthony M. ; Tsoi, Kim ; Ferguson, Peter C. ; Wunder, Jay S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c237t-9664382b3f1b16a80ae2dbfb67da712968aabd20b6d4153b22cae669f40cfa2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Bone Neoplasms - secondary</topic><topic>Bone Neoplasms - surgery</topic><topic>Complication</topic><topic>Disease-specific survival</topic><topic>en-bloc resection</topic><topic>Extremities - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Metastasectomy</topic><topic>Metastasis-free survival</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sarcoma - pathology</topic><topic>Sarcoma - secondary</topic><topic>Sarcoma - surgery</topic><topic>Soft Tissue Neoplasms - pathology</topic><topic>Soft Tissue Neoplasms - secondary</topic><topic>Soft Tissue Neoplasms - surgery</topic><topic>Survival Rate</topic><topic>Torso</topic><topic>Tumor Burden</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Liuzhe</creatorcontrib><creatorcontrib>Mattei, Jean-Camille</creatorcontrib><creatorcontrib>Griffin, Anthony M.</creatorcontrib><creatorcontrib>Tsoi, Kim</creatorcontrib><creatorcontrib>Ferguson, Peter C.</creatorcontrib><creatorcontrib>Wunder, Jay S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Liuzhe</au><au>Mattei, Jean-Camille</au><au>Griffin, Anthony M.</au><au>Tsoi, Kim</au><au>Ferguson, Peter C.</au><au>Wunder, Jay S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curative-intent surgery for solitary bone metastasis from extremity and trunk wall sarcoma: What are the outcomes and complications?</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2025-01</date><risdate>2025</risdate><volume>51</volume><issue>1</issue><spage>109369</spage><pages>109369-</pages><artnum>109369</artnum><issn>0748-7983</issn><issn>1532-2157</issn><eissn>1532-2157</eissn><abstract>Approximately 40–50 % of sarcoma patients will develop lung metastasis, but only 10 % will develop bone metastasis. The survival benefit of surgery for solitary bone metastasis remains unclear.
From 1987 to 2019, 47 patients who underwent curative-intent treatment for localized bone or soft tissue sarcoma in the extremities or trunk wall developed solitary bone metastases as the first distant recurrence. Of them, 51 % (24/47) received curative-intent metastasectomy. We compared the clinicopathologic characteristics of the metastasectomy versus non-metastasectomy patients and evaluated the prognostic impact of solitary bone metastasectomy. The primary outcome measure was disease-specific survival (DSS) after developing solitary bone metastasis.
The post-metastasis DSS was worse with larger primary tumour size (HR 1.09; 95 % CI 1.02–1.16; p = 0.01) and bone metastasis in the pelvis or spine versus other bones (HR 3.79, 95 % CI 1.46–9.87; p = 0.01), and better with curative-intent surgery for the solitary bone metastasis (HR 0.14; 95 % CI 0.06–0.34; p < 0.001). The median DSS was 43 (95 % CI, 24–69) months for the metastasectomy group vs. 13 (95 % CI, 7–19) months for the non-metastasectomy group (p < 0.001). The metastasectomy group had fewer patients with metastasis in the spine or pelvis and longer metastasis-free interval. In the multivariate analysis, curative-intent surgery for solitary bone metastasis was associated with better survival (HR 0.21; 95 % CI 0.08–0.53; p = 0.001).
Curative-intent surgery for solitary bone metastasis from sarcoma is associated with a better prognosis and is a reasonable treatment strategy whenever feasible.
Synopsis: Curative-intent en-bloc resection of solitary bone metastasis from sarcoma was associated with improved disease-specific survival. The perioperative complication rate following metastasectomy was similar to that for primary bone sarcomas.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39547132</pmid><doi>10.1016/j.ejso.2024.109369</doi><orcidid>https://orcid.org/0000-0002-6260-3267</orcidid><orcidid>https://orcid.org/0000-0003-4329-2333</orcidid><orcidid>https://orcid.org/0000-0003-0656-2365</orcidid><orcidid>https://orcid.org/0000-0003-4462-3974</orcidid><orcidid>https://orcid.org/0000-0002-5978-9400</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0748-7983 |
| ispartof | European journal of surgical oncology, 2025-01, Vol.51 (1), p.109369, Article 109369 |
| issn | 0748-7983 1532-2157 1532-2157 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3128980757 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aged Bone Neoplasms - secondary Bone Neoplasms - surgery Complication Disease-specific survival en-bloc resection Extremities - surgery Female Humans Male Metastasectomy Metastasis-free survival Middle Aged Prognosis Retrospective Studies Sarcoma - pathology Sarcoma - secondary Sarcoma - surgery Soft Tissue Neoplasms - pathology Soft Tissue Neoplasms - secondary Soft Tissue Neoplasms - surgery Survival Rate Torso Tumor Burden Young Adult |
| title | Curative-intent surgery for solitary bone metastasis from extremity and trunk wall sarcoma: What are the outcomes and complications? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T10%3A58%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Curative-intent%20surgery%20for%20solitary%20bone%20metastasis%20from%20extremity%20and%20trunk%20wall%20sarcoma:%20What%20are%20the%20outcomes%20and%20complications?&rft.jtitle=European%20journal%20of%20surgical%20oncology&rft.au=Zhang,%20Liuzhe&rft.date=2025-01&rft.volume=51&rft.issue=1&rft.spage=109369&rft.pages=109369-&rft.artnum=109369&rft.issn=0748-7983&rft.eissn=1532-2157&rft_id=info:doi/10.1016/j.ejso.2024.109369&rft_dat=%3Cproquest_cross%3E3128980757%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3128980757&rft_id=info:pmid/39547132&rft_els_id=S0748798324014379&rfr_iscdi=true |